The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity. - Test2 - elhamkhani - TriplyDB

The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity.

The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity.

http://www.wikidata.org/entity/Q35880387

about

Oncogenes strike a balance between cellular growth and homeostasis Ascorbate as a co-factor for fe- and 2-oxoglutarate dependent dioxygenases: physiological activity in tumor growth and progression Hydrogen peroxide sensing, signaling and regulation of transcription factors The ever-expanding role of HIF in tumour and stromal biology Molecular mechanisms of action and therapeutic uses of pharmacological inhibitors of HIF-prolyl 4-hydroxylases for treatment of ischemic diseases Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development.Antiangiogenic activity of phthalides-enriched Angelica Sinensis extract by suppressing WSB-1/pVHL/HIF-1α/VEGF signaling in bladder cancer.2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process.Insulin regulates hypoxia-inducible factor-1α transcription by reactive oxygen species sensitive activation of Sp1 in 3T3-L1 preadipocyte.Proline-hydroxylated hypoxia-inducible factor 1α (HIF-1α) upregulation in human tumours.HIF transcription factors, inflammation, and immunity.Peroxiredoxin-5 targeted to the mitochondrial intermembrane space attenuates hypoxia-induced reactive oxygen species signalling Redox regulation of genome stability by effects on gene expression, epigenetic pathways and DNA damage/repair.Low Molecular Weight Fucoidan Inhibits Tumor Angiogenesis through Downregulation of HIF-1/VEGF Signaling under Hypoxia.The updated biology of hypoxia-inducible factor Oxygen versus Reactive Oxygen in the Regulation of HIF-1α: The Balance Tips Oxidative Dimerization of PHD2 is Responsible for its Inactivation and Contributes to Metabolic Reprogramming via HIF-1α Activation O2 sensing, mitochondria and ROS signaling: The fog is lifting Monoamine oxidase B levels are highly expressed in human gliomas and are correlated with the expression of HiF-1α and with transcription factors Sp1 and Sp3.Redox control of inflammation in macrophages.Signaling hypoxia by hypoxia-inducible factor protein hydroxylases: a historical overview and future perspectives Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer.Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways Cell cycle progression in response to oxygen levels.Regulation of hypoxia-inducible factor-1a by reactive oxygen species: new developments in an old debate.Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases.The role of HIF-1 in oncostatin M-dependent metabolic reprogramming of hepatic cells Renal erythropoietin-producing cells in health and disease.Molecular mechanisms of hypoxia-inducible factor-induced pulmonary arterial smooth muscle cell alterations in pulmonary hypertension.Current advances in the novel functions of hypoxia-inducible factor and prolyl hydroxylase in invertebrates.The role of HIFs in ischemia-reperfusion injury.Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism.Strange Bedfellows: Nuclear Factor, Erythroid 2-Like 2 (Nrf2) and Hypoxia-Inducible Factor 1 (HIF-1) in Tumor Hypoxia.Determinants of hypoxia inducible factor (HIF) activity in the intestinal mucosa.Redox signaling during hypoxia in mammalian cells.Regulation of immunity and inflammation by hypoxia in immunological niches.Hypoxia Pathway Proteins As Central Mediators of Metabolism in the Tumor Cells and Their Microenvironment.Preconditioning of Cardiosphere-Derived Cells With Hypoxia or Prolyl-4-Hydroxylase Inhibitors Increases Stemness and Decreases Reliance on Oxidative Metabolism.

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P2860

The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity.

http://www.wikidata.org/entity/Q35880387

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

The FIH hydroxylase is a cellu ...... HIF transcriptional activity.

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The FIH hydroxylase is a cellu ...... HIF transcriptional activity.

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The FIH hydroxylase is a cellu ...... HIF transcriptional activity.

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The FIH hydroxylase is a cellu ...... HIF transcriptional activity.

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The FIH hydroxylase is a cellu ...... HIF transcriptional activity.

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The FIH hydroxylase is a cellu ...... HIF transcriptional activity.

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P2093

David C Trudgian

http://www.w3.org/2001/XMLSchema#string

Lucy J Ambrose

http://www.w3.org/2001/XMLSchema#string

Melroy X Miranda

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Norma Masson

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Rok Sekirnik

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P2860

Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

Oxygen sensing by HIF hydroxylases

The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism

Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors

Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation

Quantitative mass spectrometry reveals dynamics of factor-inhibiting hypoxia-inducible factor-catalyzed hydroxylation.

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251-257

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scholarly article

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10.1038/EMBOR.2012.9

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3

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13

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Peter J. Ratcliffe

Christopher J. Schofield

Benedikt M. Kessler

Rachelle S Singleton

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2012-03-01T00:00:00Z

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221810719

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22310300

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3323130

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