The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy
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Mitochondrial dysfunction in Parkinson's diseaseUbiquitin modificationsMyosins, Actin and AutophagyImpaired Autophagy and Defective Mitochondrial Function: Converging Paths on the Road to Motor Neuron DegenerationParkin Regulation and Neurodegenerative DisordersThe Function of Autophagy in Neurodegenerative DiseasesSending Out an SOS: Mitochondria as a Signaling HubTargeting Pink1-Parkin-mediated mitophagy for treating liver injuryThe TBK1-binding domain of optineurin promotes type I interferon responsesDynamic recruitment and activation of ALS-associated TBK1 with its target optineurin are required for efficient mitophagyLoss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell deathNeuronal Mitophagy in Neurodegenerative DiseasesThe PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activityProtein Quality Control and the Amyotrophic Lateral Sclerosis/Frontotemporal Dementia ContinuumStructure biology of selective autophagy receptors.The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing.The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradationMetabolism and the UPR(mt).Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria.Mechanisms of Selective Autophagy in Normal Physiology and CancerMAVS maintains mitochondrial homeostasis via autophagy.Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins.Miro phosphorylation sites regulate Parkin recruitment and mitochondrial motility.Tank-Binding Kinase 1 (TBK1) Gene and Open-Angle Glaucomas (An American Ophthalmological Society Thesis).Atg8 family LC3/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation.Structure of phosphorylated UBL domain and insights into PINK1-orchestrated parkin activation.PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson's Disease Pathobiology?Heterozygous PINK1 p.G411S increases risk of Parkinson's disease via a dominant-negative mechanism.Recent advances in quantitative and chemical proteomics for autophagy studies.Hydrophobic Patch of Ubiquitin is Important for its Optimal Activation by Ubiquitin Activating Enzyme E1.Phospho-ubiquitin: upending the PINK-Parkin-ubiquitin cascadeFluorescence-based ATG8 sensors monitor localization and function of LC3/GABARAP proteins.Mechanisms of Selective Autophagy.Molecular definitions of autophagy and related processes.Highly Multiplexed Quantitative Mass Spectrometry Analysis of Ubiquitylomes.Mechanisms of neuronal homeostasis: Autophagy in the axon.Stress granules at the intersection of autophagy and ALS.The increasing complexity of the ubiquitin code.The mitochondrial kinase PINK1: functions beyond mitophagy.Mechanistic insights into selective autophagy pathways: lessons from yeast.
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The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
The PINK1-PARKIN Mitochondrial ...... ctivation to Promote Mitophagy
@ast
The PINK1-PARKIN Mitochondrial ...... ctivation to Promote Mitophagy
@en
type
label
The PINK1-PARKIN Mitochondrial ...... ctivation to Promote Mitophagy
@ast
The PINK1-PARKIN Mitochondrial ...... ctivation to Promote Mitophagy
@en
prefLabel
The PINK1-PARKIN Mitochondrial ...... ctivation to Promote Mitophagy
@ast
The PINK1-PARKIN Mitochondrial ...... ctivation to Promote Mitophagy
@en
P2093
P2860
P1433
P1476
The PINK1-PARKIN Mitochondrial ...... ctivation to Promote Mitophagy
@en
P2093
Jesse Rinehart
Jin-Mi Heo
Joao A Paulo
P2860
P356
10.1016/J.MOLCEL.2015.08.016
P577
2015-09-10T00:00:00Z