The MDM2 RING domain and central acidic domain play distinct roles in MDM2 protein homodimerization and MDM2-MDMX protein heterodimerization.
about
Clinical Overview of MDM2/X-Targeted TherapiesMDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer.MDM2 oligomers: antagonizers of the guardian of the genome.Characterization of cancer-associated missense mutations in MDM2.Numb contributes to renal fibrosis by promoting tubular epithelial cell cycle arrest at G2/MPleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53.Ubiquitin-specific peptidase 48 regulates Mdm2 protein levels independent of its deubiquitinase activity.The fate of murine double minute X (MdmX) is dictated by distinct signaling pathways through murine double minute 2 (Mdm2).E3 ubiquitin ligases in cancer and implications for therapies.Alterations in expression levels of genes in p53-related pathways determined using RNA-Seq analysis in patients with breast cancer following CIK therapy.Inactivation of the MDM2 RING domain enhances p53 transcriptional activity in mice.p53 promotes its own polyubiquitination by enhancing the HDM2 and HDMX interaction.
P2860
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P2860
The MDM2 RING domain and central acidic domain play distinct roles in MDM2 protein homodimerization and MDM2-MDMX protein heterodimerization.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
The MDM2 RING domain and centr ...... MX protein heterodimerization.
@ast
The MDM2 RING domain and centr ...... MX protein heterodimerization.
@en
type
label
The MDM2 RING domain and centr ...... MX protein heterodimerization.
@ast
The MDM2 RING domain and centr ...... MX protein heterodimerization.
@en
prefLabel
The MDM2 RING domain and centr ...... MX protein heterodimerization.
@ast
The MDM2 RING domain and centr ...... MX protein heterodimerization.
@en
P2860
P356
P1476
The MDM2 RING domain and centr ...... MX protein heterodimerization.
@en
P2093
Patrick L Leslie
Yanping Zhang
P2860
P304
12941-12950
P356
10.1074/JBC.M115.644435
P407
P50
P577
2015-03-25T00:00:00Z