Spontaneous inward opening of the dopamine transporter is triggered by PIP2-regulated dynamics of the N-terminus
about
Molecular dynamics simulations of membrane proteins and their interactions: from nanoscale to mesoscaleMapping Cholesterol Interaction Sites on Serotonin Transporter through Coarse-Grained Molecular DynamicsTargeting of dopamine transporter to filopodia requires an outward-facing conformation of the transporter.Computational approaches to detect allosteric pathways in transmembrane molecular machines.A Markov State-based Quantitative Kinetic Model of Sodium Release from the Dopamine Transporter.Dopamine Transporter Amino and Carboxyl Termini Synergistically Contribute to Substrate and Inhibitor Affinities.Electrogenic Binding of Intracellular Cations Defines a Kinetic Decision Point in the Transport Cycle of the Human Serotonin Transporter.Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu290Lipid interaction sites on channels, transporters and receptors: Recent insights from molecular dynamics simulations.The N Terminus Specifies the Switch between Transport Modes of the Human Serotonin Transporter.An engineered opsin monomer scrambles phospholipids.Mechanisms of Lipid Scrambling by the G Protein-Coupled Receptor Opsin.Latch and trigger role for R445 in DAT transport explains molecular basis of DTDS.Quantitative Assessment of the Energetics of Dopamine Translocation by Human Dopamine Transporter.Thermodynamic Coupling Function Analysis of Allosteric Mechanisms in the Human Dopamine Transporter.Allosteric modulation of human dopamine transporter activity under conditions promoting its dimerization.Effect of Dimerization on the Dynamics of Neurotransmitter:Sodium Symporters.The role of transmembrane segment 5 (TM5) in Na2 release and the conformational transition of neurotransmitter:sodium symporters toward the inward-open state.Molecular dynamics of conformation-specific dopamine transporter-inhibitor complexes.A direct interaction of cholesterol with the dopamine transporter prevents its out-to-inward transition.Heterogeneities in Axonal Structure and Transporter Distribution Lower Dopamine Reuptake Efficiency.Mechanistic Insights into the Stimulant Properties of Novel Psychoactive Substances (NPS) and Their Discrimination by the Dopamine Transporter-In Silico and In Vitro Exploration of Dissociative Diarylethylamines.Shared dynamics of LeuT superfamily members and allosteric differentiation by structural irregularities and multimerization.How structural elements evolving from bacterial to human SLC6 transporters enabled new functional properties.Direct protein-lipid interactions shape the conformational landscape of secondary transportersGating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase
P2860
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P2860
Spontaneous inward opening of the dopamine transporter is triggered by PIP2-regulated dynamics of the N-terminus
description
2015 nî lūn-bûn
@nan
2015 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Spontaneous inward opening of ...... ted dynamics of the N-terminus
@ast
Spontaneous inward opening of ...... ted dynamics of the N-terminus
@en
Spontaneous inward opening of ...... ted dynamics of the N-terminus
@nl
type
label
Spontaneous inward opening of ...... ted dynamics of the N-terminus
@ast
Spontaneous inward opening of ...... ted dynamics of the N-terminus
@en
Spontaneous inward opening of ...... ted dynamics of the N-terminus
@nl
prefLabel
Spontaneous inward opening of ...... ted dynamics of the N-terminus
@ast
Spontaneous inward opening of ...... ted dynamics of the N-terminus
@en
Spontaneous inward opening of ...... ted dynamics of the N-terminus
@nl
P2093
P2860
P50
P1476
Spontaneous inward opening of ...... ted dynamics of the N-terminus
@en
P2093
George Khelashvili
Gianni De Fabritiis
Jaime Medina
Michelle A Sahai
Nathaniel Stanley
P2860
P304
P356
10.1021/ACSCHEMNEURO.5B00179
P407
P577
2015-08-17T00:00:00Z