Protein homeostasis in models of aging and age-related conformational disease.
about
Histone deacetylase inhibitor (HDACi) suberoylanilide hydroxamic acid (SAHA)-mediated correction of α1-antitrypsin deficiencyLong live FOXO: unraveling the role of FOXO proteins in aging and longevityHeat shock proteins and hormesis in the diagnosis and treatment of neurodegenerative diseasesFOXO transcription factors: key regulators of cellular quality controlPrion Aggregates Are Recruited to the Insoluble Protein Deposit (IPOD) via Myosin 2-Based Vesicular TransportZinc Levels Modulate Lifespan through Multiple Longevity Pathways in Caenorhabditis elegansThe Wnt receptor Ryk reduces neuronal and cell survival capacity by repressing FOXO activity during the early phases of mutant huntingtin pathogenicityHDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegenerationNovel polyglutamine model uncouples proteotoxicity from agingThe struggle by Caenorhabditis elegans to maintain proteostasis during aging and diseaseProteomic data from human cell cultures refine mechanisms of chaperone-mediated protein homeostasisDistinct α-synuclein strains differentially promote tau inclusions in neuronsDynamic Sumoylation of a Conserved Transcription Corepressor Prevents Persistent Inclusion Formation during Hyperosmotic StressSuperior proteome stability in the longest lived animalMalfolded protein structure and proteostasis in lung diseases.Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress.Remodeling of Proteostasis Upon Transition to Adulthood is Linked to Reproduction Onset.Proteostasis and the aging proteome in health and disease.Myopathy-causing mutations in an HSP40 chaperone disrupt processing of specific client conformers.Photothermal confocal spectromicroscopy of multiple cellular chromophores and fluorophores.Mdm20 stimulates polyQ aggregation via inhibiting autophagy through Akt-Ser473 phosphorylation.Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome-blocking complexes.Relationship of electrophilic stress to agingWhat we can learn from animal models about cerebral multi-morbidity.Hypertonic stress induces rapid and widespread protein damage in C. elegans.Nuclear protein accumulation in cellular senescence and organismal aging revealed with a novel single-cell resolution fluorescence microscopy assayActive Degradation Explains the Distribution of Nuclear Proteins during Cellular Senescence.Quantitative proteomics of heat-treated human cells show an across-the-board mild depletion of housekeeping proteins to massively accumulate few HSPsMdm20 Modulates Actin Remodeling through the mTORC2 Pathway via Its Effect on Rictor ExpressionLongevity and GAPDH Stability in Bivalves and Mammals: A Convenient Marker for Comparative Gerontology and Proteostasis.Neurite sprouting and synapse deterioration in the aging Caenorhabditis elegans nervous systemA Differentiation Transcription Factor Establishes Muscle-Specific Proteostasis in Caenorhabditis elegans.Curcumin and neurodegenerative diseases.Targeting of exon VI-skipping human RGR-opsin to the plasma membrane of pigment epithelium and co-localization with terminal complement complex C5b-9Thinking laterally about neurodegenerative proteinopathies.Cytosolic proteins lose solubility as amyloid deposits in a transgenic mouse model of Alzheimer-type amyloidosis.Vulnerability of newly synthesized proteins to proteostasis stress.Principal component analysis of PiB distribution in Parkinson and Alzheimer diseases.The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease.Proteins that accumulate with age in human skeletal-muscle aggregates contribute to declines in muscle mass and function in Caenorhabditis elegans
P2860
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P2860
Protein homeostasis in models of aging and age-related conformational disease.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Protein homeostasis in models of aging and age-related conformational disease.
@ast
Protein homeostasis in models of aging and age-related conformational disease.
@en
type
label
Protein homeostasis in models of aging and age-related conformational disease.
@ast
Protein homeostasis in models of aging and age-related conformational disease.
@en
prefLabel
Protein homeostasis in models of aging and age-related conformational disease.
@ast
Protein homeostasis in models of aging and age-related conformational disease.
@en
P2093
P2860
P1476
Protein homeostasis in models of aging and age-related conformational disease.
@en
P2093
Elise A Kikis
Richard I Morimoto
Tali Gidalevitz
P2860
P304
P356
10.1007/978-1-4419-7002-2_11
P407
P577
2010-01-01T00:00:00Z