Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo.
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Systematic Classification of Mixed-Lineage Leukemia Fusion Partners Predicts Additional Cancer PathwaysModulation of Protein-Protein Interactions for the Development of Novel TherapeuticsProperty Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL)The molecular mechanics of mixed lineage leukemia.Successful strategies in the discovery of small-molecule epigenetic modulators with anticancer potential.Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyondCCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements.MLL1 is essential for the senescence-associated secretory phenotypeMenin-MLL inhibitors block oncogenic transformation by MLL-fusion proteins in a fusion partner-independent manner.Epigenetics of hematopoiesis and hematological malignancies.Targeting Mll1 H3K4 methyltransferase activity to guide cardiac lineage specific reprogramming of fibroblasts.Kmt2a cooperates with menin to suppress tumorigenesis in mouse pancreatic islets.Tumorigenicity of Ewing sarcoma is critically dependent on the trithorax proteins MLL1 and menin.Diagnosis and Therapy of Acute Myeloid Leukemia in the Era of Molecular Risk Stratification.Drugging Chromatin in Cancer: Recent Advances and Novel Approaches.Inhibitors of protein methyltransferases as chemical tools.The upstreams and downstreams of H3K79 methylation by DOT1L.Reprogramming of histone methylation controls the differentiation of monocytes into macrophages.Inhibitors of Protein Methyltransferases and Demethylases.The emerging role of PI3K/AKT-mediated epigenetic regulation in cancer.SON and Its Alternatively Spliced Isoforms Control MLL Complex-Mediated H3K4me3 and Transcription of Leukemia-Associated Genes.Epigenetic balance of gene expression by Polycomb and COMPASS families.Deregulation of the HOXA9/MEIS1 axis in acute leukemia.Targeting the MLL complex in castration-resistant prostate cancer.Targeting human SET1/MLL family of proteins.DNMT3A in Leukemia.NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis.Recent progress in developing selective inhibitors of protein methyltransferases.PI3K/AKT Signaling Regulates H3K4 Methylation in Breast CancerDevelopment and Use of Assay Conditions Suited to Screening for and Profiling of SET-Domain-Targeted Inhibitors of the MLL/SET1 Family of Lysine Methyltransferases.Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia.MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia.Pharmacologic Targeting of Chromatin Modulators As Therapeutics of Acute Myeloid LeukemiaTrithorax group genes in hematopoiesis.LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis.Targeting multiple nodes of MLL complexes to improve leukemia therapy.Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction.Pharmacologic Inhibition of the Menin-MLL Interaction Leads to Transcriptional Repression of PEG10 and Blocks Hepatocellular Carcinoma.MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy.
P2860
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P2860
Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Pharmacologic inhibition of th ...... ssion of MLL leukemia in vivo.
@ast
Pharmacologic inhibition of th ...... ssion of MLL leukemia in vivo.
@en
type
label
Pharmacologic inhibition of th ...... ssion of MLL leukemia in vivo.
@ast
Pharmacologic inhibition of th ...... ssion of MLL leukemia in vivo.
@en
prefLabel
Pharmacologic inhibition of th ...... ssion of MLL leukemia in vivo.
@ast
Pharmacologic inhibition of th ...... ssion of MLL leukemia in vivo.
@en
P2093
P2860
P1433
P1476
Pharmacologic inhibition of th ...... ssion of MLL leukemia in vivo.
@en
P2093
Andrew G Muntean
Bhavna Malik
Dale L Bixby
Dmitry Borkin
Gwenn Danet-Desnoyers
Hongliang Zong
Hongzhi Miao
Jay L Hess
P2860
P304
P356
10.1016/J.CCELL.2015.02.016
P407
P577
2015-03-26T00:00:00Z