Bidirectional Effect of Pregnenolone Sulfate on GluN1/GluN2A N-Methyl-D-Aspartate Receptor Gating Depending on Extracellular Calcium and Intracellular Milieu

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A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors.Mechanism and properties of positive allosteric modulation of N-methyl-d-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives.

P2860

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P2860

Bidirectional Effect of Pregnenolone Sulfate on GluN1/GluN2A N-Methyl-D-Aspartate Receptor Gating Depending on Extracellular Calcium and Intracellular Milieu

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2015 nî lūn-bûn

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Bidirectional Effect of Pregne ...... lcium and Intracellular Milieu

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Bidirectional Effect of Pregne ...... lcium and Intracellular Milieu

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Bidirectional Effect of Pregne ...... lcium and Intracellular Milieu

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Bidirectional Effect of Pregne ...... lcium and Intracellular Milieu

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Daniel T Monaghan

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Divyan A Chopra

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Shashank M Dravid

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P2860

Crystal structure of a heterotetrameric NMDA receptor ion channel

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Pregnenolone sulfate normalizes schizophrenia-like behaviors in dopamine transporter knockout mice through the AKT/GSK3β pathway.

Estimating single-channel kinetic parameters from idealized patch-clamp data containing missed events.

A steroid modulatory domain on NR2B controls N-methyl-D-aspartate receptor proton sensitivity

Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor.

Inhibition of the NMDA response by pregnenolone sulphate reveals subtype selective modulation of NMDA receptors by sulphated steroids.

Local constraints in either the GluN1 or GluN2 subunit equally impair NMDA receptor pore opening.

Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators

Molecular pharmacology of human NMDA receptors

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scholarly article

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10.1124/MOL.115.100396

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Bidirectional Effect of Pregnenolone Sulfate on GluN1/GluN2A N-Methyl-D-Aspartate Receptor Gating Depending on Extracellular Calcium and Intracellular Milieu

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P2860

P2860

Bidirectional Effect of Pregnenolone Sulfate on GluN1/GluN2A N-Methyl-D-Aspartate Receptor Gating Depending on Extracellular Calcium and Intracellular Milieu

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P1433

P1476

P2093

P2860

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P433

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P2860

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P433

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