7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease.
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7,8-Dihydroxyflavone, a small molecule TrkB agonist, improves spatial memory and increases thin spine density in a mouse model of Alzheimer disease-like neuronal lossPost-injury treatment with 7,8-dihydroxyflavone, a TrkB receptor agonist, protects against experimental traumatic brain injury via PI3K/Akt signaling7,8-dihydroxyflavone, a small molecular TrkB agonist, is useful for treating various BDNF-implicated human disordersNovel small molecule activators of the Trk family of receptor tyrosine kinasesMolecular Pathways Bridging Frontotemporal Lobar Degeneration and Psychiatric DisordersPotential therapeutic effects of neurotrophins for acute and chronic neurological diseasesThe flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model miceFlavonoid derivative 7,8-DHF attenuates TBI pathology via TrkB activation.Intake of 7,8-Dihydroxyflavone During Juvenile and Adolescent Stages Prevents Onset of Psychosis in Adult Offspring After Maternal Immune ActivationDisruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice.Protection of spiral ganglion neurons from degeneration using small-molecule TrkB receptor agonists.7,8,3'-Trihydroxyflavone, a potent small molecule TrkB receptor agonist, protects spiral ganglion neurons from degeneration both in vitro and in vivoComputational identification of potential multitarget treatments for ameliorating the adverse effects of amyloid-β on synaptic plasticityPERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease.Epigenetic enhancement of brain-derived neurotrophic factor signaling pathway improves cognitive impairments induced by isoflurane exposure in aged ratsBiochemical and biophysical investigation of the brain-derived neurotrophic factor mimetic 7,8-dihydroxyflavone in the binding and activation of the TrkB receptor.Optimization of a small tropomyosin-related kinase B (TrkB) agonist 7,8-dihydroxyflavone active in mouse models of depression.Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease7,8-Dihydroxyflavone, a TrkB agonist, attenuates behavioral abnormalities and neurotoxicity in mice after administration of methamphetamine.Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease.7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease.Small-molecule trkB agonists promote axon regeneration in cut peripheral nerves7,8-dihydroxyflavone, a small-molecule tropomyosin-related kinase B (TrkB) agonist, attenuates cerebral ischemia and reperfusion injury in rats.7,8-Dihydroxyflavone improves motor performance and enhances lower motor neuronal survival in a mouse model of amyotrophic lateral sclerosis.A peptide binding to the β-site of APP improves spatial memory and attenuates Aβ burden in Alzheimer's disease transgenic miceNew insight in expression, transport, and secretion of brain-derived neurotrophic factor: Implications in brain-related diseases.Deletion of the eIF2α Kinase GCN2 fails to rescue the memory decline associated with Alzheimer's disease.IGF2 ameliorates amyloidosis, increases cholinergic marker expression and raises BMP9 and neurotrophin levels in the hippocampus of the APPswePS1dE9 Alzheimer's disease model mice.Is Dysregulation of the HPA-Axis a Core Pathophysiology Mediating Co-Morbid Depression in Neurodegenerative Diseases?Beneficial effects of the β-secretase inhibitor GRL-8234 in 5XFAD Alzheimer's transgenic mice lessen during disease progression.TrkB reduction exacerbates Alzheimer's disease-like signaling aberrations and memory deficits without affecting β-amyloidosis in 5XFAD mice.Fear extinction and BDNF: translating animal models of PTSD to the clinic.SCM-198 Ameliorates Cognitive Deficits, Promotes Neuronal Survival and Enhances CREB/BDNF/TrkB Signaling without Affecting Aβ Burden in AβPP/PS1 Mice.Intraperitoneal Administration of a Novel TAT-BDNF Peptide Ameliorates Cognitive Impairments via Modulating Multiple Pathways in Two Alzheimer's Rodent Models.Norepinephrine Protects against Amyloid-β Toxicity via TrkB.ERα Signaling Is Required for TrkB-Mediated Hippocampal Neuroprotection in Female Neonatal Mice after Hypoxic Ischemic Encephalopathy(1,2,3).Activity-dependent, stress-responsive BDNF signaling and the quest for optimal brain health and resilience throughout the lifespanProbing the ability of presynaptic tyrosine kinase receptors to regulate striatal dopamine dynamics.Development of amyloid burden in African Green monkeys.Individual differences in novelty seeking predict subsequent vulnerability to social defeat through a differential epigenetic regulation of brain-derived neurotrophic factor expression.
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P2860
7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
7,8-dihydroxyflavone, a small- ...... model of Alzheimer's disease.
@ast
7,8-dihydroxyflavone, a small- ...... model of Alzheimer's disease.
@en
type
label
7,8-dihydroxyflavone, a small- ...... model of Alzheimer's disease.
@ast
7,8-dihydroxyflavone, a small- ...... model of Alzheimer's disease.
@en
prefLabel
7,8-dihydroxyflavone, a small- ...... model of Alzheimer's disease.
@ast
7,8-dihydroxyflavone, a small- ...... model of Alzheimer's disease.
@en
P2860
P356
P1476
7,8-dihydroxyflavone, a small- ...... model of Alzheimer's disease.
@en
P2093
Latha Devi
Masuo Ohno
P2860
P2888
P304
P356
10.1038/NPP.2011.191
P407
P577
2011-09-07T00:00:00Z