Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase. - Test2 - elhamkhani - TriplyDB

Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase.

Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase.

http://www.wikidata.org/entity/Q35811888

about

Inadequate fine-tuning of protein synthesis and failure of amino acid homeostasis following inhibition of the ATPase VCP/p97 Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2α-mediated stress signaling Molecular Insights into the Fungus-Specific Serine/Threonine Protein Phosphatase Z1 in Candida albicans Mouse Rif1 is a regulatory subunit of protein phosphatase 1 (PP1).Profiling the MAPK/ERK dependent and independent activity regulated transcriptional programs in the murine hippocampus in vivo.PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz.α-Asarone blocks 7β-hydroxycholesterol-exposed macrophage injury through blocking elF2α phosphorylation and prompting beclin-1-dependent autophagy GADD34 Function in Protein Trafficking Promotes Adaptation to Hyperosmotic Stress in Human Corneal Cells.Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration.eIF2α phosphorylation is pathognomonic for immunogenic cell death.Oxidative stress promotes SIRT1 recruitment to the GADD34/PP1α complex to activate its deacetylase function.Role of the unfolded protein response in determining the fate of tumor cells and the promise of multi-targeted therapies.Decoding the selectivity of eIF2α holophosphatases and PPP1R15A inhibitors.A Sephin1-insensitive tripartite holophosphatase dephosphorylates translation initiation factor 2α.ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells

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Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase.

http://www.wikidata.org/entity/Q35811888

description

2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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2015年论文

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2015年论文

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Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase.

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Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase.

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Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase.

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Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase.

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Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase.

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Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase.

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J.CELREP.2015.05.043

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Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase.

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Catherine W Goh

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Irene C Lee

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Jocelyn C Newton

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Permeen Yusoff

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Rebecca Page

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Shirish Shenolikar

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Wolfgang Peti

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Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites

Crystal Structures of Protein Phosphatase-1 Bound to Nodularin-R and Tautomycin: A Novel Scaffold for Structure-based Drug Design of Serine/Threonine Phosphatase Inhibitors

The Molecular Basis for Substrate Specificity of the Nuclear NIPP1:PP1 Holoenzyme

Understanding the antagonism of retinoblastoma protein dephosphorylation by PNUTS provides insights into the PP1 regulatory code

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress

Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions

Regulated translation initiation controls stress-induced gene expression in mammalian cells

Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha

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1885-1891

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