In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation
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Monoubiquitylation promotes mitochondrial p53 translocationHLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53Mutually exclusive subsets of BH3-only proteins are activated by the p53 and c-Jun N-terminal kinase/c-Jun signaling pathways during cortical neuron apoptosis induced by arsenitep53 acetylation is crucial for its transcription-independent proapoptotic functionsAlterations in Mitochondrial and Endoplasmic Reticulum Signaling by p53 MutantsKnow the enemy as well as the weapons in hand: the aberrant death pathways and therapeutic agents in chronic lymphocytic leukemiap53 and mitochondrial dysfunction: novel insight of neurodegenerative diseasesDeletion of genes implicated in protecting the integrity of male germ cells has differential effects on the incidence of DNA breaks and germ cell lossStochasticity of intranuclear biochemical reaction processes controls the final decision of cell fate associated with DNA damageThe p53 tumor suppressor is stabilized by inhibitor of growth 1 (ING1) by blocking polyubiquitinationLACE1 interacts with p53 and mediates its mitochondrial translocation and apoptosis9-Aminoacridine inhibition of HIV-1 Tat dependent transcription.Effects of small interfering RNA inhibit Class I phosphoinositide 3-kinase on human gastric cancer cells.Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis.Irradiation-induced translocation of p53 to mitochondria in the absence of apoptosis.Modeling the role of p53 pulses in DNA damage- induced cell death decision.Inhibition of Mitochondrial p53 Accumulation by PFT-μ Prevents Cisplatin-Induced Peripheral Neuropathy.High Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia.Translocation of p53 to mitochondria is regulated by its lipid binding property to anionic phospholipids and it participates in cell death control.Orphan receptor TR3 enhances p53 transactivation and represses DNA double-strand break repair in hepatoma cells under ionizing radiation.SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localizationEngineering a leucine zipper-TRAIL homotrimer with improved cytotoxicity in tumor cellsp53's mitochondrial translocation and MOMP action is independent of Puma and Bax and severely disrupts mitochondrial membrane integrityNDRG2 promotes adriamycin sensitivity through a Bad/p53 complex at the mitochondria in breast cancer.Mutant p53 exhibits trivial effects on mitochondrial functions which can be reactivated by ellipticine in lymphoma cells.Modulation of p53, c-fos, RARE, cyclin A, and cyclin D1 expression in human leukemia (HL-60) cells exposed to arsenic trioxideA dual-targeting, p53-independent, apoptosis-inducing platinum(II) anticancer complex, [Pt(BDI(QQ))]Cl.Identification of a structural motif in the tumor-suppressive protein GRIM-19 required for its antitumor activityTargeting wild-type and mutant p53 with small molecule CP-31398 blocks the growth of rhabdomyosarcoma by inducing reactive oxygen species-dependent apoptosis.Effects of estrogen metabolite 2-methoxyestradiol on tumor suppressor protein p53 and proliferation of breast cancer cells.Systemic lupus erythematosus and increased risk to develop B cell malignancies: role of the p200-family proteins.Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol gammaGRAMD4 mimics p53 and mediates the apoptotic function of p73 at mitochondria.The novel tryptamine derivative JNJ-26854165 induces wild-type p53- and E2F1-mediated apoptosis in acute myeloid and lymphoid leukemias.In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute.A two-step mechanism for cell fate decision by coordination of nuclear and mitochondrial p53 activities.SIRT1 and p53, effect on cancer, senescence and beyond.Ubiquitin and ubiquitin-like proteins in the nucleolus: multitasking tools for a ribosome factory.Disparate chromatin landscapes and kinetics of inactivation impact differential regulation of p53 target genesRegulation of transactivation-independent proapoptotic activity of p53 by FOXO3a
P2860
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P2860
In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
In vivo mitochondrial p53 tran ...... ede p53 target gene activation
@ast
In vivo mitochondrial p53 tran ...... ede p53 target gene activation
@en
type
label
In vivo mitochondrial p53 tran ...... ede p53 target gene activation
@ast
In vivo mitochondrial p53 tran ...... ede p53 target gene activation
@en
prefLabel
In vivo mitochondrial p53 tran ...... ede p53 target gene activation
@ast
In vivo mitochondrial p53 tran ...... ede p53 target gene activation
@en
P2093
P2860
P1476
In vivo mitochondrial p53 tran ...... ede p53 target gene activation
@en
P2093
Motohiro Mihara
Oleksi Petrenko
Roger H Kim
Susan Erster
Ute M Moll
P2860
P304
P356
10.1128/MCB.24.15.6728-6741.2004
P407
P577
2004-08-01T00:00:00Z