Application of the Hard and Soft, Acids and Bases (HSAB) theory to toxicant--target interactions. - Test2 - elhamkhani - TriplyDB

Application of the Hard and Soft, Acids and Bases (HSAB) theory to toxicant--target interactions.

Application of the Hard and Soft, Acids and Bases (HSAB) theory to toxicant--target interactions.

http://www.wikidata.org/entity/Q35783273

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Pyridoxylamine reactivity kinetics as an amine based nucleophile for screening electrophilic dermal sensitizers Molecular mechanism of acrylamide neurotoxicity: lessons learned from organic chemistry Protein modifications by electrophilic lipoxidation products: adduct formation, chemical strategies and tandem mass spectrometry for their detection and identification The cysteine proteome Reactions of electrophiles with nucleophilic thiolate sites: relevance to pathophysiological mechanisms and remediation Phloroglucinol protects retinal pigment epithelium and photoreceptor against all-trans-retinal-induced toxicity and inhibits A2E formation Characterization of 4-HNE modified L-FABP reveals alterations in structural and functional dynamics.Molecular mechanisms of aldehyde toxicity: a chemical perspective.Acrylamide exposure impairs blood-cerebrospinal fluid barrier function Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): an overview of their mechanisms of formation.Toxic neuropathies: Mechanistic insights based on a chemical perspective A novel class of mitochondria-targeted soft electrophiles modifies mitochondrial proteins and inhibits mitochondrial metabolism in breast cancer cells through redox mechanisms.2-Acetylcyclopentanone, an enolate-forming 1,3-dicarbonyl compound, is cytoprotective in warm ischemia-reperfusion injury of rat liver.Cell signalling by reactive lipid species: new concepts and molecular mechanisms.An overview of the chemistry and biology of reactive aldehydes.Inactivation of CYP2A6 by the Dietary Phenylpropanoid trans-Cinnamic Aldehyde (Cinnamaldehyde) and Estimation of Interactions with Nicotine and Letrozole.Enolate-Forming Phloretin Pharmacophores: Hepatoprotection in an Experimental Model of Drug-Induced Toxicity.Protein targets of acrylamide adduct formation in cultured rat dopaminergic cells.Protective properties of 2-acetylcyclopentanone in a mouse model of acetaminophen hepatotoxicity.Joint toxic effects of the type-2 alkene electrophiles.Lipid mediators involved in the oxidative stress and antioxidant defence of human lung cancer cells.Detection of electrophile-sensitive proteins.Drug discovery for a new generation of covalent drugs.Molecular strategies to prevent, inhibit, and degrade advanced glycoxidation and advanced lipoxidation end products.Detecting reactive drug metabolites for reducing the potential for drug toxicity.Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs.The sphingosine 1-phosphate breakdown product, (2E)-hexadecenal, forms protein adducts and glutathione conjugates in vitro.Protein alkylation by the α,β-unsaturated aldehyde acrolein. A reversible mechanism of electrophile signaling?Bifunctional electrophiles cross-link thioredoxins with redox relay partners in cells.Energy of the Lowest Unoccupied Molecular Orbital, Thiol Reactivity, and Toxicity of Three Monobrominated Water Disinfection Byproducts.Transcriptomics analysis and hormonal changes of male and female neonatal rats treated chronically with a low dose of acrylamide in their drinking water.Model system for irreversible inhibition of Nek2: thiol addition to ethynylpurines and related substituted heterocycles.DFT studies of imino and thiocarbonyl ligands with the pentaaqua Mg²⁺ cation: affinity and associated parameters.Proteomic Analysis of Thiol Modifications and Assessment of Structural Changes in Hemoglobin Induced by the Aniline Metabolites N-Phenylhydroxylamine and Nitrosobenzene.Exploring the oxidative stress response mechanism triggered by environmental water samples.Metal-based proteasomal deubiquitinase inhibitors as potential anticancer agents.Refinement of a Methodology for Untargeted Detection of Serum Albumin Adducts in Human Populations.CONTINUOUS INFUSION OF PHENELZINE, CYCLOSPORINE A OR THE COMBINATION: EVALUATION OF MITOCHONDRIAL BIOENERGETICS, OXIDATIVE DAMAGE AND CYTOSKELETAL DEGRADATION FOLLOWING SEVERE CONTROLLED CORTICAL IMPACT TRAUMATIC BRAIN INJURY IN RATS.Molecular Recognition of Azelaic Acid and Related Molecules with DNA Polymerase I Investigated by Molecular Modeling Calculations.Understanding the cytotoxicity or cytoprotective effects of biological and synthetic quinone derivatives by redox mechanism.

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P2860

Application of the Hard and Soft, Acids and Bases (HSAB) theory to toxicant--target interactions.

http://www.wikidata.org/entity/Q35783273

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2011 nî lūn-bûn

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2011年の論文

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2011年论文

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Application of the Hard and So ...... toxicant--target interactions.

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Application of the Hard and So ...... toxicant--target interactions.

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Application of the Hard and So ...... toxicant--target interactions.

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Application of the Hard and So ...... toxicant--target interactions.

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Application of the Hard and So ...... toxicant--target interactions.

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Application of the Hard and So ...... toxicant--target interactions.

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Chemical Research in Toxicology

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Application of the Hard and So ...... toxicant--target interactions.

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Anthony Decaprio

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David S Barber

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Richard M Lopachin

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Terrence Gavin

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P2860

Twinning in crystals of human skeletal muscle D-glyceraldehyde-3-phosphate dehydrogenase

Inactivation of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal. Selective modification of an active-site lysine

Protein modification by acrolein: formation and stability of cysteine adducts

Mass spectroscopic characterization of protein modification by 4-hydroxy-2-(E)-nonenal and 4-oxo-2-(E)-nonenal.

Protein adduct formation as a molecular mechanism in neurotoxicity.

Covalent modification of amino acid nucleophiles by the lipid peroxidation products 4-hydroxy-2-nonenal and 4-oxo-2-nonenal.

Molecular basis of enzyme inactivation by an endogenous electrophile 4-hydroxy-2-nonenal: identification of modification sites in glyceraldehyde-3-phosphate dehydrogenase.

Covalent adduction of nucleophilic amino acids by 4-hydroxynonenal and 4-oxononenal.

Proteomic analysis of acrylamide-protein adduct formation in rat brain synaptosomes.

TPA-induced up-regulation of activator protein-1 can be inhibited or enhanced by analogs of the natural product curcumin.

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239-251

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10.1021/TX2003257

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2

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25

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22053936

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3288258

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