Specific association of human telomerase activity with immortal cells and cancer - Test2 - elhamkhani - TriplyDB

Specific association of human telomerase activity with immortal cells and cancer

Specific association of human telomerase activity with immortal cells and cancer

http://www.wikidata.org/entity/Q27860801

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Short telomeres initiate telomere recombination in primary and tumor cells Preclinical evidences toward the use of triterpenoid CDDO-Me for solid cancer prevention and treatment TIN2, a new regulator of telomere length in human cells Imputation and subset based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33 Mutations in ATP6N1B, encoding a new kidney vacuolar proton pump 116-kD subunit, cause recessive distal renal tubular acidosis with preserved hearing Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation.Human telomerase contains two cooperating telomerase RNA molecules.Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts Suppression of alternative lengthening of telomeres by Sp100-mediated sequestration of the MRE11/RAD50/NBS1 complex.Structural basis of selective ubiquitination of TRF1 by SCFFbx4 Human Ku70/80 interacts directly with hTR, the RNA component of human telomerase Grainyhead-like 2 enhances the human telomerase reverse transcriptase gene expression by inhibiting DNA methylation at the 5'-CpG island in normal human keratinocytes A quantitative telomeric chromatin isolation protocol identifies different telomeric states Telomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongation Characterization and cell cycle regulation of the related human telomeric proteins Pin2 and TRF1 suggest a role in mitosis Modulation of human telomerase reverse transcriptase in hepatocellular carcinoma Regulation of the hTERT promoter activity by MSH2, the hnRNPs K and D, and GRHL2 in human oral squamous cell carcinoma cells PinX1, a telomere repeat-binding factor 1 (TRF1)-interacting protein, maintains telomere integrity by modulating TRF1 homeostasis, the process in which human telomerase reverse Transcriptase (hTERT) plays dual roles POT1 association with TRF2 regulates telomere length Human telomerase and its regulation Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita Minimum length requirement of the alignment domain of human telomerase RNA to sustain catalytic activity in vitro Cell cycle-dependent recruitment of telomerase RNA and Cajal bodies to human telomeres Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1 Mini- and microsatellites Allosteric inhibitors of telomerase: oligonucleotide N3'-->P5' phosphoramidates Identification of two RNA-binding proteins associated with human telomerase RNA Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding Mapping of the gene for the human telomerase reverse transcriptase, hTERT, to chromosome 5p15.33 by fluorescence in situ hybridization Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cells Control of human telomere length by TRF1 and TRF2 Smurf2 up-regulation activates telomere-dependent senescence A biomarker that identifies senescent human cells in culture and in aging skin in vivo Retinoids down-regulate telomerase and telomere length in a pathway distinct from leukemia cell differentiation A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33 Telomere elongation in immortal human cells without detectable telomerase activity Large-scale parent-child comparison confirms a strong paternal influence on telomere length The genetics of dyskeratosis congenita Human telomerase contains evolutionarily conserved catalytic and structural subunits

P2860

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P2860

Specific association of human telomerase activity with immortal cells and cancer

http://www.wikidata.org/entity/Q27860801

description

1994 nî lūn-bûn

@nan

1994 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

1994 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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1994年の論文

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1994年論文

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1994年論文

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1994年論文

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1994年論文

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1994年論文

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1994年论文

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name

Specific association of human telomerase activity with immortal cells and cancer

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Specific association of human telomerase activity with immortal cells and cancer

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Specific association of human telomerase activity with immortal cells and cancer

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type

label

Specific association of human telomerase activity with immortal cells and cancer

@ast

Specific association of human telomerase activity with immortal cells and cancer

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Specific association of human telomerase activity with immortal cells and cancer

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prefLabel

Specific association of human telomerase activity with immortal cells and cancer

@ast

Specific association of human telomerase activity with immortal cells and cancer

@en

Specific association of human telomerase activity with immortal cells and cancer

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Specific association of human telomerase activity with immortal cells and cancer

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C B Harley

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G M Coviello

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J W Shay

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K R Prowse

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M A Piatyszek

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M D West

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N W Kim

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S L Weinrich

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W E Wright

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2011-5

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scholarly article

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231701

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10.1126/SCIENCE.7605428

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266

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