In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute. - Test2 - elhamkhani - TriplyDB

In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute.

In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute.

http://www.wikidata.org/entity/Q34280884

about

PUMA, a potent killer with or without p53 Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy Caspase-2 activation in the absence of PIDDosome formation Apoptosis, autophagy and unfolded protein response pathways in Arbovirus replication and pathogenesis Tumor suppressor p53 and its gain-of-function mutants in cancer Tumor suppressor p53 and its mutants in cancer metabolism Small molecule compounds targeting the p53 pathway: are we finally making progress?Hypoxia-induced modulation of apoptosis and BCL-2 family proteins in different cancer cell types Estrogen-mediated upregulation of Noxa is associated with cell cycle progression in estrogen receptor-positive breast cancer cells Role of p63 and the Notch pathway in cochlea development and sensorineural deafness Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim.Growth of the developing cerebral cortex is controlled by microRNA-7 through the p53 pathway.BH3-only proteins in apoptosis and beyond: an overview.Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim Analysis of BH3-only proteins upregulated in response to oxygen/glucose deprivation in cortical neurons identifies Bmf but not Noxa as potential mediator of neuronal injury.Synergistic induction of cell death in liver tumor cells by TRAIL and chemotherapeutic drugs via the BH3-only proteins Bim and Bid New insights into p53 activation The essential role of evasion from cell death in cancer.Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53 The p53-PUMA axis suppresses iPSC generation Dihydroartemisinin induces apoptosis preferentially via a Bim-mediated intrinsic pathway in hepatocarcinoma cells.Fas death receptor signalling: roles of Bid and XIAP.Inhibition of AMP-activated protein kinase α (AMPKα) by doxorubicin accentuates genotoxic stress and cell death in mouse embryonic fibroblasts and cardiomyocytes: role of p53 and SIRT1.The Epstein-Barr Virus BART miRNA Cluster of the M81 Strain Modulates Multiple Functions in Primary B Cells.BH3-only proteins in apoptosis at a glance The DNA damage checkpoint protein ATM promotes hepatocellular apoptosis and fibrosis in a mouse model of non-alcoholic fatty liver disease.The BCL-2 protein family, BH3-mimetics and cancer therapy.Cycloheximide Can Induce Bax/Bak Dependent Myeloid Cell Death Independently of Multiple BH3-Only Proteins Deubiquitinase USP9x confers radioresistance through stabilization of Mcl-1 DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa Repression of p53-target gene Bbc3/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance.Metabolic regulation by p53 family members.The p53 family and programmed cell death The proapoptotic BH3-only, Bcl-2 family member, Puma is critical for acute ethanol-induced neuronal apoptosis.Bcl2 family proteins in carcinogenesis and the treatment of cancer.Caspase-cleaved arrestin-2 and BID cooperatively facilitate cytochrome C release and cell death.Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasis Evaluation of the BH3-only protein Puma as a direct Bak activator JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis.

P2860

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P2860

In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute.

http://www.wikidata.org/entity/Q34280884

description

2008 nî lūn-bûn

@nan

2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2008年の論文

@ja

2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

name

In several cell types tumour s ...... Puma but Noxa can contribute.

@ast

In several cell types tumour s ...... Puma but Noxa can contribute.

@en

In several cell types tumour s ...... Puma but Noxa can contribute.

@nl

type

label

In several cell types tumour s ...... Puma but Noxa can contribute.

@ast

In several cell types tumour s ...... Puma but Noxa can contribute.

@en

In several cell types tumour s ...... Puma but Noxa can contribute.

@nl

prefLabel

In several cell types tumour s ...... Puma but Noxa can contribute.

@ast

In several cell types tumour s ...... Puma but Noxa can contribute.

@en

In several cell types tumour s ...... Puma but Noxa can contribute.

@nl

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P2860

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P1433

Cell Death & Differentiation

P1476

In several cell types tumour s ...... Puma but Noxa can contribute.

@en

P2093

A Villunger

http://www.w3.org/2001/XMLSchema#string

E M Michalak

http://www.w3.org/2001/XMLSchema#string

J M Adams

http://www.w3.org/2001/XMLSchema#string

P2860

PUMA induces the rapid apoptosis of colorectal cancer cells

PUMA, a novel proapoptotic gene, is induced by p53

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

p53 has a direct apoptogenic role at the mitochondria

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells

PUMA couples the nuclear and cytoplasmic proapoptotic function of p53

Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

Suppression of tumorigenesis by the p53 target PUMA

P2888

P304

1019-1029

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scholarly article

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10.1038/CDD.2008.16

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P433

6

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P478

15

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Andreas Strasser

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2008-02-08T00:00:00Z

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5593412

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1027420302

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18259198

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2974267

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