Delayed commitment to evolutionary fate in antibiotic resistance fitness landscapes.
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Adaptive Landscape by Environment Interactions Dictate Evolutionary Dynamics in Models of Drug ResistanceReverse Chemical Genetics: Comprehensive Fitness Profiling Reveals the Spectrum of Drug Target InteractionsSequence-Specific Targeting of Bacterial Resistance Genes Increases Antibiotic EfficacyDifferent Evolutionary Paths to Complexity for Small and Large Populations of Digital OrganismsEnzyme Efficiency but Not Thermostability Drives Cefotaxime Resistance Evolution in TEM-1 β-Lactamase.Stability-Mediated Epistasis Restricts Accessible Mutational Pathways in the Functional Evolution of Avian Hemoglobin.Multidrug evolutionary strategies to reverse antibiotic resistance.Beyond the Hypercube: Evolutionary Accessibility of Fitness Landscapes with Realistic Mutational Networks.High-order epistasis shapes evolutionary trajectories.Biophysical principles predict fitness landscapes of drug resistance.Combinatorial Genetic Modeling of pfcrt-Mediated Drug Resistance Evolution in Plasmodium falciparum.Adaptation in protein fitness landscapes is facilitated by indirect pathsGenonets server-a web server for the construction, analysis and visualization of genotype networks.Genetic variation in adaptability and pleiotropy in budding yeast.Bridging the physical scales in evolutionary biology: from protein sequence space to fitness of organisms and populations.The evolution of antimicrobial peptide resistance in Pseudomonas aeruginosa is shaped by strong epistatic interactions.How mutational epistasis impairs predictability in protein evolution and designUsing cellular fitness to map the structure and function of a major facilitator superfamily effluxer.Sexual recombination and increased mutation rate expedite evolution of Escherichia coli in varied fitness landscapes.Effects of Beneficial Mutations in pykF Gene Vary over Time and across Replicate Populations in a Long-Term Experiment with Bacteria.Rational Design of Novel Allosteric Dihydrofolate Reductase Inhibitors Showing Antibacterial Effects on Drug-Resistant Escherichia coli Escape Variants.Increased substrate affinity in the Escherichia coli L28R dihydrofolate reductase mutant causes trimethoprim resistance.Pathogenic Nocardia cyriacigeorgica and Nocardia nova evolve to resist trimethoprim-sulfamethoxazole by both expected and unexpected pathways.Diminishing-returns epistasis among random beneficial mutations in a multicellular fungus.The Influence of Higher-Order Epistasis on Biological Fitness Landscape Topography.Evolution of complex adaptations in molecular systems.Directed evolution of multiple genomic loci allows the prediction of antibiotic resistance.Phenotypic Switching Can Speed up Microbial Evolution.Competition along trajectories governs adaptation rates towards antimicrobial resistanceMultiplexed deactivated CRISPR-Cas9 gene expression perturbations deter bacterial adaptation by inducing negative epistasisExperimental Design, Population Dynamics, and Diversity in Microbial Experimental EvolutionFunctional trade-offs and environmental variation shaped ancient trajectories in the evolution of dim-light visionEnvironmental pleiotropy and demographic history direct adaptation under antibiotic selectionPairwise and higher-order genetic interactions during the evolution of a tRNA
P2860
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P2860
Delayed commitment to evolutionary fate in antibiotic resistance fitness landscapes.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Delayed commitment to evolutionary fate in antibiotic resistance fitness landscapes.
@ast
Delayed commitment to evolutionary fate in antibiotic resistance fitness landscapes.
@en
type
label
Delayed commitment to evolutionary fate in antibiotic resistance fitness landscapes.
@ast
Delayed commitment to evolutionary fate in antibiotic resistance fitness landscapes.
@en
prefLabel
Delayed commitment to evolutionary fate in antibiotic resistance fitness landscapes.
@ast
Delayed commitment to evolutionary fate in antibiotic resistance fitness landscapes.
@en
P2860
P50
P356
P1476
Delayed commitment to evolutionary fate in antibiotic resistance fitness landscapes.
@en
P2093
Erdal Toprak
Roy Kishony
P2860
P2888
P356
10.1038/NCOMMS8385
P407
P577
2015-06-10T00:00:00Z