A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity
about
Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in manKey Challenges and Opportunities Associated with the Use of In Vitro Models to Detect Human DILI: Integrated Risk Assessment and Mitigation PlansThe Importance of Patient-Specific Factors for Hepatic Drug Response and ToxicityTranscriptional, Functional, and Mechanistic Comparisons of Stem Cell-Derived Hepatocytes, HepaRG Cells, and Three-Dimensional Human Hepatocyte Spheroids as Predictive In Vitro Systems for Drug-Induced Liver Injury.Test systems in drug discovery for hazard identification and risk assessment of human drug-induced liver injury.Endogenous and xenobiotic metabolic stability of primary human hepatocytes in long-term 3D spheroid cultures revealed by a combination of targeted and untargeted metabolomics.Hepatocyte CYP2B6 Can Be Expressed in Cell Culture Systems by Exerting Physiological Levels of Shear: Implications for ADME TestingInnovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms.Comparison of hepatic 2D sandwich cultures and 3D spheroids for long-term toxicity applications: A multi-center study.Glutathione S-Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells.Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds.Prediction of Drug-Induced Hepatotoxicity Using Long-Term Stable Primary Hepatic 3D Spheroid Cultures in Chemically Defined Conditions.Building predictive in vitro pulmonary toxicity assays using high-throughput imaging and artificial intelligence.
P2860
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P2860
A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
A multicenter assessment of si ...... iction of acute hepatotoxicity
@ast
A multicenter assessment of si ...... iction of acute hepatotoxicity
@en
type
label
A multicenter assessment of si ...... iction of acute hepatotoxicity
@ast
A multicenter assessment of si ...... iction of acute hepatotoxicity
@en
prefLabel
A multicenter assessment of si ...... iction of acute hepatotoxicity
@ast
A multicenter assessment of si ...... iction of acute hepatotoxicity
@en
P2093
P2860
P1476
A multicenter assessment of si ...... iction of acute hepatotoxicity
@en
P2093
B Kevin Park
Cerys A Lovatt
Chris E Goldring
Christopher A Schofield
Delphine Hoët
Eliane Alexandre
Esther Johann
Gilles Labbe
Helga H J Gerets
Hélène Aerts
P2860
P2888
P304
P356
10.1007/S00204-016-1745-4
P577
2016-06-25T00:00:00Z