Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. - Test2 - elhamkhani - TriplyDB

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.

http://www.wikidata.org/entity/Q35916172

about

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells A high-coverage genome sequence from an archaic Denisovan individual Physiologic characterization of type 2 diabetes-related loci Transcription factor 7-like 2 polymorphism and colon cancer Pharmacogenetic studies update in type 2 diabetes mellitus Genetics of Insulin Resistance and the Metabolic Syndrome Novel phenotypes of prediabetes?Dissecting diabetes/metabolic disease mechanisms using pluripotent stem cells and genome editing tools The association between the rs11196218A/G polymorphism of the TCF7L2 gene and type 2 diabetes in the Chinese Han population: a meta-analysis Cell-context dependent TCF/LEF expression and function: alternative tales of repression, de-repression and activation potentials Using gene-network landscape to dissect genotype effects of TCF7L2 genetic variant on diabetes and cardiovascular risk Polymorphism of the Transcription Factor 7-Like 2 Gene (TCF7L2) Interacts with Obesity on Type-2 Diabetes in the PREDIMED Study Emphasizing the Heterogeneity of Genetic Variants in Type-2 Diabetes Risk Prediction: Time for Obesity-Specific Genetic R Differential methylation of TCF7L2 promoter in peripheral blood DNA in newly diagnosed, drug-naïve patients with type 2 diabetes TCF7L2 modulates glucose homeostasis by regulating CREB- and FoxO1-dependent transcriptional pathway in the liver Human-specific derived alleles of CD33 and other genes protect against postreproductive cognitive decline Evaluation of fasting state-/oral glucose tolerance test-derived measures of insulin release for the detection of genetically impaired β-cell function Genome-wide association studies in type 2 diabetes Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge A novel TCF7L2 type 2 diabetes SNP identified from fine mapping in African American women.Bridging the gap between genetic associations and molecular mechanisms for type 2 diabetes.Nutrigenetics and nutrigenomics insights into diabetes etiopathogenesis.Association of fibrillin-3 and transcription factor-7-like 2 gene variants with metabolic phenotypes in PCOS.Islet specific Wnt activation in human type II diabetes.Data interpretation: deciphering the biological function of Type 2 diabetes associated risk loci.TCF7L2 polymorphism rs7903146 is associated with coronary artery disease severity and mortality The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies.Weak or no association of TCF7L2 variants with Type 2 diabetes risk in an Arab population.TCF7L2 variant genotypes and type 2 diabetes risk in Brazil: significant association, but not a significant tool for risk stratification in the general population.Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data Alternative splicing of TCF7L2 gene in omental and subcutaneous adipose tissue and risk of type 2 diabetes.Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS).Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps.β-cell mass in people with type 2 diabetes.TCF7L2 polymorphism associates with new-onset diabetes after transplantation.Genetics of type 2 diabetes: insights into the pathogenesis and its clinical application.TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action.Type 2 diabetes susceptibility gene expression in normal or diabetic sorted human alpha and beta cells: correlations with age or BMI of islet donors.Differential transcriptional and posttranslational transcription factor 7-like regulation among nondiabetic individuals and type 2 diabetic patients.

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Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.

http://www.wikidata.org/entity/Q35916172

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.

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Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.

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Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.

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Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.

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Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.

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Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.

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Journal of Clinical Investigation

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Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.

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Asa-Linda Lethagen

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Göran Berglund

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Karl-Fredrik Eriksson

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Marketa Sjögren

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Peter Almgren

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Peter Nilsson

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Rita Mancarella

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Roberto Lupi

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P2860

Genetic prediction of future type 2 diabetes

The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

A genome-wide association study identifies novel risk loci for type 2 diabetes

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

A variant in CDKAL1 influences insulin response and risk of type 2 diabetes

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2155-2163

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10.1172/JCI30706

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8

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117

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Tiinamaija Tuomi

Valeriya Lyssenko

Marju Orho-Melander

Silvia Del Guerra

Piero Marchetti

Stefano Del Prato

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2007-08-01T00:00:00Z

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6166970

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17671651

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type-2 diabetes

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1934596

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