NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein
about
NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressorCritical role of the ubiquitin ligase activity of UHRF1, a nuclear RING finger protein, in tumor cell growth.NIRF/UHRF2 occupies a central position in the cell cycle network and allows coupling with the epigenetic landscapeORTH/VIM proteins that regulate DNA methylation are functional ubiquitin E3 ligases.S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenanceUHRF2, a ubiquitin E3 ligase, acts as a small ubiquitin-like modifier E3 ligase for zinc finger protein 131.Negative regulation of DNMT3A de novo DNA methylation by frequently overexpressed UHRF family proteins as a mechanism for widespread DNA hypomethylation in cancer.Multidimensional Proteomics Reveals a Role of UHRF2 in the Regulation of Epithelial-Mesenchymal Transition (EMT).Intranuclear degradation of polyglutamine aggregates by the ubiquitin-proteasome system.E3 ligase UHRF2 stabilizes the acetyltransferase TIP60 and regulates H3K9ac and H3K14ac via RING finger domain.The Roles of the Methyl-CpG Binding Proteins in Cancer.The 5-Hydroxymethylcytosine (5hmC) Reader UHRF2 Is Required for Normal Levels of 5hmC in Mouse Adult Brain and Spatial Learning and Memory.The nuclear protein UHRF2 is a direct target of the transcription factor E2F1 in the induction of apoptosisNIRF, a novel ubiquitin ligase, interacts with hepatitis B virus core protein and promotes its degradation.Overexpression of UHRF2 in intrahepatic cholangiocarcinoma and its clinical significance.Uhrf2 deletion impairs the formation of hippocampus-dependent memory by changing the structure of the dentate gyrus.Comparative biochemical analysis of UHRF proteins reveals molecular mechanisms that uncouple UHRF2 from DNA methylation maintenance.PEST-containing nuclear protein mediates the proliferation, migration, and invasion of human neuroblastoma cells through MAPK and PI3K/AKT/mTOR signaling pathways.
P2860
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P2860
NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
NIRF is a ubiquitin ligase tha ...... EST-containing nuclear protein
@ast
NIRF is a ubiquitin ligase tha ...... EST-containing nuclear protein
@en
NIRF is a ubiquitin ligase tha ...... EST-containing nuclear protein
@en-gb
NIRF is a ubiquitin ligase tha ...... EST-containing nuclear protein
@nl
type
label
NIRF is a ubiquitin ligase tha ...... EST-containing nuclear protein
@ast
NIRF is a ubiquitin ligase tha ...... EST-containing nuclear protein
@en
NIRF is a ubiquitin ligase tha ...... EST-containing nuclear protein
@en-gb
NIRF is a ubiquitin ligase tha ...... EST-containing nuclear protein
@nl
prefLabel
NIRF is a ubiquitin ligase tha ...... EST-containing nuclear protein
@ast
NIRF is a ubiquitin ligase tha ...... EST-containing nuclear protein
@en
NIRF is a ubiquitin ligase tha ...... EST-containing nuclear protein
@en-gb
NIRF is a ubiquitin ligase tha ...... EST-containing nuclear protein
@nl
P2093
P2860
P921
P3181
P1433
P1476
NIRF is a ubiquitin ligase tha ...... EST-containing nuclear protein
@en
P2093
Hideo Kochi
Hiroaki Hata
Tsutomu Mori
Yuanyuan Li
P2860
P304
P3181
P356
10.1016/S0014-5793(03)01495-9
P407
P577
2004-01-16T00:00:00Z