Large expansion of CTG•CAG repeats is exacerbated by MutSβ in human cells.
about
Myotonic dystrophy type 1 patient-derived iPSCs for the investigation of CTG repeat instability.Contracting CAG/CTG repeats using the CRISPR-Cas9 nickase.Crosstalk between MSH2-MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair.Break-induced replication links microsatellite expansion to complex genome rearrangements.The Top1 paradox: Friend and foe of the eukaryotic genome.Close encounters: Moving along bumps, breaks, and bubbles on expanded trinucleotide tracts.The role of break-induced replication in large-scale expansions of (CAG)n/(CTG)n repeats.MutSβ abundance and Msh3 ATP hydrolysis activity are important drivers of CTG•CAG repeat expansions.RNA-DNA hybrids promote the expansion of Friedreich's ataxia (GAA)n repeats via break-induced replication.The central role of DNA damage and repair in CAG repeat diseases.
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P2860
Large expansion of CTG•CAG repeats is exacerbated by MutSβ in human cells.
description
2015 nî lūn-bûn
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2015年の論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
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2015年论文
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name
Large expansion of CTG•CAG repeats is exacerbated by MutSβ in human cells.
@ast
Large expansion of CTG•CAG repeats is exacerbated by MutSβ in human cells.
@en
type
label
Large expansion of CTG•CAG repeats is exacerbated by MutSβ in human cells.
@ast
Large expansion of CTG•CAG repeats is exacerbated by MutSβ in human cells.
@en
prefLabel
Large expansion of CTG•CAG repeats is exacerbated by MutSβ in human cells.
@ast
Large expansion of CTG•CAG repeats is exacerbated by MutSβ in human cells.
@en
P2093
P2860
P356
P1433
P1476
Large expansion of CTG•CAG repeats is exacerbated by MutSβ in human cells
@en
P2093
Harutoshi Fujimura
Hideki Mochizuki
Masanori P Takahashi
Rie Nakatani
P2860
P2888
P356
10.1038/SREP11020
P407
P50
P577
2015-06-05T00:00:00Z