An essential function of the extreme C-terminus of MDM2 can be provided by MDMX
about
Turning the RING domain protein MdmX into an active ubiquitin-protein ligaseRegulation of p53 stability and function by the deubiquitinating enzyme USP42Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligaseMdmX is a substrate for the deubiquitinating enzyme USP2aMutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stabilityAberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2RING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitinationRINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesisDeubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in transStructures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitmentRING domain dimerization is essential for RNF4 functionBIRC7–E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimerEssentiality of a non-RING element in priming donor ubiquitin for catalysis by a monomeric E3Regulation of ubiquitin transfer by XIAP, a dimeric RING E3 ligaseBMI1-RING1B is an autoinhibited RING E3 ubiquitin ligaseRegulation of p53 by Mdm2 E3 ligase function is dispensable in embryogenesis and development, but essential in response to DNA damageMDM2 and MDMX: Alone and together in regulation of p53Modes of p53 regulationChanges in PUB22 Ubiquitination Modes Triggered by MITOGEN-ACTIVATED PROTEIN KINASE3 Dampen the Immune Response.MDM4 (MDMX) and its Transcript Variants.PIG3 Regulates p53 Stability by Suppressing Its MDM2-Mediated UbiquitinationmicroRNAs and Alu elements in the p53-Mdm2-Mdm4 regulatory network.Suppression of p53 activity by Siva1MDM2 oligomers: antagonizers of the guardian of the genome.The anaphase-promoting complex/cyclosome is an E3 ubiquitin ligase for Mdm2.Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2.The p53 orchestra: Mdm2 and Mdmx set the toneMDM2, MDMX and p53 in oncogenesis and cancer therapyRibosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesisPhosphatases in the cellular response to DNA damage.Validation of MdmX as a therapeutic target for reactivating p53 in tumorsNanosensing protein allostery using a bivalent mouse double minute two (MDM2) assayLimiting the power of p53 through the ubiquitin proteasome pathway.Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice.Deconstructing nucleotide binding activity of the Mdm2 RING domain.OTUD5 regulates p53 stability by deubiquitinating p53.Making sense of ubiquitin ligases that regulate p53.Structural and functional comparison of the RING domains of two p53 E3 ligases, Mdm2 and Pirh2.A small-molecule p53 activator induces apoptosis through inhibiting MDMX expression in breast cancer cells.
P2860
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P2860
An essential function of the extreme C-terminus of MDM2 can be provided by MDMX
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
An essential function of the extreme C-terminus of MDM2 can be provided by MDMX
@ast
An essential function of the extreme C-terminus of MDM2 can be provided by MDMX
@en
An essential function of the extreme C-terminus of MDM2 can be provided by MDMX
@en-gb
An essential function of the extreme C-terminus of MDM2 can be provided by MDMX
@nl
type
label
An essential function of the extreme C-terminus of MDM2 can be provided by MDMX
@ast
An essential function of the extreme C-terminus of MDM2 can be provided by MDMX
@en
An essential function of the extreme C-terminus of MDM2 can be provided by MDMX
@en-gb
An essential function of the extreme C-terminus of MDM2 can be provided by MDMX
@nl
prefLabel
An essential function of the extreme C-terminus of MDM2 can be provided by MDMX
@ast
An essential function of the extreme C-terminus of MDM2 can be provided by MDMX
@en
An essential function of the extreme C-terminus of MDM2 can be provided by MDMX
@en-gb
An essential function of the extreme C-terminus of MDM2 can be provided by MDMX
@nl
P2093
P2860
P356
P1433
P1476
An essential function of the extreme C-terminus of MDM2 can be provided by MDMX
@en
P2093
Karen H Vousden
Stjepan Uldrijan
Willem-Jan Pannekoek
P2860
P304
P356
10.1038/SJ.EMBOJ.7601469
P407
P577
2007-01-10T00:00:00Z