Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase. - Test2 - elhamkhani - TriplyDB

Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase.

Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase.

http://www.wikidata.org/entity/Q35839891

about

Novel insight into the mechanism of the vitamin K oxidoreductase (VKOR): electron relay through Cys43 and Cys51 reduces VKOR to allow vitamin K reduction and facilitation of vitamin K-dependent protein carboxylation Cytochrome P450-dependent catabolism of vitamin K: ω-hydroxylation catalyzed by human CYP4F2 and CYP4F11 Structural and functional insights into enzymes of the vitamin K cycle VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy Liver-specific γ-glutamyl carboxylase-deficient mice display bleeding diathesis and short life span.The vitamin K-dependent carboxylase generates γ-carboxylated glutamates by using CO2 to facilitate glutamate deprotonation in a concerted mechanism that drives catalysis.The COPII pathway and hematologic disease Characterization of vitamin K-dependent carboxylase mutations that cause bleeding and nonbleeding disorders.Co-existent pseudoxanthoma elasticum and vitamin K-dependent coagulation factor deficiency: compound heterozygosity for mutations in the GGCX gene.Zebrafish vitamin K epoxide reductases: expression in vivo, along extracellular matrix mineralization and under phylloquinone and warfarin in vitro exposure.Functional Study of the Vitamin K Cycle Enzymes in Live Cells.Methylation of γ-carboxylated Glu (Gla) allows detection by liquid chromatography-mass spectrometry and the identification of Gla residues in the γ-glutamyl carboxylase.The mineralization phenotype in Abcc6 ( -/- ) mice is affected by Ggcx gene deficiency and genetic background--a model for pseudoxanthoma elasticum Osteoblast-Specific γ-Glutamyl Carboxylase-Deficient Mice Display Enhanced Bone Formation With Aberrant Mineralization.Gamma-glutamyl carboxylase and its influence on warfarin dose.VKOR paralog VKORC1L1 supports vitamin K-dependent protein carboxylation in vivo.Warfarin alters vitamin K metabolism: a surprising mechanism of VKORC1 uncoupling necessitates an additional reductase.

P2860

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P2860

Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase.

http://www.wikidata.org/entity/Q35839891

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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name

Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase.

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Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase.

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Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase.

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Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase.

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Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase.

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Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase.

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Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase.

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Aihua Zhu

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Barbara C Furie

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Bruce Furie

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David Ginsburg

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Hongmin Sun

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Mila Bronstein

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Randal J Kaufman

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Randal Westrick

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Richard M Raymond

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P2860

A missense mutation in gamma-glutamyl carboxylase gene causes combined deficiency of all vitamin K-dependent blood coagulation factors

Mutations in the gene encoding the human matrix Gla protein cause Keutel syndrome

Identification of two novel transmembrane gamma-carboxyglutamic acid proteins expressed broadly in fetal and adult tissues

A cluster of sulfatase genes on Xp22.3: mutations in chondrodysplasia punctata (CDPX) and implications for warfarin embryopathy

Primary structure and tissue distribution of two novel proline-rich gamma-carboxyglutamic acid proteins

Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in mice

Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins

Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2

Identification of the gene for vitamin K epoxide reductase

Familial multiple coagulation factor deficiencies: new biologic insight from rare genetic bleeding disorders

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