Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment. - Test2 - elhamkhani - TriplyDB

Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment.

Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment.

http://www.wikidata.org/entity/Q35853020

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Focus on Extracellular Vesicles: Exosomes and Their Role in Protein Trafficking and Biomarker Potential in Alzheimer's and Parkinson's Disease Vacuolar Protein Sorting Genes in Parkinson's Disease: A Re-appraisal of Mutations Detection Rate and Neurobiology of Disease Impact of lysosome status on extracellular vesicle content and release The phosphorylation of α-synuclein: development and implication for the mechanism and therapy of the Parkinson's disease The Interplay between Alpha-Synuclein Clearance and Spreading Toxic Oligomeric Alpha-Synuclein Variants Present in Human Parkinson's Disease Brains Are Differentially Generated in Mammalian Cell Models Aggregated Alpha-Synuclein Transfer Efficiently between Cultured Human Neuron-Like Cells and Localize to Lysosomes Altered Autophagy-Associated Genes Expression in T Cells of Oral Lichen Planus Correlated with Clinical Features A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation.Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans.Emerging roles of extracellular vesicles in neurodegenerative disorders: focus on HIV-associated neurological complications.Dementia with Lewy Bodies: Molecular Pathology in the Frontal Cortex in Typical and Rapidly Progressive Forms.Neuronal aggregates: formation, clearance, and spreading.Sorting out release, uptake and processing of alpha-synuclein during prion-like spread of pathology.Cystatin C as a potential therapeutic mediator against Parkinson's disease via VEGF-induced angiogenesis and enhanced neuronal autophagy in neurovascular units DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative-associated proteins.Cellular models for Parkinson's disease.Emerging nexus between RAB GTPases, autophagy and neurodegeneration.α-Synuclein-carrying extracellular vesicles in Parkinson's disease: deadly transmitters.Exosomes in the Pathology of Neurodegenerative Diseases.Autophagy and the endo/exosomal pathways in health and disease.Association of Parkinson's Disease GWAS-Linked Loci with Alzheimer's Disease in Han Chinese.Secretory carrier membrane protein 5 is an autophagy inhibitor that promotes the secretion of α-synuclein via exosome.Novel animal model defines genetic contributions for neuron-to-neuron transfer of α-synuclein.Upregulation of autophagy-related gene 5 protects dopaminergic neurons in a zebrafish model of Parkinson's disease.Extracellular Membrane Vesicles as Vehicles for Brain Cell-to-Cell Interactions in Physiological as well as Pathological Conditions.Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity.Human Neural Progenitor Transplantation Rescues Behavior and Reduces α-Synuclein in a Transgenic Model of Dementia with Lewy Bodies.Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype.Intercellular transfer of pathogenic α-synuclein by extracellular vesicles is induced by the lipid peroxidation product 4-hydroxynonenal.Alpha-synuclein oligomers: a new hope.SNCA Is a Functionally Low-Expressed Gene in Lung Adenocarcinoma.Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons.Less is more: Caloric regulation of neurogenesis and adult brain function.Autophagy regulates exosomal release of prions in neuronal cells.Chronic Caffeine Treatment Protects Against α-Synucleinopathy by Reestablishing Autophagy Activity in the Mouse Striatum.Limited effects of dysfunctional macroautophagy on the accumulation of extracellularly derived α-synuclein in oligodendroglia: implications for MSA pathogenesis.Import and Export of Misfolded α-Synuclein.The Exosomal/Total α-Synuclein Ratio in Plasma Is Associated With Glucocerebrosidase Activity and Correlates With Measures of Disease Severity in PD Patients.Unconventional Secretion and Intercellular Transfer of Mutant Huntingtin.

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Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment.

http://www.wikidata.org/entity/Q35853020

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Autophagy modulates SNCA/α-syn ...... ng a hostile microenvironment.

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Autophagy modulates SNCA/α-syn ...... ng a hostile microenvironment.

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Autophagy modulates SNCA/α-syn ...... ng a hostile microenvironment.

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Autophagy modulates SNCA/α-syn ...... ng a hostile microenvironment.

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Autophagy modulates SNCA/α-syn ...... ng a hostile microenvironment.

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Autophagy modulates SNCA/α-syn ...... ng a hostile microenvironment.

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Anne-Maria Poehler

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Holger Meixner

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Jochen Klucken

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Juergen Winkler

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Oldriska Chutna

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Philipp Spitzer

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Tiago Fleming Outeiro

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Verena Elisabeth Luise May

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Wei Xiang

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P2860

Guidelines for the use and interpretation of assays for monitoring autophagy

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

Rab11 promotes docking and fusion of multivesicular bodies in a calcium-dependent manner

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells.

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo

Alpha-synuclein in Lewy bodies

Chaperone-mediated autophagy markers in Parkinson disease brains

Staging of brain pathology related to sporadic Parkinson's disease

The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders

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2171-2192

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scholarly article

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10.4161/AUTO.36436

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12

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10

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Eliezer Masliah

Edward Rockenstein

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2014-01-01T00:00:00Z

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25484190

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4502760

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