Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery? - Test2 - elhamkhani - TriplyDB

Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery?

Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery?

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A Review on Platensimycin: A Selective FabF Inhibitor The AEROPATH project targetingPseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery Structural Basis for Feed-Forward Transcriptional Regulation of Membrane Lipid Homeostasis in Staphylococcus aureus Discovery of an Allosteric Inhibitor Binding Site in 3-Oxo-acyl-ACP Reductase from Pseudomonas aeruginosa Structural insights into bacterial resistance to cerulenin Resistance Mechanisms and the Future of Bacterial Enoyl-Acyl Carrier Protein Reductase (FabI) Antibiotics FapR: From Control of Membrane Lipid Homeostasis to a Biotechnological Tool Pseudomonas aeruginosa directly shunts β-oxidation degradation intermediates into de novo fatty acid biosynthesis Fatty acid biosynthesis in Pseudomonas aeruginosa is initiated by the FabY class of β-ketoacyl acyl carrier protein synthases Legionella shows a diverse secondary metabolism dependent on a broad spectrum Sfp-type phosphopantetheinyl transferase Dissecting the Structural Elements for the Activation of β-Ketoacyl-(Acyl Carrier Protein) Reductase from Vibrio cholerae.Making life difficult for Clostridium difficile: augmenting the pathogen's metabolic model with transcriptomic and codon usage data for better therapeutic target characterization Biotin analogues with antibacterial activity are potent inhibitors of biotin protein ligase.Genome-wide fitness analyses of the foodborne pathogen Campylobacter jejuni in in vitro and in vivo models.Mechanisms of self-resistance in the platensimycin- and platencin-producing Streptomyces platensis MA7327 and MA7339 strains.Role of lipase from community-associated methicillin-resistant Staphylococcus aureus strain USA300 in hydrolyzing triglycerides into growth-inhibitory free fatty acids.Transcription factors FabR and FadR regulate both aerobic and anaerobic pathways for unsaturated fatty acid biosynthesis in Shewanella oneidensis 4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide (ML267), a potent inhibitor of bacterial phosphopantetheinyl transferase that attenuates secondary metabolism and thwarts bacterial growth.FabH mutations confer resistance to FabF-directed antibiotics in Staphylococcus aureus How bacterial pathogens eat host lipids: implications for the development of fatty acid synthesis therapeutics.Discovery of novel bacterial elongation condensing enzyme inhibitors by virtual screening.A Substrate Mimic Allows High-Throughput Assay of the FabA Protein and Consequently the Identification of a Novel Inhibitor of Pseudomonas aeruginosa FabA Discovery of bacterial fatty acid synthase type II inhibitors using a novel cellular bioluminescent reporter assay.Growth-Environment Dependent Modulation of Staphylococcus aureus Branched-Chain to Straight-Chain Fatty Acid Ratio and Incorporation of Unsaturated Fatty Acids Platensimycin and platencin: Inspirations for chemistry, biology, enzymology, and medicine.Crystallographic insights into the structure-activity relationships of diazaborine enoyl-ACP reductase inhibitors.A Facile Semi-Synthetic Approach towards Halogen-Substituted Aminobenzoic Acid Analogues of Platensimycin.Activation of Exogenous Fatty Acids to Acyl-Acyl Carrier Protein Cannot Bypass FabI Inhibition in Neisseria.Staphylococcus aureus fatty acid auxotrophs do not proliferate in mice Environmental fatty acids enable emergence of infectious Staphylococcus aureus resistant to FASII-targeted antimicrobials.A conditional mutant of the fatty acid synthase unveils unexpected cross talks in mycobacterial lipid metabolism.N-acylated derivatives of sulfamethoxazole block Chlamydia fatty acid synthesis and interact with FabF.Biotin biosynthesis in Mycobacterium tuberculosis: physiology, biochemistry and molecular intervention.Structure, function and selective inhibition of bacterial acetyl-coa carboxylase.Inhibitors of fatty acid synthesis in prokaryotes and eukaryotes as anti-infective, anticancer and anti-obesity drugs.Recent advances in inhibitors of bacterial fatty acid synthesis type II (FASII) system enzymes as potential antibacterial agents.Fatty acid biosynthesis revisited: structure elucidation and metabolic engineering.Mechanistic assessment of DNA ligase as an antibacterial target in Staphylococcus aureus.Antibiotic resistance in Staphylococcus aureus. Current status and future prospects.Evaluation of antibacterial and antibiofilm mechanisms by usnic acid against methicillin-resistant Staphylococcus aureus.

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Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery?

http://www.wikidata.org/entity/Q35350186

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2011 nî lūn-bûn

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2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2011 թվականի օգոստոսին հրատարակված գիտական հոդված

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery?

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Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery?

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Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery?

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Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery?

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Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery?

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Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery?

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J.MIB.2011.07.029

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Current Opinion in Microbiology

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Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery?

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Charles O Rock

http://www.w3.org/2001/XMLSchema#string

Joshua B Parsons

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P2860

Discovery of FabH/FabF inhibitors from natural products.

Mechanism of action of CM-55, a synthetic analogue of the antilipogenic antibiotic cerulenin

Lipid A modification systems in gram-negative bacteria

Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties

Molecular basis of triclosan activity

Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI)

A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore

Mechanism of triclosan inhibition of bacterial fatty acid synthesis

The enoyl-[acyl-carrier-protein] reductases FabI and FabL from Bacillus subtilis

Inhibitors of FabI, an enzyme drug target in the bacterial fatty acid biosynthesis pathway.

P304

544-549

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scholarly article

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10.1016/J.MIB.2011.07.029

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5

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14

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2011-08-20T00:00:00Z

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51591017

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21862391

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3193581

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