Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. - Test2 - elhamkhani - TriplyDB

Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.

Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.

http://www.wikidata.org/entity/Q35486021

about

Metabolism leaves its mark on the powerhouse: recent progress in post-translational modifications of lysine in mitochondria SIRT2 induces the checkpoint kinase BubR1 to increase lifespan Emerging therapeutic roles for NAD(+) metabolism in mitochondrial and age-related disorders Potential Modulation of Sirtuins by Oxidative Stress Review: can diet influence the selective advantage of mitochondrial DNA haplotypes?Age-Associated Weight Gain, Leptin, and SIRT1: A Possible Role for Hypothalamic SIRT1 in the Prevention of Weight Gain and Aging through Modulation of Leptin Sensitivity Sirtuins as regulators of metabolism and healthspan Adipose tissue and adipokines: the association with and application of adipokines in obesity The molecular clock as a metabolic rheostat Adipokines - removing road blocks to obesity and diabetes therapy Sirtuins, metabolism, and DNA repair Undercover: gene control by metabolites and metabolic enzymes SIRT3 in Cardiac Physiology and Disease Sirtuin deacylases: a molecular link between metabolism and immunity Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging Slowing ageing by design: the rise of NAD(+) and sirtuin-activating compounds SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity High-Protein Intake during Weight Loss Therapy Eliminates the Weight-Loss-Induced Improvement in Insulin Action in Obese Postmenopausal Women Isonicotinamide enhances Sir2 protein-mediated silencing and longevity in yeast by raising intracellular NAD+ concentration.Expression and regulation of nampt in human islets.Muscle lipogenesis balances insulin sensitivity and strength through calcium signaling.A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration CD36 deficiency impairs the small intestinal barrier and induces subclinical inflammation in mice.Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK.Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1/AMPKα/SREBP1 signaling pathway Recent progress in metabolic signaling pathways regulating aging and life span Mitochondrial response to nutrient availability and its role in metabolic disease.Nicotinamide mononucleotide attenuates brain injury after intracerebral hemorrhage by activating Nrf2/HO-1 signaling pathway.Nicotinamide ameliorates palmitate-induced ER stress in hepatocytes via cAMP/PKA/CREB pathway-dependent Sirt1 upregulation A method to identify and validate mitochondrial modulators using mammalian cells and the worm C. elegans.Adipose tissue NAD+ biology in obesity and insulin resistance: From mechanism to therapy NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells.Sirtuins: guardians of mammalian healthspan.Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases It takes two to tango: NAD+ and sirtuins in aging/longevity control The ways and means that fine tune Sirt1 activity.The NAD World 2.0: the importance of the inter-tissue communication mediated by NAMPT/NAD+/SIRT1 in mammalian aging and longevity control.Drosophila Sirt2/mammalian SIRT3 deacetylates ATP synthase β and regulates complex V activity.Targeting sirtuins for the treatment of diabetes NAD+ and sirtuins in aging and disease.

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P2860

Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.

http://www.wikidata.org/entity/Q35486021

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2011 nî lūn-bûn

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2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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J.CMET.2011.08.014

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Cell Metabolism

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Nicotinamide mononucleotide, a ...... age-induced diabetes in mice.

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Jun Yoshino

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Kathryn F Mills

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Myeong Jin Yoon

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Shin-ichiro Imai

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P2860

Inflammation and insulin resistance

Epidemiologic and economic consequences of the global epidemics of obesity and diabetes

Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase.

Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme

Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms

PAGE: parametric analysis of gene set enrichment

A nutrient-sensitive interaction between Sirt1 and HNF-1α regulates Crp expression

Mammalian sirtuins: biological insights and disease relevance

Mitochondrial dysfunction and type 2 diabetes

"Clocks" in the NAD World: NAD as a metabolic oscillator for the regulation of metabolism and aging

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