Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci - Test2 - elhamkhani - TriplyDB

Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci

Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci

http://www.wikidata.org/entity/Q35575687

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Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants.Research Resource: A Reference Transcriptome for Constitutive Androstane Receptor and Pregnane X Receptor Xenobiotic Signaling Solving the Conundrum: Immunogenetics of Sarcoidosis IκBζ is a key driver in the development of psoriasis.A Review of Recent Advancement in Integrating Omics Data with Literature Mining towards Biomedical Discoveries.Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.Throat Infections are Associated with Exacerbation in a Substantial Proportion of Patients with Chronic Plaque Psoriasis IκBζ: an emerging player in cancer.Imiquimod has strain-dependent effects in mice and does not uniquely model human psoriasis.CARMA2sh and ULK2 control pathogen-associated molecular patterns recognition in human keratinocytes: psoriasis-linked CARMA2sh mutants escape ULK2 censorship.Strategies for fine-mapping complex traits.Novel systemic therapies for the treatment of psoriasis.The role of IL-23 and the IL-23/TH 17 immune axis in the pathogenesis and treatment of psoriasis.Psoriasis-Associated Late Cornified Envelope (LCE) Proteins Have Antibacterial Activity.miR-146b Probably Assists miRNA-146a in the Suppression of Keratinocyte Proliferation and Inflammatory Responses in Psoriasis.Tofacitinib for the treatment of psoriasis.Association of IL12B risk haplotype and lack of interaction with HLA-Cw6 among the psoriasis patients in India.HLA-Cw6 homozygosity in plaque psoriasis is associated with streptococcal throat infections and pronounced improvement after tonsillectomy: A prospective case series.IL-17A plays a central role in the expression of psoriasis signature genes through the induction of IκB-ζ in keratinocytes.Integrative analyses reveal biological pathways and key genes in psoriasis.Genotype combination contributes to psoriasis: An exhaustive algorithm perspective.The Act1 D10N missense variant impairs CD40 signaling in human B-cells.Exome-wide association study reveals novel psoriasis susceptibility locus at TNFSF15 and rare protective alleles in genes contributing to type I IFN signalling.Scanning the Immunopathogenesis of Psoriasis.TNF blockade induces a dysregulated type I interferon response without autoimmunity in paradoxical psoriasis.IL-17 Responses Are the Dominant Inflammatory Signal Linking Inverse, Erythrodermic, and Chronic Plaque Psoriasis.IL-17F regulates psoriasis-associated genes through IκBζ.CARD14 mutations may predict response to antitumour necrosis factor-α therapy in psoriasis: a potential further step towards personalized medicine.Research Techniques Made Simple: Using Genome-Wide Association Studies to Understand Complex Cutaneous Disorders.Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis.The Genetic Basis of Psoriasis.Human Leukocyte Antigen-Class I Alleles and the Autoreactive T Cell Response in Psoriasis Pathogenesis.A catalog of potential putative functional variants in psoriasis genome-wide association regions.Cross-genetic determination of maternal and neonatal immune mediators during pregnancy Genetic signature to provide robust risk assessment of psoriatic arthritis development in psoriasis patients

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P2860

Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci

http://www.wikidata.org/entity/Q35575687

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Enhanced meta-analysis and rep ...... psoriasis susceptibility loci

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Andre Franke

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Charlotta Enerback

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Cheryl F Rosen

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Gerald G Krueger

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Goncalo R Abecasis

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Hyun M Kang

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James T Elder

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Johann E Gudjonsson

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John J Voorhees

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Jonathan N W N Barker

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An integrated encyclopedia of DNA elements in the human genome

An integrated map of genetic variation from 1,092 human genomes

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

The NHGRI GWAS Catalog, a curated resource of SNP-trait associations

GENCODE: the reference human genome annotation for The ENCODE Project

The emerging role of IL-17 in the pathogenesis of psoriasis: preclinical and clinical findings

Association analyses identify six new psoriasis susceptibility loci in the Chinese population

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways

Immunology of psoriasis

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10.1038/NCOMMS8001

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6

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Richard C Trembath

Dafna D. Gladman

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Sylviane Lambert

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2015-05-05T00:00:00Z

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25939698

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susceptibility locus

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