Effector role reversal during evolution: the case of frataxin in Fe-S cluster biosynthesis.
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Chronochemistry in neurodegenerationEmerging critical roles of Fe-S clusters in DNA replication and repair.Functional reconstitution of mitochondrial Fe/S cluster synthesis on Isu1 reveals the involvement of ferredoxinStructural characterization of metal binding to a cold-adapted frataxinThe iron metallome in eukaryotic organismsTurning Escherichia coli into a Frataxin-Dependent OrganismMitochondrial Cysteine Desulfurase and ISD11 Coexpressed in Escherichia coli Yield Complex Containing Acyl Carrier ProteinFrataxin-bypassing Isu1: characterization of the bypass activity in cells and mitochondriaRole of IscX in iron-sulfur cluster biogenesis in Escherichia coliMolecular strategies of microbial iron assimilation: from high-affinity complexes to cofactor assembly systems.Overlapping binding sites of the frataxin homologue assembly factor and the heat shock protein 70 transfer factor on the Isu iron-sulfur cluster scaffold proteinHuman frataxin activates Fe-S cluster biosynthesis by facilitating sulfur transfer chemistry.Tangled web of interactions among proteins involved in iron-sulfur cluster assembly as unraveled by NMR, SAXS, chemical crosslinking, and functional studies.Molecular insights into frataxin-mediated iron supply for heme biosynthesis in Bacillus subtilisTurning Saccharomyces cerevisiae into a Frataxin-Independent Organism.Trading Places-Switching Frataxin Function by a Single Amino Acid Substitution within the [Fe-S] Cluster Assembly Scaffold.Crystal Structure of Bacillus subtilis Cysteine Desulfurase SufS and Its Dynamic Interaction with Frataxin and Scaffold Protein SufU.The Eukaryotic-Specific ISD11 Is a Complex-Orphan Protein with Ability to Bind the Prokaryotic IscSAnalyzing the Effects of a G137V Mutation in the FXN Gene.Frataxin Accelerates [2Fe-2S] Cluster Formation on the Human Fe-S Assembly ComplexIron-sulfur cluster synthesis, iron homeostasis and oxidative stress in Friedreich ataxia.Architecture of the Yeast Mitochondrial Iron-Sulfur Cluster Assembly Machinery: THE SUB-COMPLEX FORMED BY THE IRON DONOR, Yfh1 PROTEIN, AND THE SCAFFOLD, Isu1 PROTEIN.[2Fe-2S]-ferredoxin binds directly to cysteine desulfurase and supplies an electron for iron-sulfur cluster assembly but is displaced by the scaffold protein or bacterial frataxin.Human mitochondrial chaperone (mtHSP70) and cysteine desulfurase (NFS1) bind preferentially to the disordered conformation, whereas co-chaperone (HSC20) binds to the structured conformation of the iron-sulfur cluster scaffold protein (ISCU).Metamorphic protein IscU alternates conformations in the course of its role as the scaffold protein for iron-sulfur cluster biosynthesis and delivery.Distinct roles of the Salmonella enterica serovar Typhimurium CyaY and YggX proteins in the biosynthesis and repair of iron-sulfur clusters.Frataxin: a protein in search for a function.Understanding the role of dynamics in the iron sulfur cluster molecular machine.Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly MachineryThe iron-binding CyaY and IscX proteins assist the ISC-catalyzed Fe-S biogenesis in Escherichia coli.A helix-coil transition induced by the metal ion interaction with a grafted iron-binding site of the CyaY protein family.Apn1 AP-endonuclease is essential for the repair of oxidatively damaged DNA bases in yeast frataxin-deficient cells.In vitro characterization of a novel Isu homologue from Drosophila melanogaster for de novo FeS-cluster formation.Zinc and the iron donor frataxin regulate oligomerization of the scaffold protein to form new Fe-S cluster assembly centers.Structure of human Fe-S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP-ISD11 interactions.The Molecular Bases of the Dual Regulation of Bacterial Iron Sulfur Cluster Biogenesis by CyaY and IscX.FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur clusterInteractions of iron-bound frataxin with ISCU and ferredoxin on the cysteine desulfurase complex leading to Fe-S cluster assembly.Iron-sulfur clusters: from metals through mitochondria biogenesis to disease.Fe-S cluster assembly in the supergroup Excavata.
P2860
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P2860
Effector role reversal during evolution: the case of frataxin in Fe-S cluster biosynthesis.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Effector role reversal during ...... in Fe-S cluster biosynthesis.
@ast
Effector role reversal during ...... in Fe-S cluster biosynthesis.
@en
type
label
Effector role reversal during ...... in Fe-S cluster biosynthesis.
@ast
Effector role reversal during ...... in Fe-S cluster biosynthesis.
@en
prefLabel
Effector role reversal during ...... in Fe-S cluster biosynthesis.
@ast
Effector role reversal during ...... in Fe-S cluster biosynthesis.
@en
P2860
P356
P1433
P1476
Effector role reversal during ...... in Fe-S cluster biosynthesis.
@en
P2093
Clara Iannuzzi
Jennifer Bridwell-Rabb
P2860
P304
P356
10.1021/BI201628J
P407
P577
2012-03-15T00:00:00Z