XRad17 is required for the activation of XChk1 but not XCds1 during checkpoint signaling in Xenopus.
about
Xenopus Cds1 is regulated by DNA-dependent protein kinase and ATR during the cell cycle checkpoint response to double-stranded DNA endsThe phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATR-dependent activation of Chk1.Rad17 plays a central role in establishment of the interaction between TopBP1 and the Rad9-Hus1-Rad1 complex at stalled replication forksRole of replication protein A as sensor in activation of the S-phase checkpoint in Xenopus egg extracts.Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminusThe Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forksAbsence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phasesAnalyzing the ATR-mediated checkpoint using Xenopus egg extractsTopBP1 and DNA polymerase-alpha directly recruit the 9-1-1 complex to stalled DNA replication forks.Cip29 is phosphorylated following activation of the DNA damage response in Xenopus egg extracts.Deregulated replication licensing causes DNA fragmentation consistent with head-to-tail fork collision.APE2 promotes DNA damage response pathway from a single-strand break.
P2860
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P2860
XRad17 is required for the activation of XChk1 but not XCds1 during checkpoint signaling in Xenopus.
description
2003 nî lūn-bûn
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2003年の論文
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2003年論文
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2003年論文
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2003年論文
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name
XRad17 is required for the act ...... eckpoint signaling in Xenopus.
@ast
XRad17 is required for the act ...... eckpoint signaling in Xenopus.
@en
type
label
XRad17 is required for the act ...... eckpoint signaling in Xenopus.
@ast
XRad17 is required for the act ...... eckpoint signaling in Xenopus.
@en
prefLabel
XRad17 is required for the act ...... eckpoint signaling in Xenopus.
@ast
XRad17 is required for the act ...... eckpoint signaling in Xenopus.
@en
P2093
P2860
P356
P1476
XRad17 is required for the act ...... eckpoint signaling in Xenopus.
@en
P2093
Antony M Car
Chandrakala Puligilla
Christopher C Ford
Howard D Lindsay
J Ross Chapman
Johanne M Murray
Rhiannon E Jones
P2860
P304
P356
10.1091/MBC.E03-03-0138
P577
2003-05-18T00:00:00Z