Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases.
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Mitochondrial metabolic remodeling in response to genetic and environmental perturbationsDefects in mitochondrial metabolism and cancerMetabolic consequences of oncogenic IDH mutationsVitamin C in Stem Cell Biology: Impact on Extracellular Matrix Homeostasis and Epigenetics.Molecular markers of paragangliomas/pheochromocytomasKinetic Investigations of the Role of Factor Inhibiting Hypoxia-inducible Factor (FIH) as an Oxygen Sensor.TET proteins and 5-methylcytosine oxidation in hematological cancersMetabolic profiling reveals potential metabolic markers associated with Hypoxia Inducible Factor-mediated signalling in hypoxic cancer cells2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.Expression of Idh1(R132H) in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis.Alpha-Ketoglutarate as a Molecule with Pleiotropic Activity: Well-Known and Novel Possibilities of Therapeutic UseOncometabolites-driven tumorigenesis: From genetics to targeted therapy.Genetically modeled mice with mutations in mitochondrial metabolic enzymes for the study of cancerProlyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses.Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions.Tissue mechanics promote IDH1-dependent HIF1α-tenascin C feedback to regulate glioblastoma aggression.Identification of a novel inactivating mutation in Isocitrate Dehydrogenase 1 (IDH1-R314C) in a high grade astrocytoma.Oxygen availability and metabolic adaptations.L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pHMetabolism, Activity, and Targeting of D- and L-2-Hydroxyglutarates.Metabolic implications of hypoxia and pseudohypoxia in pheochromocytoma and paraganglioma.Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials.Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis.Coupling between d-3-phosphoglycerate dehydrogenase and d-2-hydroxyglutarate dehydrogenase drives bacterial l-serine synthesis.Inhibitors of both the N-methyl lysyl- and arginyl-demethylase activities of the JmjC oxygenases.Hypoxic Signalling in Tumour Stroma.Hypercapnia Alters Expression of Immune Response, Nucleosome Assembly and Lipid Metabolism Genes in Differentiated Human Bronchial Epithelial Cells
P2860
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P2860
Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年学术文章
@wuu
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
@yue
2014年學術文章
@zh
2014年學術文章
@zh-hant
name
Non-enzymatic chemistry enable ...... of 2-oxoglutarate oxygenases.
@en
type
label
Non-enzymatic chemistry enable ...... of 2-oxoglutarate oxygenases.
@en
prefLabel
Non-enzymatic chemistry enable ...... of 2-oxoglutarate oxygenases.
@en
P2093
P2860
P50
P356
P1476
Non-enzymatic chemistry enable ...... n of 2-oxoglutarate oxygenases
@en
P2093
Hanna Tarhonskaya
Mun Chiang Chan
Nikita D Loik
Timothy D W Claridge
P2860
P2888
P356
10.1038/NCOMMS4423
P407
P50
P577
2014-03-05T00:00:00Z
P5875
P6179
1027151439