Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming.
about
Boolean modelling reveals new regulatory connections between transcription factors orchestrating the development of the ventral spinal cordGhrelin expression in the mouse pancreas defines a unique multipotent progenitor populationGenome-edited human stem cell-derived beta cells: a powerful tool for drilling down on type 2 diabetes GWAS biologyβ-Cell regeneration through the transdifferentiation of pancreatic cells: Pancreatic progenitor cells in the pancreasHomeodomain proteins: an updatePancreas-specific Cre driver lines and considerations for their prudent useControl of cell identity in pancreas development and regenerationAltered Phenotype of β-Cells and Other Pancreatic Cell Lineages in Patients With Diffuse Congenital Hyperinsulinism in Infancy Caused by Mutations in the ATP-Sensitive K-Channel.Epigenetic Regulation of Islet Development and RegenerationGene network-based analysis identifies two potential subtypes of small intestinal neuroendocrine tumors.Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity.Regulation of Neurod1 contributes to the lineage potential of Neurogenin3+ endocrine precursor cells in the pancreasRepression of Zeb1 and hypoxia cause sequential mesenchymal-to-epithelial transition and induction of aid, Oct4, and Dnmt1, leading to immortalization and multipotential reprogramming of fibroblasts in spheresTransdifferentiation of pancreatic α-cells into insulin-secreting cells: From experimental models to underlying mechanisms.Macrophage/epithelium cross-talk regulates cell cycle progression and migration in pancreatic progenitors.A systems view of epigenetic networks regulating pancreas development and β-cell functionThe transcriptional co-repressor Grg3/Tle3 promotes pancreatic endocrine progenitor delamination and β-cell differentiation.Deconstructing pancreas developmental biology.DNA methylation directs functional maturation of pancreatic β cells.MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function.Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure.Dynamic recruitment of functionally distinct Swi/Snf chromatin remodeling complexes modulates Pdx1 activity in islet β cellsMnx1: a gatekeeper of β cell fate.The novel enterochromaffin marker Lmx1a regulates serotonin biosynthesis in enteroendocrine cell lineages downstream of Nkx2.2.Regulation of the timing of oligodendrocyte differentiation: mechanisms and perspectives.Mouse muscle as an ectopic permissive site for human pancreatic development.Genetic evidence that Nkx2.2 and Pdgfra are major determinants of the timing of oligodendrocyte differentiation in the developing CNS.Pancreatic β cell identity requires continual repression of non-β cell programs.Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage developmentPdx1 maintains β cell identity and function by repressing an α cell program.Grg3/TLE3 and Grg1/TLE1 induce monohormonal pancreatic β-cells while repressing α-cell functions.Epigenetics and diabetes treatment: an unrealized promise?Lineage determinants in early endocrine development.The epigenome and its role in diabetes.Developmental and environmental epigenetic programming of the endocrine pancreas: consequences for type 2 diabetes.Gene regulatory networks governing pancreas development.Epigenetic regulation of pancreatic islets.Notch signaling in the pancreas: patterning and cell fate specification.Transcriptional control of mammalian pancreas organogenesis.Regulation of Pancreatic Beta Cell Stimulus-Secretion Coupling by microRNAs.
P2860
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P2860
Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Nkx2.2 repressor complex regul ...... nts β-to-α-cell reprogramming.
@ast
Nkx2.2 repressor complex regul ...... nts β-to-α-cell reprogramming.
@en
type
label
Nkx2.2 repressor complex regul ...... nts β-to-α-cell reprogramming.
@ast
Nkx2.2 repressor complex regul ...... nts β-to-α-cell reprogramming.
@en
prefLabel
Nkx2.2 repressor complex regul ...... nts β-to-α-cell reprogramming.
@ast
Nkx2.2 repressor complex regul ...... nts β-to-α-cell reprogramming.
@en
P2093
P2860
P356
P1433
P1476
Nkx2.2 repressor complex regul ...... nts β-to-α-cell reprogramming.
@en
P2093
Anil Bhushan
James B Papizan
Jessica M Friel
Lori Sussel
Sangeeta Dhawan
Shuen-Ing Tschen
Susan B Hipkens
P2860
P304
P356
10.1101/GAD.173039.111
P577
2011-11-01T00:00:00Z