Attention deficit/hyperactivity disorder-derived coding variation in the dopamine transporter disrupts microdomain targeting and trafficking regulation.
about
Amphetamine modulates excitatory neurotransmission through endocytosis of the glutamate transporter EAAT3 in dopamine neuronsMechanisms of dopamine transporter regulation in normal and disease statesDefining the blanks--pharmacochaperoning of SLC6 transporters and ABC transportersSpontaneous inward opening of the dopamine transporter is triggered by PIP2-regulated dynamics of the N-terminusAmphetamine activates Rho GTPase signaling to mediate dopamine transporter internalization and acute behavioral effects of amphetamine.Membrane potential shapes regulation of dopamine transporter trafficking at the plasma membraneAntipsychotic drug-like effects of the selective M4 muscarinic acetylcholine receptor positive allosteric modulator VU0152100The rare DAT coding variant Val559 perturbs DA neuron function, changes behavior, and alters in vivo responses to psychostimulants.Missense dopamine transporter mutations associate with adult parkinsonism and ADHD.Kinase-dependent Regulation of Monoamine Neurotransmitter Transporters.Genetic targeting of the amphetamine and methylphenidate-sensitive dopamine transporter: on the path to an animal model of attention-deficit hyperactivity disorder.Dopamine transporter endocytic trafficking in striatal dopaminergic neurons: differential dependence on dynamin and the actin cytoskeleton.Insights in how amphetamine ROCKs (Rho-associated containing kinase) membrane protein trafficking.Computational modeling of the N-terminus of the human dopamine transporter and its interaction with PIP2 -containing membranes.Regulation of the Dopamine and Vesicular Monoamine Transporters: Pharmacological Targets and Implications for Disease.Drosophila melanogaster as a genetic model system to study neurotransmitter transporters.SLC6A3 coding variant Ala559Val found in two autism probands alters dopamine transporter function and trafficking.Long Withdrawal of Methylphenidate Induces a Differential Response of the Dopaminergic System and Increases Sensitivity to Cocaine in the Prefrontal Cortex of Spontaneously Hypertensive Rats.Functional mechanisms of neurotransmitter transporters regulated by lipid-protein interactions of their terminal loops.Amphetamines, new psychoactive drugs and the monoamine transporter cycle.Reciprocal Phosphorylation and Palmitoylation Control Dopamine Transporter Kinetics.Nonoisotopic assay for the presynaptic choline transporter reveals capacity for allosteric modulation of choline uptake.Ack1 is a dopamine transporter endocytic brake that rescues a trafficking-dysregulated ADHD coding variant.A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporterDifferential targeting of the dopamine transporter to recycling or degradative pathways during amphetamine- or PKC-regulated endocytosis in dopamine neurons.Membrane-permeable C-terminal dopamine transporter peptides attenuate amphetamine-evoked dopamine release.Transgenic mouse models for ADHD.A literature search tool for intelligent extraction of disease-associated genes.Quantum dot approaches for target-based drug screening and multiplexed active biosensing.A review of the pathophysiology, etiology, and treatment of attention-deficit hyperactivity disorder (ADHD).Neuron membrane trafficking and protein kinases involved in autism and ADHD.The Atypical MAP Kinase SWIP-13/ERK8 Regulates Dopamine Transporters Through a Rho-Dependent Mechanism.Sequence determinants of the Caenhorhabditis elegans dopamine transporter dictating in vivo axonal export and synaptic localization.Dopamine Transporter Amino and Carboxyl Termini Synergistically Contribute to Substrate and Inhibitor Affinities.A microfluidic method for dopamine uptake measurements in dopaminergic neurons.HIV, Tat and dopamine transmission.Membrane transporters as mediators of synaptic dopamine dynamics: implications for disease.Single-quantum-dot tracking reveals altered membrane dynamics of an attention-deficit/hyperactivity-disorder-derived dopamine transporter coding variant.Palmitoylation mechanisms in dopamine transporter regulation.Exploring the Validity of Proposed Transgenic Animal Models of Attention-Deficit Hyperactivity Disorder (ADHD).
P2860
Q24563448-FA2C4FEF-B7A2-4CDA-AB0A-F85B4F255638Q24598750-26566165-C3D1-4DCC-9342-B15AE42C1495Q26825537-AB8076AB-260F-40BB-9537-D46E609184C8Q27300323-2E2E8692-BF3C-4B3D-A946-ABADFF998268Q27320548-C5021C73-0D97-4F75-9356-5893F11E4754Q27334784-1CDB860D-FDC0-49C1-BEFB-3253A4C6981EQ30410518-5379C6B7-F439-4743-B6B4-57CC565B98C5Q30412810-CAF71C93-503A-49B6-B9A1-BE5262560685Q30581669-6A5E9AED-6B2A-4FB1-9278-37B951CCB47EQ34161514-AFDFA720-E341-474D-BC26-C506E447C3CDQ34257043-2984B283-24A3-4B61-9666-BCB53DFDA1B1Q34383082-1E3AEA90-FB81-4A1E-A7FA-6B57011406DDQ34503074-755A9966-4552-4BA9-A1D6-6F3B0FB2C848Q34668331-6C1318B1-8A03-4EF3-8F8A-86BF653B759CQ34673305-EE816878-E934-489E-963A-CA2AF7CC0644Q34690868-8EBACF87-BB3F-467C-9F9B-C5FF59FC1A0BQ35150201-456EFA5B-6001-49D8-B59B-7CB9AC8B904BQ35824437-8FC52D79-2081-4878-B751-E0F0A0D449EFQ35850518-25508046-974F-40B7-BAB3-8901F223F221Q35853599-6BD8883A-8DED-4CE2-9616-8A6E3A5658ABQ36323546-9C440DC2-18B5-47E9-A16F-4CFB9E5924F9Q36326822-771BA94B-67C8-425E-A300-B3DAFCC0B27AQ36394226-8279CD48-2F3B-4C5C-812C-321778B4077BQ36822479-32825843-8722-475E-BF4D-5AF11EB2E913Q37022861-EFF89E65-605E-4DEC-B15C-6D3A40D35854Q37189583-D484AD76-5CCB-4591-BE20-791D44858AEDQ37203801-3141A5EB-2F5D-457C-AE96-431003D7D2EFQ37715375-5C9E5B62-9715-413B-9931-A11810047B3CQ38129020-2D3C300F-3378-46F9-9161-2D2B52EB0958Q38164670-0F4D54A4-843D-42C7-B83F-5B89590F3F16Q38342576-FDCF9FED-D41D-4F95-8F0F-53B190BE169AQ38429066-9EC5EF61-1AAF-486C-9944-ACED03F1259DQ38434567-F8637169-E4F6-4BAE-8533-2FD106B9B9D5Q38725778-BE4036F6-472C-421C-8A92-C81A623C5073Q38806889-08F4F678-AC14-449B-88AE-B5BC794DB97FQ38812005-3117BE5A-B39F-49CF-9D5A-740E35E9FE94Q38926644-669AA2CA-73F3-45E7-BBD0-7C6C74AB72C5Q39032059-A89D0D8C-4230-4CF4-83B1-ADAC664F9FE3Q39099468-AD4425E2-BB16-4C5E-A5EA-1A31703C76B1Q39324205-3D4EC29B-7575-48DA-A162-0840BCED828B
P2860
Attention deficit/hyperactivity disorder-derived coding variation in the dopamine transporter disrupts microdomain targeting and trafficking regulation.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Attention deficit/hyperactivit ...... ng and trafficking regulation.
@ast
Attention deficit/hyperactivit ...... ng and trafficking regulation.
@en
type
label
Attention deficit/hyperactivit ...... ng and trafficking regulation.
@ast
Attention deficit/hyperactivit ...... ng and trafficking regulation.
@en
prefLabel
Attention deficit/hyperactivit ...... ng and trafficking regulation.
@ast
Attention deficit/hyperactivit ...... ng and trafficking regulation.
@en
P2093
P2860
P50
P1476
Attention deficit/hyperactivit ...... ng and trafficking regulation.
@en
P2093
Aurelio Galli
Erica Bowton
Marc A Mergy
Nathan W Richtand
Peter J Hamilton
Randy D Blakely
P2860
P304
P356
10.1523/JNEUROSCI.6033-11.2012
P407
P577
2012-04-01T00:00:00Z