Mitochondrial DNA damage is a hallmark of chemically induced and the R6/2 transgenic model of Huntington's disease - Test2 - elhamkhani - TriplyDB

Mitochondrial DNA damage is a hallmark of chemically induced and the R6/2 transgenic model of Huntington's disease

Mitochondrial DNA damage is a hallmark of chemically induced and the R6/2 transgenic model of Huntington's disease

http://www.wikidata.org/entity/Q35706627

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PGC-1α, mitochondrial dysfunction, and Huntington's disease Mitochondrial DNA damage induced autophagy, cell death, and disease Role of oxidative DNA damage in mitochondrial dysfunction and Huntington's disease pathogenesis Inhibition of mitochondrial protein import by mutant huntingtin Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease Increased mitochondrial fission and neuronal dysfunction in Huntington's disease: implications for molecular inhibitors of excessive mitochondrial fission Mitochondria as a therapeutic target for aging and neurodegenerative diseases.Latrepirdine, a potential novel treatment for Alzheimer's disease and Huntington's chorea.Oxidative genome damage and its repair: implications in aging and neurodegenerative diseases.Age-related instability in spermatogenic cell nuclear and mitochondrial DNA obtained from Apex1 heterozygous mice.Mitochondrial dynamics in cancer and neurodegenerative and neuroinflammatory diseases.Generating Rho-0 Cells Using Mesenchymal Stem Cell Lines.Dysregulation of mitochondrial calcium signaling and superoxide flashes cause mitochondrial genomic DNA damage in Huntington disease.DNA damage in normally and prematurely aged mice.Glutathione-deficient Plasmodium berghei parasites exhibit growth delay and nuclear DNA damage.Aging increases mitochondrial DNA damage and oxidative stress in liver of rhesus monkeys Mitochondrial DNA damage is associated with reduced mitochondrial bioenergetics in Huntington's disease.Mitochondrial structural and functional dynamics in Huntington's disease.Mitochondria: a therapeutic target in neurodegeneration Early dysfunction and progressive degeneration of the subthalamic nucleus in mouse models of Huntington's disease Abnormal mitochondrial dynamics and neurodegenerative diseases.Oxidative Stress and Huntington's Disease: The Good, The Bad, and The Ugly.Abnormal mitochondrial dynamics--a novel therapeutic target for Alzheimer's disease?Tert-buthylhydroquinone pre-conditioning exerts dual effects in old female rats exposed to 3-nitropropionic acid.The interrelationship between mitochondrial dysfunction and transcriptional dysregulation in Huntington disease.Oxidative genome damage and its repair in neurodegenerative diseases: function of transition metals as a double-edged sword.Antioxidants in Huntington's disease.Mitochondrial and metabolic-based protective strategies in Huntington's disease: the case of creatine and coenzyme Q.A mitochondrial basis for Huntington's disease: therapeutic prospects.DNA repair abnormalities leading to ataxia: shared neurological phenotypes and risk factors.The role of glia in stress: polyamines and brain disorders Cognitive interventions to enhance neural compensation in Huntington's disease.AMPK-mediated regulation of neuronal metabolism and function in brain diseases.Quinazoline-based tricyclic compounds that regulate programmed cell death, induce neuronal differentiation, and are curative in animal models for excitotoxicity and hereditary brain disease A novel mitochondrial tRNA(Ala) gene variant causes chronic progressive external ophthalmoplegia in a patient with Huntington disease.Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells.Analysis of DNA damage and repair in nuclear and mitochondrial DNA of animal cells using quantitative PCR.A role for sequestosome 1/p62 in mitochondrial dynamics, import and genome integrity.

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Mitochondrial DNA damage is a hallmark of chemically induced and the R6/2 transgenic model of Huntington's disease

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Carlos A Torres-Ramos

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Karina Acevedo-Torres

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Lexsy Berríos

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Nydia Rosario

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Serguei Skatchkov

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P2860

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

Oxidative stress and neuronal DNA fragmentation mediate age-dependent vulnerability to the mitochondrial toxin, 3-nitropropionic acid, in the mouse striatum.

Efficient repair of abasic sites in DNA by mitochondrial enzymes.

3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme

Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin

Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease

OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells

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1

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23399571

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18935984

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Huntington disease

mitochondrial DNA

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3268004

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