Lentiviral-mediated RNAi inhibition of Sbds in murine hematopoietic progenitors impairs their hematopoietic potential
about
SBDS expression and localization at the mitotic spindle in human myeloid progenitorsMitotic spindle destabilization and genomic instability in Shwachman-Diamond syndromeMinireview: complexity of hematopoietic stem cell regulation in the bone marrow microenvironmentKnockdown of Hspa9, a del(5q31.2) gene, results in a decrease in hematopoietic progenitors in miceShwachman-Bodian Diamond syndrome is a multi-functional protein implicated in cellular stress responses.SBDS protein expression patterns in the bone marrow.Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia.Non-Diamond Blackfan anemia disorders of ribosome function: Shwachman Diamond syndrome and 5q- syndromeVinculin is indispensable for repopulation by hematopoietic stem cells, independent of integrin function.Marrow failure: a window into ribosome biologyDeficiency of the ribosome biogenesis gene Sbds in hematopoietic stem and progenitor cells causes neutropenia in mice by attenuating lineage progression in myelocytes.SBDS-Deficient Cells Have an Altered Homeostatic Equilibrium due to Translational Inefficiency Which Explains their Reduced Fitness and Provides a Logical Framework for Intervention.Clinical spectrum and molecular pathophysiology of Shwachman-Diamond syndromeImpaired ribosomal subunit association in Shwachman-Diamond syndrome.Telomere maintenance and human bone marrow failurePathophysiology and management of inherited bone marrow failure syndromes.Shwachman-Diamond syndrome: a review of the clinical presentation, molecular pathogenesis, diagnosis, and treatment.Do ribosomopathies explain some cases of common variable immunodeficiency?The microenvironment in myelodysplastic syndromes: niche-mediated disease initiation and progression.Shwachman-Bodian-Diamond syndrome (SBDS) protein deficiency impairs translation re-initiation from C/EBPα and C/EBPβ mRNAsImpaired growth, hematopoietic colony formation, and ribosome maturation in human cells depleted of Shwachman-Diamond syndrome protein SBDS.A novel mouse model provides insights into the neutropenia associated with the ribosomopathy Shwachman-Diamond syndrome.Mislocalization or low expression of mutated Shwachman-Bodian-Diamond syndrome protein.Sixth International Congress on Shwachman-Diamond syndrome: from patients to genes and back.
P2860
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P2860
Lentiviral-mediated RNAi inhibition of Sbds in murine hematopoietic progenitors impairs their hematopoietic potential
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Lentiviral-mediated RNAi inhib ...... their hematopoietic potential
@ast
Lentiviral-mediated RNAi inhib ...... their hematopoietic potential
@en
type
label
Lentiviral-mediated RNAi inhib ...... their hematopoietic potential
@ast
Lentiviral-mediated RNAi inhib ...... their hematopoietic potential
@en
prefLabel
Lentiviral-mediated RNAi inhib ...... their hematopoietic potential
@ast
Lentiviral-mediated RNAi inhib ...... their hematopoietic potential
@en
P2093
P2860
P1433
P1476
Lentiviral-mediated RNAi inhib ...... their hematopoietic potential
@en
P2093
Alyssa D Gregory
Amy S Rawls
Daniel C Link
Jill R Woloszynek
P2860
P304
P356
10.1182/BLOOD-2006-03-007112
P407
P577
2007-07-17T00:00:00Z