Activation of the orexin 1 receptor is a critical component of CO2-mediated anxiety and hypertension but not bradycardia.
about
OX1 and OX2 orexin/hypocretin receptor pharmacogeneticsAn animal model of panic vulnerability with chronic disinhibition of the dorsomedial/perifornical hypothalamusEtiology, triggers and neurochemical circuits associated with unexpected, expected, and laboratory-induced panic attacksEnhanced non-eupneic breathing following hypoxic, hypercapnic or hypoxic-hypercapnic gas challenges in conscious mice.Neuroendocrine and sympathetic responses to an orexin receptor antagonist, SB-649868, and alprazolam following insulin-induced hypoglycemia in humansOrexin/hypocretin system modulates amygdala-dependent threat learning through the locus coeruleus.Orexin 1 receptors are a novel target to modulate panic responses and the panic brain network.CO2 exposure as translational cross-species experimental model for panicEvaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation.To ingest or rest? Specialized roles of lateral hypothalamic area neurons in coordinating energy balance.Anxiolytic function of the orexin 2/hypocretin A receptor in the basolateral amygdalaAcid-base dysregulation and chemosensory mechanisms in panic disorder: a translational update5-HT2A receptor activation is necessary for CO2-induced arousal.Orexin, stress, and anxiety/panic states.Differential actions of orexin receptors in brainstem cholinergic and monoaminergic neurons revealed by receptor knockouts: implications for orexinergic signaling in arousal and narcolepsy.Orexin, orexin receptor antagonists and central cardiovascular control.Biological markers for anxiety disorders, OCD and PTSD: A consensus statement. Part II: Neurochemistry, neurophysiology and neurocognition.Role of orexin in the pathophysiology of depression: potential for pharmacological intervention.The hypocretin/orexin system: an increasingly important role in neuropsychiatry.Novel investigational therapeutics for panic disorder.Differential behavioral sensitivity to carbon dioxide (CO2) inhalation in rats.Pharmacotherapy in Generalized Anxiety Disorder: Novel Experimental Medicine Models and Emerging Drug Targets.Evaluation of Low versus High Volume per Minute Displacement CO₂ Methods of Euthanasia in the Induction and Duration of Panic-Associated Behavior and Physiology.Anxiogenic CO2 stimulus elicits exacerbated hot flash-like responses in a rat menopause model and hot flashes in postmenopausal women.OREXIN 1 AND 2 RECEPTOR INVOLVEMENT IN CO2 -INDUCED PANIC-ASSOCIATED BEHAVIOR AND AUTONOMIC RESPONSES.Acute Heat Stress Alters the Expression of Orexin System in Quail Muscle.Dorsal raphe serotonin neurons mediate CO2- induced arousal from sleep.Neonatal maternal separation opposes the facilitatory effect of castration on the respiratory response to hypercapnia of the adult male rat: Evidence for the involvement of the medial amygdala.Orexin neuropeptides contribute to the development and persistence of generalized avoidance behavior in the rat.The brain orexin system and almorexant in fear-conditioned startle reactions in the rat.Assessing Panic: Bridging the Gap Between Fundamental Mechanisms and Daily Life Experience
P2860
Q26865384-B1F548BD-605D-47B5-A89C-5E09ADE08EA6Q27008085-4B810C61-814A-4D21-BA2A-B306947BF5DBQ27026213-D0F0DBB8-975C-4BB3-BADF-8AD21AB20942Q30366078-8A6F3990-05B6-4DF2-83A6-985BFFBA8DB8Q30431029-2EEAAD11-013B-44BE-93D2-FFC391DCB250Q30445331-075BDABC-34A4-4A12-BA7F-E51EA924DA33Q30446233-1958E751-70D6-4195-9BA3-610236EE2104Q30818458-2D498AD0-5742-4BFD-B880-368CBE8CBB4DQ33780634-8D781CF6-A233-4D32-8458-71A2CD5BAAF7Q34668388-0788AB4F-2408-4BC7-AEB8-C69F0830E51DQ35183155-68B005C2-1DAA-446C-821E-29CDE58F49D4Q35753229-0A3FF747-3AB3-417C-9916-8E2485FBC398Q35867477-F2293058-A09B-474B-8A26-4F72482C1AB0Q36880278-7AEEB64F-4E3F-41E0-B2C7-6D795F9151CAQ37406178-3E4FF9DF-A274-42F8-A530-3C00FF96A395Q37417966-413E8685-2F5E-4175-B022-99DDB14BA32CQ37686937-0D73B070-AB49-4089-9F2F-53C05FB7A350Q38105280-A1A1FA9E-9E87-44EA-BAC4-641F9A853A83Q38231949-5898E88D-E619-4690-A57D-0D98C67BD526Q38300166-813E73FF-DF8B-4583-AFB1-C4FAEB86C050Q39021325-3ACB5B13-ABDC-4721-A07B-CE8140671693Q39183229-0C993874-29B9-4819-83A0-DDB7F2F090E1Q41210056-4ED16193-D600-4714-BE56-CF267CB893F5Q42676948-2A05026D-2C77-4F64-A444-AC3BD12EFB91Q43065862-7113B59A-DD22-44E2-969C-8AA976E39645Q47194591-E29599F8-841E-4C68-A2A1-DE8150AC28E2Q47550999-E4C6525A-5256-4DBF-B57F-0A0613F28724Q47600668-CD8CEE40-B5A0-42A9-B1DE-456CD23DF0CDQ47798902-D0B204D2-D0DF-4538-A243-07FD7E00E9CDQ48509094-712F8117-41E0-4126-ACD2-4DC756729594Q59127656-CD3367C9-2E24-43FD-A59E-74E51CFDEE7B
P2860
Activation of the orexin 1 receptor is a critical component of CO2-mediated anxiety and hypertension but not bradycardia.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Activation of the orexin 1 rec ...... ertension but not bradycardia.
@ast
Activation of the orexin 1 rec ...... ertension but not bradycardia.
@en
type
label
Activation of the orexin 1 rec ...... ertension but not bradycardia.
@ast
Activation of the orexin 1 rec ...... ertension but not bradycardia.
@en
prefLabel
Activation of the orexin 1 rec ...... ertension but not bradycardia.
@ast
Activation of the orexin 1 rec ...... ertension but not bradycardia.
@en
P2093
P2860
P50
P356
P1476
Activation of the orexin 1 rec ...... pertension but not bradycardia
@en
P2093
Anantha Shekhar
Christopher A Lowry
Stephanie D Fitz
P2860
P2888
P304
P356
10.1038/NPP.2012.38
P407
P577
2012-03-28T00:00:00Z