Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease.
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Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer diseaseNeuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.Nasal vaccination with a proteosome-based adjuvant and glatiramer acetate clears beta-amyloid in a mouse model of Alzheimer diseaseLevetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model.Reversing EphB2 depletion rescues cognitive functions in Alzheimer modelAmyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patientsActive and passive immunotherapy for neurodegenerative disordersImmunotherapy targeting pyroglutamate-3 Aβ: prospects and challengesThe Epidemiological Scale of Alzheimer's DiseaseTargeting the proper amyloid-beta neuronal toxins: a path forward for Alzheimer's disease immunotherapeuticsDifferential contributions of ApoE4 and female sex to BACE1 activity and expression mediate Aβ deposition and learning and memory in mouse models of Alzheimer's diseaseBapineuzumab captures the N-terminus of the Alzheimer's disease amyloid-beta peptide in a helical conformationCrystallization and preliminary X-ray diffraction analysis of the Fab portion of the Alzheimer's disease immunotherapy candidate bapineuzumab complexed with amyloid-βThe antibody aducanumab reduces Aβ plaques in Alzheimer’s diseasebeta-site APP cleaving enzyme mRNA expression in APP transgenic mice: anatomical overlap with transgene expression and static levels with agingIn vitro studies of amyloid beta-protein fibril assembly and toxicity provide clues to the aetiology of Flemish variant (Ala692-->Gly) Alzheimer's diseaseAccumulation of amyloid beta-protein in the low-density membrane domain accurately reflects the extent of beta-amyloid deposition in the brainApoAI deficiency results in marked reductions in plasma cholesterol but no alterations in amyloid-beta pathology in a mouse model of Alzheimer's disease-like cerebral amyloidosisClusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's diseaseSortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependent stimulation of ERK signaling and adult neurogenesisThe Psen1-L166P-knock-in mutation leads to amyloid deposition in human wild-type amyloid precursor protein YAC transgenic mice.Amyloid-beta protofibril levels correlate with spatial learning in Arctic Alzheimer's disease transgenic mice.Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease.Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease.Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network.Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor proteinAlzheimer disease models and human neuropathology: similarities and differencesThe involvement of Cdk5 activator p35 in social isolation-triggered onset of early Alzheimer's disease-related cognitive deficit in the transgenic mice.Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.Alterations in synaptic plasticity coincide with deficits in spatial working memory in presymptomatic 3xTg-AD mice.Presenilin 1 and Presenilin 2 Target γ-Secretase Complexes to Distinct Cellular Compartments.Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides.Quantification of Alzheimer pathology in ageing and dementia: age-related accumulation of amyloid-beta(42) peptide in vascular dementia.Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease.Selective vulnerability of dentate granule cells prior to amyloid deposition in PDAPP mice: digital morphometric analysesBiochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life.Phenotypic analysis of images of zebrafish treated with Alzheimer's gamma-secretase inhibitors.Amyloid and lipids in the pathology of Alzheimer disease.The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons.Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation.
P2860
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P2860
Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Amyloid precursor protein proc ...... se model of Alzheimer disease.
@ast
Amyloid precursor protein proc ...... se model of Alzheimer disease.
@en
type
label
Amyloid precursor protein proc ...... se model of Alzheimer disease.
@ast
Amyloid precursor protein proc ...... se model of Alzheimer disease.
@en
prefLabel
Amyloid precursor protein proc ...... se model of Alzheimer disease.
@ast
Amyloid precursor protein proc ...... se model of Alzheimer disease.
@en
P2093
P2860
P356
P1476
Amyloid precursor protein proc ...... se model of Alzheimer disease.
@en
P2093
Johnson-Wood K
Lieberburg I
McConlogue L
P2860
P304
P356
10.1073/PNAS.94.4.1550
P407
P577
1997-02-01T00:00:00Z