R loops stimulate genetic instability of CTG.CAG repeats. - Test2 - elhamkhani - TriplyDB

R loops stimulate genetic instability of CTG.CAG repeats.

R loops stimulate genetic instability of CTG.CAG repeats.

http://www.wikidata.org/entity/Q33639972

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Out of balance: R-loops in human disease New insights into repeat instability: role of RNA•DNA hybrids DNA slip-outs cause RNA polymerase II arrest in vitro: potential implications for genetic instability Replication and transcription on a collision course: eukaryotic regulation mechanisms and implications for DNA stability Sources of DNA double-strand breaks and models of recombinational DNA repair The 26S proteasome drives trinucleotide repeat expansions GFP-based fluorescence assay for CAG repeat instability in cultured human cells DNA secondary structure at chromosomal fragile sites in human disease.Processing of double-R-loops in (CAG)·(CTG) and C9orf72 (GGGGCC)·(GGCCCC) repeats causes instability.Convergent transcription through a long CAG tract destabilizes repeats and induces apoptosis Friedreich's ataxia (GAA)n•(TTC)n repeats strongly stimulate mitotic crossovers in Saccharomyces cerevisae.Coherent somatic mutation in autoimmune disease.A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expression DNA dynamics is likely to be a factor in the genomic nucleotide repeats expansions related to diseases.Topoisomerase 1 and single-strand break repair modulate transcription-induced CAG repeat contraction in human cells.Xpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1.Correlation of inter-locus polyglutamine toxicity with CAG•CTG triplet repeat expandability and flanking genomic DNA GC content Complementary roles for exonuclease 1 and Flap endonuclease 1 in maintenance of triplet repeats Hsp90 modulates CAG repeat instability in human cells.Nucleotide excision repair, mismatch repair, and R-loops modulate convergent transcription-induced cell death and repeat instability Bidirectional transcription stimulates expansion and contraction of expanded (CTG)*(CAG) repeats.Transcription elongation and tissue-specific somatic CAG instability.Anchoring nascent RNA to the DNA template could interfere with transcription Determinants of R-loop formation at convergent bidirectionally transcribed trinucleotide repeats Functional consequences of the RNase H2A subunit mutations that cause Aicardi-Goutieres syndrome.DNA topoisomerases participate in fragility of the oncogene RET.G4 motifs correlate with promoter-proximal transcriptional pausing in human genes.R-loops associated with triplet repeat expansions promote gene silencing in Friedreich ataxia and fragile X syndrome.On the sequence-directed nature of human gene mutation: the role of genomic architecture and the local DNA sequence environment in mediating gene mutations underlying human inherited disease.Splicing function of mitotic regulators links R-loop-mediated DNA damage to tumor cell killing Stabilization of expanded (CTG)•(CAG) repeats by antisense oligonucleotides.Quantitative model of R-loop forming structures reveals a novel level of RNA-DNA interactome complexity.Repeat-mediated epigenetic dysregulation of the FMR1 gene in the fragile X-related disorders.Repeat instability during DNA repair: Insights from model systems Large expansion of CTG•CAG repeats is exacerbated by MutSβ in human cells.Topological Behavior of Plasmid DNA Instability of (CTG)n•(CAG)n trinucleotide repeats and DNA synthesis Evolution and function of CAG/polyglutamine repeats in protein-protein interaction networks.Friedreich's ataxia--a case of aberrant transcription termination?Emerging role of RNA•DNA hybrids in C9orf72-linked neurodegeneration.

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P2860

R loops stimulate genetic instability of CTG.CAG repeats.

http://www.wikidata.org/entity/Q33639972

description

2009 nî lūn-bûn

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2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

R loops stimulate genetic instability of CTG.CAG repeats.

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R loops stimulate genetic instability of CTG.CAG repeats.

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type

label

R loops stimulate genetic instability of CTG.CAG repeats.

@ast

R loops stimulate genetic instability of CTG.CAG repeats.

@en

prefLabel

R loops stimulate genetic instability of CTG.CAG repeats.

@ast

R loops stimulate genetic instability of CTG.CAG repeats.

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PNAS.0909740107

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Proceedings of the National Academy of Sciences of the United States of America

P1476

R loops stimulate genetic instability of CTG.CAG repeats.

@en

P2093

John H Wilson

http://www.w3.org/2001/XMLSchema#string

Marek Napierala

http://www.w3.org/2001/XMLSchema#string

Robert D Wells

http://www.w3.org/2001/XMLSchema#string

Sharon Y R Dent

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Yunfu Lin

http://www.w3.org/2001/XMLSchema#string

P2860

The Sequence of the Human Genome

Transcription promotes contraction of CAG repeat tracts in human cells

Contributions of the two accessory subunits, RNASEH2B and RNASEH2C, to the activity and properties of the human RNase H2 complex

Advances in mechanisms of genetic instability related to hereditary neurological diseases.

Mrc1, Tof1 and Csm3 inhibit CAG.CTG repeat instability by at least two mechanisms.

Isolation and characterization of a second RNase H (RNase HII) of Escherichia coli K-12 encoded by the rnhB gene

Guanine is indispensable for immunoglobulin switch region RNA-DNA hybrid formation.

Diverse effects of individual mismatch repair components on transcription-induced CAG repeat instability in human cells.

Progressive GAA.TTC repeat expansion in human cell lines.

Transcription through a simple DNA repeat blocks replication elongation

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692-697

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2

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20080737

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2818888

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