A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins.
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Mechanisms of Origin, Phenotypic Effects and Diagnostic Implications of Complex Chromosome RearrangementsMIRO GTPases in Mitochondrial Transport, Homeostasis and PathologyDISC1 complexes with TRAK1 and Miro1 to modulate anterograde axonal mitochondrial traffickingInhibition of protein translation by the DISC1-Boymaw fusion gene from a Scottish family with major psychiatric disorders.708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits.Deciphering the pathogenic consequences of chromosomal aberrations in human genetic disease.Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1Gene Fusion due to Chromosome Misconnection May Seriously Affect Your Health.Induction of site-specific chromosomal translocations in embryonic stem cells by CRISPR/Cas9.DISC1 genetics, biology and psychiatric illnessSUMOylation of DISC1: a potential role in neural progenitor proliferation in the developing cortex.Balanced translocation linked to psychiatric disorder, glutamate, and cortical structure/function.Formation of chimeric genes by copy-number variation as a mutational mechanism in schizophrenia.Aerobic glycolysis in the primate brain: reconsidering the implications for growth and maintenance.Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system.Disrupted in schizophrenia 1 (DISC1) is a constituent of the mammalian mitochondrial contact site and cristae organizing system (MICOS) complex, and is essential for oxidative phosphorylation.CRISPR/Cas9 genome editing in human pluripotent stem cells: Harnessing human genetics in a dish.Neuregulin-1 Regulates Cortical Inhibitory Neuron Dendrite and Synapse Growth through DISC1.Boymaw, overexpressed in brains with major psychiatric disorders, may encode a small protein to inhibit mitochondrial function and protein translation.DISC1 causes associative memory and neurodevelopmental defects in fruit flies.Human cellular differences in cAMP--CREB signaling correlate with light-dependent melatonin suppression and bipolar disorder.Analysis of the DISC1 translocation partner (11q14.3) in genetic risk of schizophrenia.DISC1 as a genetic risk factor for schizophrenia and related major mental illness: response to Sullivan.DISC1-dependent Regulation of Mitochondrial Dynamics Controls the Morphogenesis of Complex Neuronal Dendrites.Phenotypic characterization of C57BL/6J mice carrying the Disc1 gene from the 129S6/SvEv strain.Analysis of Shared Haplotypes amongst Palauans Maps Loci for Psychotic Disorders to 4q28 and 5q23-q31.Disrupted-in-Schizophrenia-1 (DISC1) protein disturbs neural function in multiple disease-risk pathways.DISC1 regulates lactate metabolism in astrocytes: implications for psychiatric disorders.
P2860
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P2860
A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins.
description
2012 nî lūn-bûn
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2012年の論文
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2012年論文
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2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
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2012年论文
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name
A t(1;11) translocation linked ...... erious mitochondrial proteins.
@ast
A t(1;11) translocation linked ...... erious mitochondrial proteins.
@en
type
label
A t(1;11) translocation linked ...... erious mitochondrial proteins.
@ast
A t(1;11) translocation linked ...... erious mitochondrial proteins.
@en
prefLabel
A t(1;11) translocation linked ...... erious mitochondrial proteins.
@ast
A t(1;11) translocation linked ...... erious mitochondrial proteins.
@en
P2093
P2860
P50
P356
P1476
A t(1;11) translocation linked ...... erious mitochondrial proteins.
@en
P2093
Douglas H Blackwood
Elise L V Malavasi
Elizabeth A Blackburn
Fumiaki Ogawa
Gareth J Briggs
J Kirsty Millar
Janice Bramham
Jennifer E Eykelenboom
Martin A Wear
Mary P Malloy
P2860
P304
P356
10.1093/HMG/DDS169
P577
2012-04-30T00:00:00Z