Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene
about
Clinical immunologic approaches for the treatment of Alzheimer's diseaseLysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin SProtein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseasesIslet amyloid in type 2 diabetes, and the toxic oligomer hypothesisBACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor proteinCopper-2 Ingestion, Plus Increased Meat Eating Leading to Increased Copper Absorption, Are Major Factors Behind the Current Epidemic of Alzheimer's Diseaseβ-Amyloid: the key peptide in the pathogenesis of Alzheimer's diseaseHistamine and the striatumAutosomal Dominant Alzheimer Disease: A Unique Resource to Study CSF Biomarker Changes in Preclinical ADCaenorhabditis elegans as a model organism to study APP functionBehavioral assays with mouse models of Alzheimer's disease: practical considerations and guidelines.A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloidDivalent Copper as a Major Triggering Agent in Alzheimer's DiseaseTrafficking and proteolytic processing of APPProcessing of the pre-beta-amyloid protein by cathepsin D is enhanced by a familial Alzheimer's disease mutationCandidate gene for the chromosome 1 familial Alzheimer's disease locusProfiles of amyloid precursor and presenilin 2-like proteins are correlated during development of the mouse hypothalamusMice lacking both presenilin genes exhibit early embryonic patterning defectsGenetic mechanisms of coffee extract protection in a Caenorhabditis elegans model of β-amyloid peptide toxicityA beta oligomers - a decade of discoveryCytoskeletal pathologies of Alzheimer diseaseAge-related increase in amyloid plaque burden is associated with impairment in conditioned fear memory in CRND8 mouse model of amyloidosis.Alzheimer disease models and human neuropathology: similarities and differencesNeurofibrillary pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein.Presenilin-1 C410Y Alzheimer disease plaques contain synaptic proteins.Observation of amyloid precursor protein cleavage and A beta generation in living cells by using multiphoton laser scanning microscopy.Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants.Aberrant amyloid precursor protein (APP) processing in hereditary forms of Alzheimer disease caused by APP familial Alzheimer disease mutations can be rescued by mutations in the APP GxxxG motif.Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes.Genetic risk factors in Alzheimer's diseaseAbsence of the amyloid precursor protein gene mutation (APP717: Val->Ile) in 85 cases of early onset Alzheimer's disease.RFLP analysis for APP 717 mutations associated with Alzheimer's diseaseGenetic transmission of Alzheimer's disease among families in a Dutch population based studyConfirmation of association between the e4 allele of apolipoprotein E and Alzheimer's diseaseNo founder effect in three novel Alzheimer's disease families with APP 717 Val-->Ile mutation. Clerget-darpoux. French Alzheimer's Disease Study Group.The tRNA(Gln) 4336 mitochondrial DNA variant is not a high penetrance mutation which predisposes to dementia before the age of 75 years.Alzheimer's disease and the amyloid beta protein: What is the role of amyloid?Clinical genetics of Alzheimer's diseasePresenilins and the gamma-secretase: still a complex problem.Hereditary cerebral hemorrhage with amyloidosis--Dutch type (HCHWA-D): a review of the variety in phenotypic expression.
P2860
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P2860
Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene
description
1991 nî lūn-bûn
@nan
1991 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
name
Early-onset Alzheimer's diseas ...... amyloid precursor protein gene
@ast
Early-onset Alzheimer's diseas ...... amyloid precursor protein gene
@en
Early-onset Alzheimer's diseas ...... amyloid precursor protein gene
@nl
type
label
Early-onset Alzheimer's diseas ...... amyloid precursor protein gene
@ast
Early-onset Alzheimer's diseas ...... amyloid precursor protein gene
@en
Early-onset Alzheimer's diseas ...... amyloid precursor protein gene
@nl
prefLabel
Early-onset Alzheimer's diseas ...... amyloid precursor protein gene
@ast
Early-onset Alzheimer's diseas ...... amyloid precursor protein gene
@en
Early-onset Alzheimer's diseas ...... amyloid precursor protein gene
@nl
P2093
P356
P1433
P1476
Early-onset Alzheimer's diseas ...... amyloid precursor protein gene
@en
P2093
F Crawford
M C Chartier-Harlin
P2888
P356
10.1038/353844A0
P407
P577
1991-10-31T00:00:00Z
P6179
1017416134