Amelioration of progressive renal injury by genetic manipulation of Klotho gene. - Test2 - elhamkhani - TriplyDB

Amelioration of progressive renal injury by genetic manipulation of Klotho gene.

Amelioration of progressive renal injury by genetic manipulation of Klotho gene.

http://www.wikidata.org/entity/Q35844644

about

Klotho and aging Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho Regulation and function of the FGF23/klotho endocrine pathways Klotho, phosphate and inflammation/ageing in chronic kidney disease Klotho: a humeral mediator in CSF and plasma that influences longevity and susceptibility to multiple complex disorders, including depression Fibroblast growth factor 23 enhances renal klotho abundance Mitochondria-specific accumulation of amyloid β induces mitochondrial dysfunction leading to apoptotic cell death Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism The GH/IGF-1 axis in ageing and longevity Decrease of Klotho in the kidney of streptozotocin-induced diabetic rats Klotho is associated with VEGF receptor-2 and the transient receptor potential canonical-1 Ca2+ channel to maintain endothelial integrity.A comparative transcriptome analysis identifying FGF23 regulated genes in the kidney of a mouse CKD model.PKCδ promotes high glucose induced renal tubular oxidative damage via regulating activation and translocation of p66Shc.Klotho deficiency causes vascular calcification in chronic kidney disease.Alive and well? Exploring disease by studying lifespan.Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice Systems biology of autosomal dominant polycystic kidney disease (ADPKD): computational identification of gene expression pathways and integrated regulatory networks.The demonstration of αKlotho deficiency in human chronic kidney disease with a novel synthetic antibody Elevated Klotho promoter methylation is associated with severity of chronic kidney disease Klotho depletion contributes to increased inflammation in kidney of the db/db mouse model of diabetes via RelA (serine)536 phosphorylation.Hyperlipidemia-associated renal damage decreases Klotho expression in kidneys from ApoE knockout mice Biomarkers of kidney injury and klotho in patients with atherosclerotic renovascular disease.Aging-related kidney damage is associated with a decrease in klotho expression and an increase in superoxide production.Cross talk between the renin-angiotensin-aldosterone system and vitamin D-FGF-23-klotho in chronic kidney disease Role of Klotho in aging, phosphate metabolism, and CKD.Investigating mechanisms of chronic kidney disease in mouse models Molecular basis of Klotho: from gene to function in aging Phosphate Metabolism in Cardiorenal Metabolic Disease.Klotho and kidney disease.Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective Klotho gene delivery ameliorates renal hypertrophy and fibrosis in streptozotocin-induced diabetic rats by suppressing the Rho-associated coiled-coil kinase signaling pathway.Phosphate and Klotho.Phosphate may promote CKD progression and attenuate renoprotective effect of ACE inhibition.Signaling and Damaging Functions of Free Radicals in Aging-Free Radical Theory, Hormesis, and TOR.Suppression of Klotho expression by protein-bound uremic toxins is associated with increased DNA methyltransferase expression and DNA hypermethylation.The emerging role of Klotho in clinical nephrology.Combined activation of the energy and cellular-defense pathways may explain the potent anti-senescence activity of methylene blue.Renal Production, Uptake, and Handling of Circulating αKlotho Klotho protects against mouse renal fibrosis by inhibiting Wnt signaling.Spironolactone ameliorates PIT1-dependent vascular osteoinduction in klotho-hypomorphic mice.

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P2860

Amelioration of progressive renal injury by genetic manipulation of Klotho gene.

http://www.wikidata.org/entity/Q35844644

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

Amelioration of progressive renal injury by genetic manipulation of Klotho gene.

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Amelioration of progressive renal injury by genetic manipulation of Klotho gene.

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type

label

Amelioration of progressive renal injury by genetic manipulation of Klotho gene.

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Amelioration of progressive renal injury by genetic manipulation of Klotho gene.

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prefLabel

Amelioration of progressive renal injury by genetic manipulation of Klotho gene.

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Amelioration of progressive renal injury by genetic manipulation of Klotho gene.

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Proceedings of the National Academy of Sciences of the United States of America

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Amelioration of progressive renal injury by genetic manipulation of Klotho gene.

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Minoru Satoh

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Naoki Kashihara

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Naruya Tomita

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Ping Xie

http://www.w3.org/2001/XMLSchema#string

Tamaki Sasaki

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Tamehachi Namikoshi

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Toshihiko Fujimori

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Yashpal S Kanwar

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Yoshisuke Haruna

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P2860

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Suppression of aging in mice by the hormone Klotho

Increased mitochondrial oxidative stress in the Sod2 (+/-) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis

Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice

Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

Regulation of angiogenesis by the aging suppressor gene klotho.

NAD(P)H oxidase and uncoupled nitric oxide synthase are major sources of glomerular superoxide in rats with experimental diabetic nephropathy.

Requirement of Rac1 in the development of cardiac hypertrophy.

Multi-organ characterization of mitochondrial genomic rearrangements in ad libitum and caloric restricted mice show striking somatic mitochondrial DNA rearrangements with age

Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication.

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104

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2007-02-07T00:00:00Z

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6518129

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17287345

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1892974

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