A human homologue of the Schizosaccharomyces pombe rad1+ checkpoint gene encodes an exonuclease
about
Human homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complexThe human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiationHuman DNA damage checkpoint protein hRAD9 is a 3' to 5' exonucleaseThe human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9Structure and expression of the TREX1 and TREX2 3' --> 5' exonuclease genesExcision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteinsc-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damageProtein kinase Cdelta is responsible for constitutive and DNA damage-induced phosphorylation of Rad9Identification of a human homologue of the Schizosaccharomyces pombe rad17+ checkpoint geneMultiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiaeA CAF-1-PCNA-mediated chromatin assembly pathway triggered by sensing DNA damagePurification and characterization of human DNA damage checkpoint Rad complexesRegulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatinBiochemical and cellular characteristics of the 3' -> 5' exonuclease TREX2Structure and Functional Implications of the Human Rad9-Hus1-Rad1 Cell Cycle Checkpoint ComplexCharacterization of DNA damage-stimulated self-interaction of Saccharomyces cerevisiae checkpoint protein Rad17p.Retention of the human Rad9 checkpoint complex in extraction-resistant nuclear complexes after DNA damagePCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibitionReconstitution and molecular analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA damage responsive checkpoint complexA role of the C-terminal region of human Rad9 (hRad9) in nuclear transport of the hRad9 checkpoint complexTLK1B promotes repair of DSBs via its interaction with Rad9 and Asf1.Fission yeast Rad17 associates with chromatin in response to aberrant genomic structuresStructure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes.Mouse Rad1 deletion enhances susceptibility for skin tumor developmentATM-dependent phosphorylation of human Rad9 is required for ionizing radiation-induced checkpoint activation.DNA replication and damage checkpoints and meiotic cell cycle controls in the fission and budding yeasts.Structure-function analysis of fission yeast Hus1-Rad1-Rad9 checkpoint complexInactivation of mouse Hus1 results in genomic instability and impaired responses to genotoxic stressDNA damage checkpoint control in cells exposed to ionizing radiation.XRad17 is required for the activation of XChk1 but not XCds1 during checkpoint signaling in Xenopus.The role of DNA exonucleases in protecting genome stability and their impact on ageing.Targeted deletion of mouse Rad1 leads to deficient cellular DNA damage responses.Characterization of Schizosaccharomyces pombe Hus1: a PCNA-related protein that associates with Rad1 and Rad9Mutant alleles of Schizosaccharomyces pombe rad9(+) alter hydroxyurea resistance, radioresistance and checkpoint control.Mitotic DNA damage and replication checkpoints in yeast.Deletion of mouse rad9 causes abnormal cellular responses to DNA damage, genomic instability, and embryonic lethalityThe Tousled-Like Kinases as Guardians of Genome IntegrityComparative genomic analysis of novel conserved peptide upstream open reading frames in Drosophila melanogaster and other dipteran speciesColocalization of human Rad17 and PCNA in late S phase of the cell cycle upon replication block.
P2860
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P2860
A human homologue of the Schizosaccharomyces pombe rad1+ checkpoint gene encodes an exonuclease
description
1998 nî lūn-bûn
@nan
1998 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
A human homologue of the Schiz ...... nt gene encodes an exonuclease
@ast
A human homologue of the Schiz ...... nt gene encodes an exonuclease
@en
A human homologue of the Schiz ...... nt gene encodes an exonuclease
@en-gb
A human homologue of the Schiz ...... nt gene encodes an exonuclease
@nl
type
label
A human homologue of the Schiz ...... nt gene encodes an exonuclease
@ast
A human homologue of the Schiz ...... nt gene encodes an exonuclease
@en
A human homologue of the Schiz ...... nt gene encodes an exonuclease
@en-gb
A human homologue of the Schiz ...... nt gene encodes an exonuclease
@nl
prefLabel
A human homologue of the Schiz ...... nt gene encodes an exonuclease
@ast
A human homologue of the Schiz ...... nt gene encodes an exonuclease
@en
A human homologue of the Schiz ...... nt gene encodes an exonuclease
@en-gb
A human homologue of the Schiz ...... nt gene encodes an exonuclease
@nl
P2093
P2860
P356
P1476
A human homologue of the Schiz ...... nt gene encodes an exonuclease
@en
P2093
A E Parker
I Oostveen
I Van de Weyer
P Verhasselt
W H Luyten
P2860
P304
P356
10.1074/JBC.273.29.18332
P407
P577
1998-07-17T00:00:00Z