MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition. - Test2 - elhamkhani - TriplyDB

MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition.

MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition.

http://www.wikidata.org/entity/Q35781547

about

Targeting CDK4 and CDK6: From Discovery to Therapy CDK4/6 Inhibitors in Cancer Therapy: A Novel Treatement Strategy for Bladder Cancer.Palbociclib (PD-0332991), a selective CDK4/6 inhibitor, restricts tumour growth in preclinical models of hepatocellular carcinoma.PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma.Oral nano-delivery of anticancer ginsenoside 25-OCH3-PPD, a natural inhibitor of the MDM2 oncogene: Nanoparticle preparation, characterization, in vitro and in vivo anti-prostate cancer activity, and mechanisms of action.Efficacy of CDK4 inhibition against sarcomas depends on their levels of CDK4 and p16ink4 mRNA.Progression-Free Survival Among Patients With Well-Differentiated or Dedifferentiated Liposarcoma Treated With CDK4 Inhibitor Palbociclib: A Phase 2 Clinical Trial.Cell cycle proteins as promising targets in cancer therapy Liposarcoma: Multimodality Management and Future Targeted Therapies.PKCι depletion initiates mitotic slippage-induced senescence in glioblastoma Stromal Senescence By Prolonged CDK4/6 Inhibition Potentiates Tumor Growth.The Strange Case of CDK4/6 Inhibitors: Mechanisms, Resistance, and Combination Strategies.Combined Inhibition of CDK4/6 and PI3K/AKT/mTOR Pathways Induces a Synergistic Anti-Tumor Effect in Malignant Pleural Mesothelioma Cells.ATRX is a regulator of therapy induced senescence in human cells.Induction of Therapeutic Senescence in Vemurafenib-Resistant Melanoma by Extended Inhibition of CDK4/6 CDK4/6 inhibitor: from quiescence to senescence.Clinical and Molecular Spectrum of Liposarcoma.Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas.Drug-resistance in doxorubicin-resistant FL5.12 hematopoietic cells: elevated MDR1, drug efflux and side-population positive and decreased BCL2-family member expression.Mechanistic understanding of the role of ATRX in senescence provides new insight for combinatorial therapies with CDK4 inhibitors.Cell-Cycle Therapeutics Come of Age.Thermal proteome profiling of breast cancer cells reveals proteasomal activation by CDK4/6 inhibitor palbociclib.Alternative lengthening of telomeres phenotype and loss of ATRX expression in sarcomas.CDK4/6 Inhibitors: The Mechanism of Action May Not Be as Simple as Once Thought Palbociclib resistance confers dependence on an FGFR-MAP kinase-mTOR-driven pathway in -mutant non-small cell lung cancer

P2860

Q28082912-74E18792-E928-46AA-AE18-F4F943BB3076 Q33614544-1B4E85E0-FA60-4323-9246-17037384295E Q33907588-D25E86C0-5C42-44E7-862C-45C83FD5B2F8 Q36224716-7172D26F-A14D-47F3-8648-B14BD8C0B104 Q36356343-CD701802-D87D-4A2B-BCB6-8CE7A201A249 Q36562082-5EE174FB-D037-457D-9E15-C8F42A98EF5E Q37189243-B7B7F1F4-ED21-4727-9959-E13500B7E47B Q37693690-25C59024-9E6B-47C2-A250-E1F36FD0D950 Q38824691-CCC9965D-66C4-4963-B161-745DEE20C89C Q38981503-69DED71D-3911-4554-8D25-5A43F55061F0 Q39048659-F610D463-8317-4B61-A2E3-C27625339A7F Q39183079-6E2E1D83-AB9E-4F67-9308-FE3F00F72F7F Q41002619-5C679387-2FFA-4500-AFE5-3B369F652266 Q41565938-01503850-6772-43CD-998A-B1BCDDE6FEAA Q42775668-934FA5A4-E34F-420C-85D8-481A61A989E7 Q43135029-5FA04EC2-1AC3-4466-827C-A4004ECB82E5 Q47315579-BB953326-E0A7-4636-A76B-EC223CC45B66 Q47444902-89BC4421-C048-44F1-8A27-F8E3264C10E8 Q49882954-99BF70B3-4BAC-410D-B746-1210EB26A831 Q50195464-74A5C95B-A0EE-4A05-A27B-EA697E976A49 Q50959563-B136401C-80A3-4A89-9428-A28915F00B36 Q52718493-25DDB6F1-2197-4D0C-9C13-2C337B03D912 Q54985797-B89BD52D-58A2-4E4A-BE62-60341AA589A3 Q57176702-33BA4438-3F18-4A49-87C9-63F77BB9A5AB Q58801080-E0A1FE6B-6412-43B6-8855-A2F571F6FFB0

P2860

MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition.

http://www.wikidata.org/entity/Q35781547

description

2015 nî lūn-bûn

@nan

2015年の論文

@ja

2015年論文

@yue

2015年論文

@zh-hant

2015年論文

@zh-hk

2015年論文

@zh-mo

2015年論文

@zh-tw

2015年论文

@wuu

2015年论文

@zh

2015年论文

@zh-cn

name

MDM2 turnover and expression o ...... n response to CDK4 inhibition.

@ast

MDM2 turnover and expression o ...... n response to CDK4 inhibition.

@en

type

label

MDM2 turnover and expression o ...... n response to CDK4 inhibition.

@ast

MDM2 turnover and expression o ...... n response to CDK4 inhibition.

@en

prefLabel

MDM2 turnover and expression o ...... n response to CDK4 inhibition.

@ast

MDM2 turnover and expression o ...... n response to CDK4 inhibition.

@en

P1433

Q35781547-1541E1DE-8800-413B-939B-751CC6F8BB1D

P1476

Q35781547-F711299E-B32F-488C-A485-234FC5FD814F

P2093

Q35781547-430DB3D4-70D5-4556-BBF8-08034D0F5411

Q35781547-496BCA6C-52EB-43E4-82C0-AAD186871900

Q35781547-88A52A6D-970B-4C22-A9E8-EAA2C6953758

Q35781547-9F2FA6D2-0084-4CB8-8DF3-0DAB7931E51D

Q35781547-C26932D7-9FB1-43E3-AD42-BA362CD8CE3E

Q35781547-CB11C631-CB30-4D7A-B877-95A474C2C4AC

Q35781547-CCA038ED-2AA8-49DD-8202-8978F6C2FDB9

Q35781547-F3E72AA4-363E-494B-B795-1C11C2BE2ABE

P2860

Q35781547-00257F09-1FC3-4DB5-80C7-6D2C98432406

Q35781547-024F9B6D-A2A1-40BD-AE90-5C772DB7D526

Q35781547-02B176FA-046D-4119-9A53-E1BD8C86D3AB

Q35781547-0AB7F4CA-7690-4763-97D0-FE9352D52EF9

Q35781547-0D7BCC16-1FC4-4ADC-B205-5B879039EB76

Q35781547-0E4DBBE9-4DBF-4AE4-839D-4954411762B8

Q35781547-0ECBDC75-7B16-4F2A-B1E2-B2EB426E01B7

Q35781547-0F12748A-F044-4F48-9DBC-51C115E4C4D5

Q35781547-0F308C48-1EDD-4392-998C-E1532AA75191

Q35781547-12211B03-741E-405F-8AEC-B1DB14905FB8

P304

Q35781547-0F62E283-4A71-42F9-B93D-08CCB02AF39D

P31

Q35781547-03424324-1421-4D7F-A42F-6134CCC0C2B9

P356

Q35781547-7F47C291-E6E7-44C2-AB31-0F2D103E4962

P407

Q35781547-DC619697-2C4E-408E-AE56-FE1EFE030ACB

P433

Q35781547-56CDFFAD-CACA-487E-8C03-5745C776C1C7

P478

Q35781547-06DD1A5E-1CEB-4E2B-BFD4-30CAF9235140

P50

Q35781547-8F66A0B8-ADD2-4AF7-8FED-A7169D90E226

Q35781547-9E2D8159-4612-49CD-900F-27F1867F6592

Q35781547-A80837A0-B8E9-4125-8A7D-E467534251A1

Q35781547-B859180E-81DA-480F-B746-74586A2521DA

P577

Q35781547-574E6E81-6B38-4DDC-BD4D-B96D0C6E5F20

P5875

Q35781547-397DEF49-4CBA-49AD-B06B-D2BC5C0E9E23

P698

Q35781547-A25A4EF7-6ECD-42B4-AFE4-9544C6FA63D4

P932

Q35781547-A13470CD-CBE5-4D41-B733-04B0DACEF437

P356

ONCOTARGET.3364

P1433

P1476

MDM2 turnover and expression o ...... in response to CDK4 inhibition

@en

P2093

David D Liu

http://www.w3.org/2001/XMLSchema#string

Fatima O Wilder

http://www.w3.org/2001/XMLSchema#string

Gary K Schwartz

http://www.w3.org/2001/XMLSchema#string

Mark A Dickson

http://www.w3.org/2001/XMLSchema#string

Mary E Klein

http://www.w3.org/2001/XMLSchema#string

Nicholas D Socci

http://www.w3.org/2001/XMLSchema#string

Samuel Singer

http://www.w3.org/2001/XMLSchema#string

William D Tap

http://www.w3.org/2001/XMLSchema#string

P2860

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres

Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase

The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop

A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells

Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase

ATRX-mediated chromatin association of histone variant macroH2A1 regulates α-globin expression

The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

Cellular senescence and tumor suppressor gene p16

P304

8226-8243

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.18632/ONCOTARGET.3364

http://www.w3.org/2001/XMLSchema#string

P407

P433

10

http://www.w3.org/2001/XMLSchema#string

P478

6

http://www.w3.org/2001/XMLSchema#string

P50

Rachael O'Connor

Marta Kovatcheva

P577

2015-04-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

274087566

http://www.w3.org/2001/XMLSchema#string

P698

25803170

http://www.w3.org/2001/XMLSchema#string

P932

4480747

http://www.w3.org/2001/XMLSchema#string