Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming. - Test2 - elhamkhani - TriplyDB

Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming.

Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming.

http://www.wikidata.org/entity/Q35559133

about

Boolean modelling reveals new regulatory connections between transcription factors orchestrating the development of the ventral spinal cord Ghrelin expression in the mouse pancreas defines a unique multipotent progenitor population Genome-edited human stem cell-derived beta cells: a powerful tool for drilling down on type 2 diabetes GWAS biology β-Cell regeneration through the transdifferentiation of pancreatic cells: Pancreatic progenitor cells in the pancreas Homeodomain proteins: an update Pancreas-specific Cre driver lines and considerations for their prudent use Control of cell identity in pancreas development and regeneration Altered Phenotype of β-Cells and Other Pancreatic Cell Lineages in Patients With Diffuse Congenital Hyperinsulinism in Infancy Caused by Mutations in the ATP-Sensitive K-Channel.Epigenetic Regulation of Islet Development and Regeneration Gene network-based analysis identifies two potential subtypes of small intestinal neuroendocrine tumors.Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity.Regulation of Neurod1 contributes to the lineage potential of Neurogenin3+ endocrine precursor cells in the pancreas Repression of Zeb1 and hypoxia cause sequential mesenchymal-to-epithelial transition and induction of aid, Oct4, and Dnmt1, leading to immortalization and multipotential reprogramming of fibroblasts in spheres Transdifferentiation of pancreatic α-cells into insulin-secreting cells: From experimental models to underlying mechanisms.Macrophage/epithelium cross-talk regulates cell cycle progression and migration in pancreatic progenitors.A systems view of epigenetic networks regulating pancreas development and β-cell function The transcriptional co-repressor Grg3/Tle3 promotes pancreatic endocrine progenitor delamination and β-cell differentiation.Deconstructing pancreas developmental biology.DNA methylation directs functional maturation of pancreatic β cells.MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function.Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure.Dynamic recruitment of functionally distinct Swi/Snf chromatin remodeling complexes modulates Pdx1 activity in islet β cells Mnx1: a gatekeeper of β cell fate.The novel enterochromaffin marker Lmx1a regulates serotonin biosynthesis in enteroendocrine cell lineages downstream of Nkx2.2.Regulation of the timing of oligodendrocyte differentiation: mechanisms and perspectives.Mouse muscle as an ectopic permissive site for human pancreatic development.Genetic evidence that Nkx2.2 and Pdgfra are major determinants of the timing of oligodendrocyte differentiation in the developing CNS.Pancreatic β cell identity requires continual repression of non-β cell programs.Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage development Pdx1 maintains β cell identity and function by repressing an α cell program.Grg3/TLE3 and Grg1/TLE1 induce monohormonal pancreatic β-cells while repressing α-cell functions.Epigenetics and diabetes treatment: an unrealized promise?Lineage determinants in early endocrine development.The epigenome and its role in diabetes.Developmental and environmental epigenetic programming of the endocrine pancreas: consequences for type 2 diabetes.Gene regulatory networks governing pancreas development.Epigenetic regulation of pancreatic islets.Notch signaling in the pancreas: patterning and cell fate specification.Transcriptional control of mammalian pancreas organogenesis.Regulation of Pancreatic Beta Cell Stimulus-Secretion Coupling by microRNAs.

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Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming.

http://www.wikidata.org/entity/Q35559133

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Nkx2.2 repressor complex regul ...... nts β-to-α-cell reprogramming.

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Nkx2.2 repressor complex regul ...... nts β-to-α-cell reprogramming.

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Anil Bhushan

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James B Papizan

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Jessica M Friel

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Lori Sussel

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Sangeeta Dhawan

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Shuen-Ing Tschen

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Susan B Hipkens

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P2860

Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation

Switching cell fate: the remarkable rise of induced pluripotent stem cells and lineage reprogramming technologies

Building developmental gene regulatory networks

FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site

Generalized lacZ expression with the ROSA26 Cre reporter strain

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

In vivo reprogramming of adult pancreatic exocrine cells to beta-cells

Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells

Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3

The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas

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2291-2305

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21

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22056672

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3219233

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