Darwinian evolution can follow only very few mutational paths to fitter proteins
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Evidence that adaptation in Drosophila is not limited by mutation at single sitesEpistatic adaptive evolution of human color visionStability-mediated epistasis constrains the evolution of an influenza proteinPredictability of evolutionary trajectories in fitness landscapesLong intervals of stasis punctuated by bursts of positive selection in the seasonal evolution of influenza A virusQuantifying the adaptive potential of an antibiotic resistance enzymeClimbing Mount Probable: Mutation as a Cause of Nonrandomness in EvolutionHistorical contingency and the evolution of a key innovation in an experimental population of Escherichia coliIn the light of directed evolution: pathways of adaptive protein evolutionEpistasis--the essential role of gene interactions in the structure and evolution of genetic systemsFactors shaping the adaptive landscape for arboviruses: implications for the emergence of diseaseConstraints and plasticity in genome and molecular-phenome evolutionThe genetic code constrains yet facilitates Darwinian evolutionExploring protein fitness landscapes by directed evolutionQuantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthasesThe evolutionary origins of beneficial alleles during the repeated adaptation of garter snakes to deadly prey.Crystal structure of an ancient protein: evolution by conformational epistasisEngineering and Evolution of Molecular Chaperones and Protein Disaggregases with Enhanced ActivityReplaying the tape of life in the twenty-first centuryElucidating the molecular architecture of adaptation via evolve and resequence experimentsFitness Landscapes of Functional RNAsEvolutionary determinants of cancerWhat can we learn from fitness landscapes?Spatiotemporal microbial evolution on antibiotic landscapesThe causes of epistasisThe interface of protein structure, protein biophysics, and molecular evolutionThe spectrum of adaptive mutations in experimental evolutionCancer evolution: mathematical models and computational inferenceExperimental approaches to evaluate the contributions of candidate protein-coding mutations to phenotypic evolutionEvolution of drug resistance in tuberculosis: recent progress and implications for diagnosis and therapyEncoding asymmetry of the N-glycosylation motif facilitates glycoprotein evolutionA universal mechanism of extreme events and critical phenomena.Structure-based optimization of cephalothin-analogue boronic acids as β-lactamase inhibitorsAdaptive protein evolution grants organismal fitness by improving catalysis and flexibilityFollowing evolutionary paths to protein-protein interactions with high affinity and selectivityAn epistatic ratchet constrains the direction of glucocorticoid receptor evolutionStructural Bases for Stability–Function Tradeoffs in Antibiotic ResistanceFunctional significance of evolving protein sequence in dihydrofolate reductase from bacteria to humansStructural Basis of a Rationally Rewired Protein-Protein Interface Critical to Bacterial SignalingDoes your gene need a background check? How genetic background impacts the analysis of mutations, genes, and evolution
P2860
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P2860
Darwinian evolution can follow only very few mutational paths to fitter proteins
description
2006 nî lūn-bûn
@nan
2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Darwinian evolution can follow only very few mutational paths to fitter proteins
@ast
Darwinian evolution can follow only very few mutational paths to fitter proteins
@en
type
label
Darwinian evolution can follow only very few mutational paths to fitter proteins
@ast
Darwinian evolution can follow only very few mutational paths to fitter proteins
@en
prefLabel
Darwinian evolution can follow only very few mutational paths to fitter proteins
@ast
Darwinian evolution can follow only very few mutational paths to fitter proteins
@en
P2093
P3181
P356
P1433
P1476
Darwinian evolution can follow only very few mutational paths to fitter proteins
@en
P2093
Delaney NF
Depristo MA
Weinreich DM
P3181
P356
10.1126/SCIENCE.1123539
P407
P577
2006-04-07T00:00:00Z