Replication fork stability confers chemoresistance in BRCA-deficient cells
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Understanding specific functions of PARP-2: new lessons for cancer therapyRecent Developments Using Small Molecules to Target RAD51: How to Best Modulate RAD51 for Anticancer Therapy?Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis.Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies.Erratum: Replication fork stability confers chemoresistance in BRCA-deficient cells.The MMS22L-TONSL heterodimer directly promotes RAD51-dependent recombination upon replication stress.Reverse the Resistance to PARP Inhibitors.Abro1 maintains genome stability and limits replication stress by protecting replication fork stability.Sunitinib induces genomic instability of renal carcinoma cells through affecting the interaction of LC3-II and PARP-1.Genetic Dissection of Cancer Development, Therapy Response, and Resistance in Mouse Models of Breast Cancer.Hereditary breast and ovarian cancer: new genes in confined pathways.Frequently mutated genes/pathways and genomic instability as prevention targets in liver cancer.Combining electron microscopy with single molecule DNA fiber approaches to study DNA replication dynamics.Moonlighting at replication forks - a new life for homologous recombination proteins BRCA1, BRCA2 and RAD51.Therapeutic targeting and patient selection for cancers with homologous recombination defects.The Role of Replication-Associated Repair Factors on R-LoopsProgression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells.BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination.Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments.CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes.PTIP promotes recurrence and metastasis of hepatocellular carcinoma by regulating epithelial-mesenchymal transition.Thwarting endogenous stress: BRCA protects against aldehyde toxicity.ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells.Replication fork reversal triggers fork degradation in BRCA2-defective cells.MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells.RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks.RADX interacts with single-stranded DNA to promote replication fork stability.53BP1 ablation rescues genomic instability in mice expressing 'RING-less' BRCA1The endonuclease EEPD1 mediates synthetic lethality in RAD52-depleted BRCA1 mutant breast cancer cells.Multi-BRCT Domain Protein Brc1 Links Rhp18/Rad18 and γH2A To Maintain Genome Stability during S Phase.The end-joining factor Ku acts in the end-resection of double strand break-free arrested replication forks.BRCA2 antagonizes classical and alternative nonhomologous end-joining to prevent gross genomic instability.53BP1 and BRCA1 control pathway choice for stalled replication restart.ZNF830 mediates cancer chemoresistance through promoting homologous-recombination repair.Frontiers in Medicinal Chemistry 2017 in Bern, Switzerland.The development of PARP as a successful target for cancer therapy.Replication Fork Reversal: Players and Guardians.PARPi focus the spotlight on replication fork protection in cancer.Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers.EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation.
P2860
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P2860
Replication fork stability confers chemoresistance in BRCA-deficient cells
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Replication fork stability confers chemoresistance in BRCA-deficient cells
@ast
Replication fork stability confers chemoresistance in BRCA-deficient cells
@en
type
label
Replication fork stability confers chemoresistance in BRCA-deficient cells
@ast
Replication fork stability confers chemoresistance in BRCA-deficient cells
@en
prefLabel
Replication fork stability confers chemoresistance in BRCA-deficient cells
@ast
Replication fork stability confers chemoresistance in BRCA-deficient cells
@en
P2093
P2860
P50
P356
P1433
P1476
Replication fork stability confers chemoresistance in BRCA-deficient cells
@en
P2093
Alexandra A Duarte
Amanda Day
André Nussenzweig
Anna Vidal Crespo
Arnab Ray Chaudhuri
Binghui Shen
David Cortez
Elsa Callen
Ewa Gogola
Jennifer A Calvo
P2860
P2888
P304
P356
10.1038/NATURE18325
P407
P577
2016-07-01T00:00:00Z