Resistance to HSV-1 infection in the epithelium resides with the novel innate sensor, IFI-16 - Test2 - elhamkhani - TriplyDB

Resistance to HSV-1 infection in the epithelium resides with the novel innate sensor, IFI-16

Resistance to HSV-1 infection in the epithelium resides with the novel innate sensor, IFI-16

http://www.wikidata.org/entity/Q35783804

about

Intrinsic host restriction factors of human cytomegalovirus replication and mechanisms of viral escape The role of dendritic cells in immunity against primary herpes simplex virus infections Recognition of cytosolic DNA by cGAS and other STING-dependent sensors Immunological aspects of acute and recurrent herpes simplex keratitis The inflammasome as a target of modulation by DNA viruses Herpes Simplex Virus and Interferon Signaling Induce Novel Autophagic Clusters in Sensory Neurons Microglia-induced IL-6 protects against neuronal loss following HSV-1 infection of neural progenitor cells.Interferon γ-inducible protein (IFI) 16 transcriptionally regulates type i interferons and other interferon-stimulated genes and controls the interferon response to both DNA and RNA viruses Herpes keratitis.Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein A STING-dependent innate-sensing pathway mediates resistance to corneal HSV-1 infection via upregulation of the antiviral effector tetherin A Highly Efficacious Herpes Simplex Virus 1 Vaccine Blocks Viral Pathogenesis and Prevents Corneal Immunopathology via Humoral Immunity Interleukin-1α released from HSV-1-infected keratinocytes acts as a functional alarmin in the skin.Degeneration and regeneration of corneal nerves in response to HSV-1 infection Evasion of early antiviral responses by herpes simplex viruses.Nuclear sensing of viral DNA, epigenetic regulation of herpes simplex virus infection, and innate immunity The Current State of Vaccine Development for Ocular HSV-1 Infection Granulocytes in Ocular HSV-1 Infection: Opposing Roles of Mast Cells and Neutrophils Distinct Upstream Role of Type I IFN Signaling in Hematopoietic Stem Cell-Derived and Epithelial Resident Cells for Concerted Recruitment of Ly-6Chi Monocytes and NK Cells via CCL2-CCL3 Cascade Role of the DNA Sensor STING in Protection from Lethal Infection following Corneal and Intracerebral Challenge with Herpes Simplex Virus 1.IFN-α-driven CCL2 production recruits inflammatory monocytes to infection site in mice.The molecular mechanism of breast cancer cell apoptosis induction by absent in melanoma (AIM2)Targeting the genital tract mucosa with a lipopeptide/recombinant adenovirus prime/boost vaccine induces potent and long-lasting CD8+ T cell immunity against herpes: importance of MyD88.Microglia and a functional type I IFN pathway are required to counter HSV-1-driven brain lateral ventricle enlargement and encephalitis Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.Synergistic control of herpes simplex virus pathogenesis by IRF-3, and IRF-7 revealed through non-invasive bioluminescence imaging.Immunological control of herpes simplex virus infections.HSV-1 targets lymphatic vessels in the eye and draining lymph node of mice leading to edema in the absence of a functional type I interferon response.Generating protective immunity against genital herpes Recognition of herpes simplex viruses: toll-like receptors and beyond IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes.Type I interferons in regulation of mucosal immunity.DNA recognition in immunity and disease.Molecular basis of DNA recognition in the immune system.Type I interferon and lymphangiogenesis in the HSV-1 infected cornea - are they beneficial to the host?Cellular sensing of viral DNA and viral evasion mechanisms.Animal models of herpes simplex virus immunity and pathogenesis.Evasion of the STING DNA-Sensing Pathway by VP11/12 of Herpes Simplex Virus 1.Impaired STING Pathway in Human Osteosarcoma U2OS Cells Contributes to the Growth of ICP0-Null Mutant Herpes Simplex Virus.Impact of Type I Interferon on the Safety and Immunogenicity of an Experimental Live-Attenuated Herpes Simplex Virus 1 Vaccine in Mice.

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P2860

Resistance to HSV-1 infection in the epithelium resides with the novel innate sensor, IFI-16

http://www.wikidata.org/entity/Q35783804

description

2012 nî lūn-bûn

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name

Resistance to HSV-1 infection ...... he novel innate sensor, IFI-16

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Resistance to HSV-1 infection ...... he novel innate sensor, IFI-16

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type

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Resistance to HSV-1 infection ...... he novel innate sensor, IFI-16

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Resistance to HSV-1 infection ...... he novel innate sensor, IFI-16

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Resistance to HSV-1 infection ...... he novel innate sensor, IFI-16

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Resistance to HSV-1 infection ...... he novel innate sensor, IFI-16

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Mucosal Immunology

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Resistance to HSV-1 infection ...... he novel innate sensor, IFI-16

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C D Conrady

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D J J Carr

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K A Fitzgerald

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M Zheng

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P2860

IFI16 is an innate immune sensor for intracellular DNA

Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence

RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

The interferon-inducible nucleolar p204 protein binds the ribosomal RNA-specific UBF1 transcription factor and inhibits ribosomal RNA transcription

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

Toll-like receptors

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

Herpes simplex virus encephalitis in human UNC-93B deficiency

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173-183

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10.1038/MI.2011.63

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2

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5

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221740240

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22236996

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3288395

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