S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenance
about
Modifiers and Readers of DNA Modifications and Their Impact on Genome Structure, Expression, and Stability in DiseasePost-transcriptional gene silencing, transcriptional gene silencing and human immunodeficiency virusNIRF/UHRF2 occupies a central position in the cell cycle network and allows coupling with the epigenetic landscapeStructural Insight into Coordinated Recognition of Trimethylated Histone H3 Lysine 9 (H3K9me3) by the Plant Homeodomain (PHD) and Tandem Tudor Domain (TTD) of UHRF1 (Ubiquitin-like, Containing PHD and RING Finger Domains, 1) ProteinEpigenetic regulation of autophagy by the methyltransferase G9aGreen tea polyphenol epigallocatechin 3-gallate, contributes to the degradation of DNMT3A and HDAC3 in HCT 116 human colon cancer cellsDissecting the precise role of H3K9 methylation in crosstalk with DNA maintenance methylation in mammals.Histone-binding domains: strategies for discovery and characterization.Understanding the relationship between DNA methylation and histone lysine methylation.Non-germ Line Restoration of Genomic Imprinting for a Small Subset of Imprinted Genes in Ubiquitin-like PHD and RING Finger Domain-Containing 1 (Uhrf1) Null Mouse Embryonic Stem CellsNovel Function of Lysine Methyltransferase G9a in the Regulation of Sox2 Protein StabilityA Tox21 Approach to Altered Epigenetic Landscapes: Assessing Epigenetic Toxicity Pathways Leading to Altered Gene Expression and Oncogenic Transformation In VitroA novel histone H4 arginine 3 methylation-sensitive histone H4 binding activity and transcriptional regulatory function for signal recognition particle subunits SRP68 and SRP72.UHRF2, a ubiquitin E3 ligase, acts as a small ubiquitin-like modifier E3 ligase for zinc finger protein 131.Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition.Negative regulation of DNMT3A de novo DNA methylation by frequently overexpressed UHRF family proteins as a mechanism for widespread DNA hypomethylation in cancer.Zinc Finger Protein 618 Regulates the Function of UHRF2 (Ubiquitin-like with PHD and Ring Finger Domains 2) as a Specific 5-Hydroxymethylcytosine ReaderConcerted changes in transcriptional regulation of genes involved in DNA methylation, demethylation, and folate-mediated one-carbon metabolism pathways in the NCI-60 cancer cell line panel in response to cancer drug treatmentMultidimensional Proteomics Reveals a Role of UHRF2 in the Regulation of Epithelial-Mesenchymal Transition (EMT).E2F1 coregulates cell cycle genes and chromatin components during the transition of oligodendrocyte progenitors from proliferation to differentiation.The interplay between the lysine demethylase KDM1A and DNA methyltransferases in cancer cells is cell cycle dependent.Epidermal stem cells and their epigenetic regulation.5-hydroxymethylcytosine profiling as an indicator of cellular state.Interpreting the language of histone and DNA modifications.Centromeric chromatin and its dynamics in plants.The 5-Hydroxymethylcytosine (5hmC) Reader UHRF2 Is Required for Normal Levels of 5hmC in Mouse Adult Brain and Spatial Learning and Memory.DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitinationIdentification of protein complexes that bind to histone H3 combinatorial modifications using super-SILAC and weighted correlation network analysis.Proteins That Read DNA Methylation.The nuclear protein UHRF2 is a direct target of the transcription factor E2F1 in the induction of apoptosisUHRF2 decreases H3K9ac expression by interacting with it through the PHD and SRA/YDG domain in HepG2 hepatocellular carcinoma cells.H3K4 Methyltransferase Set1a Is A Key Oct4 Coactivator Essential for Generation of Oct4 Positive Inner Cell Mass.Loss of UHRF2 expression is associated with human neoplasia, promoter hypermethylation, decreased 5-hydroxymethylcytosine, and high proliferative activity.Upregulation of P53 promoted G1 arrest and apoptosis in human umbilical cord vein endothelial cells from preeclampsia.Overexpression of UHRF2 in intrahepatic cholangiocarcinoma and its clinical significance.Interaction of the epigenetic integrator UHRF1 with the MYST domain of TIP60 inside the cell.UHRF2 regulates local 5-methylcytosine and suppresses spontaneous seizures.UHRF1:Chromatin binds DNMT1Novel method for DNA methylation analysis using high-performance liquid chromatography and its clinical application.Comparative biochemical analysis of UHRF proteins reveals molecular mechanisms that uncouple UHRF2 from DNA methylation maintenance.
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P2860
S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenance
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
S phase-dependent interaction ...... in DNA methylation maintenance
@ast
S phase-dependent interaction ...... in DNA methylation maintenance
@en
type
label
S phase-dependent interaction ...... in DNA methylation maintenance
@ast
S phase-dependent interaction ...... in DNA methylation maintenance
@en
prefLabel
S phase-dependent interaction ...... in DNA methylation maintenance
@ast
S phase-dependent interaction ...... in DNA methylation maintenance
@en
P2093
P2860
P356
P1433
P1476
S phase-dependent interaction ...... in DNA methylation maintenance
@en
P2093
Jiemin Wong
Jiqin Zhang
Qinqin Gao
Weicheng Wu
Xiaoli Liu
Yuanhui Jia
P2860
P2888
P304
P356
10.1038/CR.2011.176
P577
2011-11-08T00:00:00Z