Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase.
about
Novel insight into the mechanism of the vitamin K oxidoreductase (VKOR): electron relay through Cys43 and Cys51 reduces VKOR to allow vitamin K reduction and facilitation of vitamin K-dependent protein carboxylationCytochrome P450-dependent catabolism of vitamin K: ω-hydroxylation catalyzed by human CYP4F2 and CYP4F11Structural and functional insights into enzymes of the vitamin K cycleVKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapyLiver-specific γ-glutamyl carboxylase-deficient mice display bleeding diathesis and short life span.The vitamin K-dependent carboxylase generates γ-carboxylated glutamates by using CO2 to facilitate glutamate deprotonation in a concerted mechanism that drives catalysis.The COPII pathway and hematologic diseaseCharacterization of vitamin K-dependent carboxylase mutations that cause bleeding and nonbleeding disorders.Co-existent pseudoxanthoma elasticum and vitamin K-dependent coagulation factor deficiency: compound heterozygosity for mutations in the GGCX gene.Zebrafish vitamin K epoxide reductases: expression in vivo, along extracellular matrix mineralization and under phylloquinone and warfarin in vitro exposure.Functional Study of the Vitamin K Cycle Enzymes in Live Cells.Methylation of γ-carboxylated Glu (Gla) allows detection by liquid chromatography-mass spectrometry and the identification of Gla residues in the γ-glutamyl carboxylase.The mineralization phenotype in Abcc6 ( -/- ) mice is affected by Ggcx gene deficiency and genetic background--a model for pseudoxanthoma elasticumOsteoblast-Specific γ-Glutamyl Carboxylase-Deficient Mice Display Enhanced Bone Formation With Aberrant Mineralization.Gamma-glutamyl carboxylase and its influence on warfarin dose.VKOR paralog VKORC1L1 supports vitamin K-dependent protein carboxylation in vivo.Warfarin alters vitamin K metabolism: a surprising mechanism of VKORC1 uncoupling necessitates an additional reductase.
P2860
Q24304387-96EA322B-8635-4B9D-843F-2E924EB37C0EQ24338572-FFF13F06-85C3-4A00-8E67-0F12AC151F4BQ28086880-589840BF-7B23-40CF-8350-62A0F3FF7683Q28114887-C7BBAE83-357B-4269-8A54-8F09F9780E7FQ35092888-FC9485CA-A292-4B62-9335-72513615791AQ35639926-A9241D84-32A6-42EF-BEEA-5C54D93B5D1DQ36079805-0D63F77C-F046-4CFF-818F-CF5F15ED8282Q36800446-89B78385-6F89-41B6-984E-D7759CABF433Q37071882-43BBC67D-2A49-4F27-B77D-1CDF524FADB9Q38300335-852AB313-C7D9-40EC-9E6B-A5FC95F1F1E8Q39074534-B794A6F7-2458-41CB-8E46-77878D07E1DDQ39358254-DDB49685-83E3-43D5-A414-70F1EE497381Q40847416-EB23D4FF-15B3-4A4A-AAB0-8E85CED704AEQ46282207-FA405866-593E-4A89-9E95-B93F80B832A7Q49811574-56D79FA4-F527-402F-8CDD-C2B241098DE7Q50101823-9716622E-2E95-4326-AE0D-F1A4657ACC45Q51733284-296D626C-784E-47B7-8C00-E8509CDD27FF
P2860
Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase.
@ast
Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase.
@en
type
label
Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase.
@ast
Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase.
@en
prefLabel
Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase.
@ast
Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase.
@en
P2093
P2860
P1433
P1476
Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase.
@en
P2093
Barbara C Furie
Bruce Furie
David Ginsburg
Hongmin Sun
Mila Bronstein
Randal J Kaufman
Randal Westrick
Richard M Raymond
P2860
P304
P356
10.1182/BLOOD-2006-12-064188
P407
P577
2007-02-27T00:00:00Z