about
DISC1-binding proteins in neural development, signalling and schizophreniaDISC1: Structure, Function, and Therapeutic Potential for Major Mental IllnessDISC1, PDE4B, and NDE1 at the centrosome and synapseAggregation of the protein TRIOBP-1 and its potential relevance to schizophrenia.Recent and recurrent selective sweeps of the antiviral RNAi gene Argonaute-2 in three species of DrosophilaA t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins.The mitosis and neurodevelopment proteins NDE1 and NDEL1 form dimers, tetramers, and polymers with a folded back structure in solution.Proteomic, genomic and translational approaches identify CRMP1 for a role in schizophrenia and its underlying traits.NDE1 and NDEL1: twin neurodevelopmental proteins with similar 'nature' but different 'nurture'.An unpredicted aggregation-critical region of the actin-polymerizing protein TRIOBP-1/Tara, determined by elucidation of its domain structure.Cloning of the promoter of NDE1, a gene implicated in psychiatric and neurodevelopmental disorders through copy number variation.NDE1 and NDEL1 from genes to (mal)functions: parallel but distinct roles impacting on neurodevelopmental disorders and psychiatric illness.PKA phosphorylation of NDE1 is DISC1/PDE4 dependent and modulates its interaction with LIS1 and NDEL1NDE1 and NDEL1: multimerisation, alternate splicing and DISC1 interaction.The NDE1 genomic locus can affect treatment of psychiatric illness through gene expression changes related to microRNA-484.Biophysical insights from a single chain camelid antibody directed against the Disrupted-in-Schizophrenia 1 protein.Disrupted in Schizophrenia 1 regulates the processing of reelin in the perinatal cortex.Loss of Reelin protects mice against arterial thrombosis by impairing integrin activation and thrombus formation under high shear conditions.A structural organization for the Disrupted in Schizophrenia 1 protein, identified by high-throughput screening, reveals distinctly folded regions, which are bisected by mental illness-related mutations.Protein misassembly and aggregation as potential convergence points for non-genetic causes of chronic mental illness
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description
hulumtues
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researcher
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հետազոտող
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name
Nicholas J. Bradshaw
@ast
Nicholas J. Bradshaw
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Nicholas J. Bradshaw
@es
Nicholas J. Bradshaw
@nl
Nicholas J. Bradshaw
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type
label
Nicholas J. Bradshaw
@ast
Nicholas J. Bradshaw
@en
Nicholas J. Bradshaw
@es
Nicholas J. Bradshaw
@nl
Nicholas J. Bradshaw
@sl
prefLabel
Nicholas J. Bradshaw
@ast
Nicholas J. Bradshaw
@en
Nicholas J. Bradshaw
@es
Nicholas J. Bradshaw
@nl
Nicholas J. Bradshaw
@sl
P1053
A-5625-2009
P106
P1153
7003314018
P21
P2798
P31
P3829
P496
0000-0001-5581-8828