Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties - Test2 - elhamkhani - TriplyDB

Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties

Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties

http://www.wikidata.org/entity/Q24674719

about

Platensimycin activity against mycobacterial beta-ketoacyl-ACP synthases Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes A Review on Platensimycin: A Selective FabF Inhibitor Review of Platensimycin and Platencin: Inhibitors of β-Ketoacyl-acyl Carrier Protein (ACP) Synthase III (FabH)Whole-genome sequencing targets drug-resistant bacterial infections Bacterial lipids: metabolism and membrane homeostasis Structure of 3-oxoacyl-(acyl-carrier protein) synthase II fromThermus thermophilusHB8 Structural characterization and comparison of three acyl-carrier-protein synthases from pathogenic bacteria Structural insights into bacterial resistance to cerulenin Antibacterial targets in fatty acid biosynthesis Comparative genome-scale metabolic reconstruction and flux balance analysis of multiple Staphylococcus aureus genomes identify novel antimicrobial drug targets Structural Characterisation of the Beta-Ketoacyl-Acyl Carrier Protein Synthases, FabF and FabH, of Yersinia pestis Targeting the chromosome partitioning protein ParA in tuberculosis drug discovery Downregulation of yidC in Escherichia coli by antisense RNA expression results in sensitization to antibacterial essential oils eugenol and carvacrol Antibiotics May Trigger Mitochondrial Dysfunction Inducing Psychiatric Disorders Bioprospecting microbial natural product libraries from the marine environment for drug discovery.Targeting the fatty acid biosynthesis enzyme, beta-ketoacyl-acyl carrier protein synthase III (PfKASIII), in the identification of novel antimalarial agents.Blueprint for antimicrobial hit discovery targeting metabolic networks Current approaches to exploit actinomycetes as a source of novel natural products.Postgenomic strategies in antibacterial drug discovery.Challenges of antibacterial discovery Engineering of Streptomyces platensis MA7339 for overproduction of platencin and congeners.Systematics-guided bioprospecting for bioactive microbial natural products.Environmental DNA-encoded antibiotics fasamycins A and B inhibit FabF in type II fatty acid biosynthesis A genome-wide inducible phenotypic screen identifies antisense RNA constructs silencing Escherichia coli essential genes Antibiotics and bacterial resistance in the 21st century.Aminobenzoates as building blocks for natural product assembly lines.Exploring anti-TB leads from natural products library originated from marine microbes and medicinal plants.Strain prioritization for natural product discovery by a high-throughput real-time PCR method.Mechanisms of self-resistance in the platensimycin- and platencin-producing Streptomyces platensis MA7327 and MA7339 strains.Expression of the platencin biosynthetic gene cluster in heterologous hosts yielding new platencin congeners.Are natural products still the best source for antibacterial discovery? The bacterial entry factor.Regulated Expression Systems for Mycobacteria and Their Applications From nature to the laboratory and into the clinic Occurrence, distribution, dereplication and efficient discovery of thiazolyl peptides by sensitive-resistant pair screening.Engineered Streptomyces platensis strains that overproduce antibiotics platensimycin and platencin.Conformational diversity of bacterial FabH: implications for molecular recognition specificity.FabH mutations confer resistance to FabF-directed antibiotics in Staphylococcus aureus A detailed study of antibacterial 3-acyltetramic acids and 3-acylpiperidine-2,4-diones.Dedicated ent-kaurene and ent-atiserene synthases for platensimycin and platencin biosynthesis.

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P2860

Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties

http://www.wikidata.org/entity/Q24674719

description

2007 nî lūn-bûn

@nan

2007 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2007 թվականի մայիսին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties

@ast

Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties

@en

Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties

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type

label

Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties

@ast

Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties

@en

Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties

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prefLabel

Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties

@ast

Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties

@en

Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties

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Proceedings of the National Academy of Sciences of the United States of America

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Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties

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Andrew Galgoci

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Angela Basilio

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Doris F Cully

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Elizabeth Tinney

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Fernando Pelaez

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Francisca Vicente

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Fred Racine

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Hiranthi Jayasuriya

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Ignacio González

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Jun Wang

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P2860

THE STRUCTURAL BIOLOGY OF TYPE II FATTY ACID BIOSYNTHESIS

A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae

Discovery of FabH/FabF inhibitors from natural products.

Essential Bacillus subtilis genes

Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism

First X-ray cocrystal structure of a bacterial FabH condensing enzyme and a small molecule inhibitor achieved using rational design and homology modeling

Structural and functional organization of the animal fatty acid synthase

Global transposon mutagenesis and a minimal Mycoplasma genome

inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis

Determination of selectivity and efficacy of fatty acid synthesis inhibitors.

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