Two crystal structures of dihydrofolate reductase-thymidylate synthase from Cryptosporidium hominis reveal protein-ligand interactions including a structural basis for observed antifolate resistance.
about
Synthetic and Crystallographic Studies of a New Inhibitor Series Targeting Bacillus anthracis Dihydrofolate ReductaseTargeting purine and pyrimidine metabolism in human apicomplexan parasitesAutomated NMR Assignment and Protein Structure Determination using Sparse Dipolar Coupling Constraints.Electrostatic channeling in P. falciparum DHFR-TS: Brownian dynamics and Smoluchowski modeling.Structure-based approach to the development of potent and selective inhibitors of dihydrofolate reductase from cryptosporidium.Three-dimensional structures in the design of therapeutics targeting parasitic protozoa: reflections on the past, present and future.Diffusional channeling in the sulfate-activating complex: combined continuum modeling and coarse-grained brownian dynamics studiesTowards new antifolates targeting eukaryotic opportunistic infectionsIn pursuit of virtual lead optimization: the role of the receptor structure and ensembles in accurate docking.Structural studies provide clues for analog design of specific inhibitors of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase.Study on Folate Binding Domain of Dihydrofolate Reductase in Different Plant species and Human beings.In pursuit of virtual lead optimization: pruning ensembles of receptor structures for increased efficiency and accuracy during docking.
P2860
Q27652892-C715E1B5-EDEA-40A8-924F-1B27CDCE43DBQ28629739-FCEA99F8-4D90-43F0-9EE4-AB9497CC3643Q30385726-2E64C6E0-30C9-4F39-A510-ABBA880B3741Q34561303-7D715953-D8D9-434A-91BA-8AAD28ADD4A9Q34657298-242834C4-9861-4457-A1D2-753ED0BE2DC0Q35592514-A0CD0968-5733-4F28-A2CD-0C53DD5A5948Q36957406-F7274510-E6C0-43FC-A1BF-836DE136F956Q37158762-72D6A775-E07B-4CD5-9E79-E90523407CBBQ40419101-B2849E72-B4DB-41E7-BDFD-179ADF32A0DFQ40524360-79C12136-536C-478B-962D-41358CE55CCCQ41984105-6CD3ED07-EE7C-4D26-9EEE-F7F18C05F72DQ43170586-E050F1D0-206C-4F89-876D-E41D4CC5506A
P2860
Two crystal structures of dihydrofolate reductase-thymidylate synthase from Cryptosporidium hominis reveal protein-ligand interactions including a structural basis for observed antifolate resistance.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Two crystal structures of dihy ...... bserved antifolate resistance.
@ast
Two crystal structures of dihy ...... bserved antifolate resistance.
@en
type
label
Two crystal structures of dihy ...... bserved antifolate resistance.
@ast
Two crystal structures of dihy ...... bserved antifolate resistance.
@en
prefLabel
Two crystal structures of dihy ...... bserved antifolate resistance.
@ast
Two crystal structures of dihy ...... bserved antifolate resistance.
@en
P2860
P1476
Two crystal structures of dihy ...... bserved antifolate resistance.
@en
P2093
Amy C Anderson
P2860
P304
P356
10.1107/S1744309105002435
P577
2005-02-08T00:00:00Z