Small molecules, big targets: drug discovery faces the protein-protein interaction challenge. - Test2 - elhamkhani - TriplyDB

Small molecules, big targets: drug discovery faces the protein-protein interaction challenge.

Small molecules, big targets: drug discovery faces the protein-protein interaction challenge.

http://www.wikidata.org/entity/Q35981250

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dMM-PBSA: A New HADDOCK Scoring Function for Protein-Peptide Docking De Novo Modular Development of a Foldameric Protein-Protein Interaction Inhibitor for Separate Hot Spots: A Dynamic Covalent Assembly Approach.Neighbours of cancer-related proteins have key influence on pathogenesis and could increase the drug target space for anticancer therapies Screening-based approaches to identify small molecules that inhibit protein-protein interactions.Rewiring of the inferred protein interactome during blood development studied with the tool PPICompare.Exploring Non-obvious Hydrophobic Binding Pockets on Protein Surfaces: Increasing Affinities in Peptide-Protein Interactions.What is the future for fragment-based drug discovery?Structure-Guided Design of Peptides as Tools to Probe the Protein-Protein Interaction between Cullin-2 and Elongin BC Substrate Adaptor in Cullin RING E3 Ubiquitin Ligases The impact of structural biology in medicine illustrated with four case studies.Flexibility is important for inhibition of the MDM2/p53 protein-protein interaction by cyclic β-hairpins.Latest Advances Towards Ras Inhibition: A Medicinal Chemistry Perspective.Polymerases of paramyxoviruses and pneumoviruses.Chiral Sulfoxide-Induced Single Turn Peptide α-Helicity.Bioactive Natural Product and Superacid Chemistry for Lead Compound Identification: A Case Study of Selective hCA III and L-Type Ca2+ Current Inhibitors for Hypotensive Agent Discovery.Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a Inhibition of the Ras/Raf interaction and repression of renal cancer xenografts in vivo by an enantiomeric iridium(iii) metal-based compound.Identification and characterization of a novel Sso7d scaffold-based binder against Notch1.Concise Synthesis of Tetrazole Macrocycle Peptide Macrocyclization Inspired by Non-Ribosomal Imine Natural Products.Controlled inhibition of methyltransferases using photoswitchable peptidomimetics: towards an epigenetic regulation of leukemia.Structure-Based Design of Non-natural Macrocyclic Peptides That Inhibit Protein-Protein Interactions.Analysis of Borrelia burgdorferi Proteome and Protein-Protein Interactions.Shortened Penetratin Cell-Penetrating Peptide Is Insufficient for Cytosolic Delivery of a Grb7 Targeting Peptide.Comparative Proteomic Analysis of the Effect of Periplocoside P from Periploca sepium on Brush Border Membrane Vesicles in Midgut Epithelium of Mythimna separata Larvae.WD40 repeat domain proteins: a novel target class?The OncoPPi Portal: an integrative resource to explore and prioritize protein-protein interactions for cancer target discovery.Finding a Silver Bullet in a Stack of Proteins.Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-The Genomic Landscape of the Fungus-Specific SWI/SNF Complex Subunit, Snf6, in Candida albicans.High-Throughput Chemical Probing of Full-Length Protein-Protein Interactions.Toward a Novel Drug To Target the EGF-EGFR Interaction: Design of Metabolically Stable Bicyclic Peptides.In silico ligand-based modeling of hBACE-1 inhibitors.Gankyrin: a novel promising therapeutic target for hepatocellular carcinoma.Small-Molecule Inhibitors of the CD40-CD40L Costimulatory Protein-Protein Interaction.Complete protein-protein association kinetics in atomic detail revealed by molecular dynamics simulations and Markov modelling.Mimicking Intermolecular Interactions of Tight Protein-Protein Complexes for Small-Molecule Antagonists.Directing evolution: the next revolution in drug discovery?Rational design and structure-activity relationship studies of quercetin-amino acid hybrids targeting the anti-apoptotic protein Bcl-xL.WNK Signaling Inhibitors as Potential Antihypertensive Drugs.Perspectives on the discovery of NOTCH2-specific inhibitors.

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Small molecules, big targets: drug discovery faces the protein-protein interaction challenge.

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Nature Reviews Drug Discovery

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Andrew R Bayly

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Chris Abell

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Duncan E Scott

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Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling

Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling

Selective inhibition of BET bromodomains

Histone recognition and large-scale structural analysis of the human bromodomain family

Insights into DNA recombination from the structure of a RAD51-BRCA2 complex

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.

The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored

Systematic analysis of helical protein interfaces reveals targets for synthetic inhibitors

Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

A first-draft human protein-interaction map

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10.1038/NRD.2016.29

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