FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site - Test2 - elhamkhani - TriplyDB

FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site

FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site

http://www.wikidata.org/entity/Q24671057

about

Foxa2 and MafA regulate islet-specific glucose-6-phosphatase catalytic subunit-related protein gene expression MafB is required for islet beta cell maturation A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells Transcription factor regulation of pancreatic organogenesis, differentiation and maturation Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3 Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet Pax6 is crucial for β-cell function, insulin biosynthesis, and glucose-induced insulin secretion Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets.Altered MENIN expression disrupts the MAFA differentiation pathway in insulinoma Transcriptional regulation of the distal promoter of the rat pyruvate carboxylase gene by hepatocyte nuclear factor 3beta/Foxa2 and upstream stimulatory factors in insulinoma cells Nkx2.2 regulates beta-cell function in the mature islet A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis.Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development Nkx2.2 activates the ghrelin promoter in pancreatic islet cells.The nuclear orphan receptor Nur77 is a lipotoxicity sensor regulating glucose-induced insulin secretion in pancreatic β-cells The MafA transcription factor becomes essential to islet β-cells soon after birth.Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells.Novel computational analysis of protein binding array data identifies direct targets of Nkx2.2 in the pancreas.Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain.Mafa expression enhances glucose-responsive insulin secretion in neonatal rat beta cells.In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice.Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming.A small molecule differentiation inducer increases insulin production by pancreatic β cells Research resource: the pdx1 cistrome of pancreatic islets.Insm1 cooperates with Neurod1 and Foxa2 to maintain mature pancreatic β-cell function Glucose induces MafA expression in pancreatic beta cell lines via the hexosamine biosynthetic pathway.Tshz1 Regulates Pancreatic β-Cell Maturation.Hnf1α (MODY3) regulates β-cell-enriched MafA transcription factor expression.SSBP3 Interacts With Islet-1 and Ldb1 to Impact Pancreatic β-Cell Target Genes.Mnx1: a gatekeeper of β cell fate.Characterization of an apparently novel β-cell line-enriched 80-88 kDa transcriptional activator of the MafA and Pdx1 genes Islet α-, β-, and δ-cell development is controlled by the Ldb1 coregulator, acting primarily with the islet-1 transcription factor.βlinc1 encodes a long noncoding RNA that regulates islet β-cell formation and function Glucolipotoxicity: fuel excess and beta-cell dysfunction.Inactivation of specific β cell transcription factors in type 2 diabetes.The novel enterochromaffin marker Lmx1a regulates serotonin biosynthesis in enteroendocrine cell lineages downstream of Nkx2.2.On the origin of the beta cell.Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas.LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells.

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P2860

FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site

http://www.wikidata.org/entity/Q24671057

description

2006 nî lūn-bûn

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2006 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2006 թվականի օգոստոսին հրատարակված գիտական հոդված

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2006年の論文

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FoxA2, Nkx2.2, and PDX-1 regul ...... m the transcription start site

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FoxA2, Nkx2.2, and PDX-1 regul ...... m the transcription start site

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FoxA2, Nkx2.2, and PDX-1 regul ...... m the transcription start site

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FoxA2, Nkx2.2, and PDX-1 regul ...... m the transcription start site

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FoxA2, Nkx2.2, and PDX-1 regul ...... m the transcription start site

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FoxA2, Nkx2.2, and PDX-1 regul ...... m the transcription start site

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FoxA2, Nkx2.2, and PDX-1 regul ...... m the transcription start site

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FoxA2, Nkx2.2, and PDX-1 regul ...... m the transcription start site

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FoxA2, Nkx2.2, and PDX-1 regul ...... m the transcription start site

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Molecular and Cellular Biology

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FoxA2, Nkx2.2, and PDX-1 regul ...... m the transcription start site

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Christopher B Newgard

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Eva Henderson

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Isabella Artner

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Jeffrey C Raum

http://www.w3.org/2001/XMLSchema#string

Kevin Gerrish

http://www.w3.org/2001/XMLSchema#string

Min Guo

http://www.w3.org/2001/XMLSchema#string

Roland Stein

http://www.w3.org/2001/XMLSchema#string

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Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus

PAX6 mutation as a genetic factor common to aniridia and glucose intolerance

MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene

Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice

Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA.

Conserved sequences in a tissue-specific regulatory region of the pdx-1 gene mediate transcription in Pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6

Expanding the TRANSFAC database towards an expert system of regulatory molecular mechanisms

Control of pancreas and liver gene expression by HNF transcription factors

The MafA transcription factor appears to be responsible for tissue-specific expression of insulin

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5735-43

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scholarly article

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2392904

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10.1128/MCB.00249-06

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15

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26

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2006-08-01T00:00:00Z

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