Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21
about
E2 enzymes: more than just middle menTRIM21: a cytosolic Fc receptor with broad antibody isotype specificityCoordinated Neutralization and Immune Activation by the Cytosolic Antibody Receptor TRIM21Deubiquitinating enzymes Ubp2 and Ubp15 regulate endocytosis by limiting ubiquitination and degradation of ARTsDelicate coordination of TRIM21's dual activity in virus neutralization and signaling.TRIM5 Retroviral Restriction Activity Correlates with the Ability To Induce Innate Immune Signaling.TRIM5α-Mediated Ubiquitin Chain Conjugation Is Required for Inhibition of HIV-1 Reverse Transcription and Capsid Destabilization.Defects in lysosomal maturation facilitate the activation of innate sensors in systemic lupus erythematosus.Nonhuman TRIM5 Variants Enhance Recognition of HIV-1-Infected Cells by CD8+ T Cells.Mouse and human FcR effector functions.TRIM21 Immune Signaling Is More Sensitive to Antibody Affinity Than Its Neutralization ActivityRo52/TRIM21-deficient expression and function in different subsets of peripheral blood mononuclear cells is associated with a proinflammatory cytokine response in patients with idiopathic inflammatory myopathies.Ubiquitin enzymes in the regulation of immune responses.The TRIMendous Role of TRIMs in Virus-Host Interactions.Antibody-antigen kinetics constrain intracellular humoral immunity.A Method for the Acute and Rapid Degradation of Endogenous Proteins.Autoantibodies against the Immunoglobulin-Binding Region of Ro52 Link its Autoantigenicity with Pathogen Neutralization.POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity
P2860
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P2860
Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Sequential ubiquitination and ...... d effector functions of TRIM21
@ast
Sequential ubiquitination and ...... d effector functions of TRIM21
@en
type
label
Sequential ubiquitination and ...... d effector functions of TRIM21
@ast
Sequential ubiquitination and ...... d effector functions of TRIM21
@en
prefLabel
Sequential ubiquitination and ...... d effector functions of TRIM21
@ast
Sequential ubiquitination and ...... d effector functions of TRIM21
@en
P2093
P2860
P356
P1476
Sequential ubiquitination and ...... d effector functions of TRIM21
@en
P2093
Adam J Fletcher
Claire F Dickson
Donna L Mallery
Leo C James
P2860
P304
10014-10019
P356
10.1073/PNAS.1507534112
P407
P577
2015-07-06T00:00:00Z