Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation.
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The Role of Amyloid-β Oligomers in Toxicity, Propagation, and ImmunotherapyThe role of macropinocytosis in the propagation of protein aggregation associated with neurodegenerative diseasesThe preclinical phase of the pathological process underlying sporadic Alzheimer's diseasePropagation of tau pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.Roles of tau protein in health and disease.Perivascular AQP4 dysregulation in the hippocampal CA1 area after traumatic brain injury is alleviated by adenosine A2A receptor inactivation.Distinct Therapeutic Mechanisms of Tau Antibodies: Promoting Microglial Clearance Versus Blocking Neuronal Uptake.Short Fibrils Constitute the Major Species of Seed-Competent Tau in the Brains of Mice Transgenic for Human P301S Tau.Vulnerability of newly synthesized proteins to proteostasis stress.Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner.Neuronal activity enhances tau propagation and tau pathology in vivo.Epigenetic dysregulation of brainstem nuclei in the pathogenesis of Alzheimer's disease: looking in the correct place at the right time?Tau Oligomers: Cytotoxicity, Propagation, and Mitochondrial Damage.Prions and Protein Assemblies that Convey Biological Information in Health and Disease.Glucose directs amyloid-beta into membrane-active oligomers.Prion-like propagation as a pathogenic principle in frontotemporal dementia.Potential Pathways of Abnormal Tau and α-Synuclein Dissemination in Sporadic Alzheimer's and Parkinson's Diseases.Cellular Models for the Study of Prions.The Prion-Like Behavior of Assembled Tau in Transgenic Mice.A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies.Formation, release, and internalization of stable tau oligomers in cells.The Distance between N and C Termini of Tau and of FTDP-17 Mutants Is Modulated by Microtubule Interactions in Living Cells.Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients.LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent.Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies.The Neurotoxic TAU45-230 Fragment Accumulates in Upper and Lower Motor Neurons in Amyotrophic Lateral Sclerosis Subjects.Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory.Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes.Amyloid-β and tau complexity - towards improved biomarkers and targeted therapies.Soluble Tau has devastating effects on the structural plasticity of hippocampal granule neurons.Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo.What is the evidence that tau pathology spreads through prion-like propagation?Tau-mediated Neurodegeneration and Potential Implications in Diagnosis and Treatment of Alzheimer's Disease.Widespread tau seeding activity at early Braak stages.Reduced gliotransmitter release from astrocytes mediates tau-induced synaptic dysfunction in cultured hippocampal neurons.Structure-based inhibitors of tau aggregation.FRET and Flow Cytometry Assays to Measure Proteopathic Seeding Activity in Biological Samples.A role for tau in learning, memory and synaptic plasticity.MR-guided delivery of AAV2-BDNF into the entorhinal cortex of non-human primates.Tau Spreading Mechanisms; Implications for Dysfunctional Tauopathies.
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P2860
Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Tau Trimers Are the Minimal Pr ...... eed Intracellular Aggregation.
@ast
Tau Trimers Are the Minimal Pr ...... eed Intracellular Aggregation.
@en
type
label
Tau Trimers Are the Minimal Pr ...... eed Intracellular Aggregation.
@ast
Tau Trimers Are the Minimal Pr ...... eed Intracellular Aggregation.
@en
prefLabel
Tau Trimers Are the Minimal Pr ...... eed Intracellular Aggregation.
@ast
Tau Trimers Are the Minimal Pr ...... eed Intracellular Aggregation.
@en
P2093
P2860
P356
P1476
Tau Trimers Are the Minimal Pr ...... Seed Intracellular Aggregation
@en
P2093
Hilda Mirbaha
Jan Bieschke
Marc I Diamond
P2860
P304
14893-14903
P356
10.1074/JBC.M115.652693
P407
P577
2015-04-17T00:00:00Z